Benjamin EJ, Blaha MJ, et al. Heart disease and stroke statistics—2017 update: a report from the American Heart Association. Circulation. 2017;135(10):e146–603.
Gulati M. Improving the cardiovascular health of women in the nation: moving beyond the bikini boundaries. Circulation. 2017;135(6):495–8.
Shaw LJ, Bairey Merz CN, et al. Insights from the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) study: part I: gender differences in traditional and novel risk factors, symptom evaluation, and gender-optimized diagnostic strategies. J Am Coll Cardiol. 2006a;47(3 Suppl):S4–S20.
Shaw LJ, Bugiardini R, et al. Women and ischemic heart disease: evolving knowledge. J Am Coll Cardiol. 2009;54(17):1561–75.
Bairey Merz CN, Andersen H, et al. Knowledge, attitudes, and beliefs regarding cardiovascular disease in women: the women’s heart alliance. J Am Coll Cardiol. 2017;70(2):123–32.
Institute of Medicine. Exploring the biological contributions to human health: does sex matter? Washington, DC: The National Academies Press; 2001.
Institute of Medicine Committee on Women’s Health Research. Women’s health research: progress, pitfalls, and promise. Washington, DC: National Academies Press (US) Copyright 2010 by the National Academy of Sciences; 2010. All rights reserved
Jackson EA, Nallamothu BK. Women are why. Circ Cardiovasc Qual Outcomes. 2017;10(2):pii: e003597.
Kim ES, Carrigan TP, et al. Enrollment of women in National Heart, Lung, and Blood Institute-funded cardiovascular randomized controlled trials fails to meet current federal mandates for inclusion. J Am Coll Cardiol. 2008;52(8):672–3.
Bucholz EM, Butala NM, et al. Sex differences in long-term mortality after myocardial infarction: a systematic review. Circulation. 2014;130(9):757–67.
Wenger NK. Women and coronary heart disease: a century after Herrick: understudied, underdiagnosed, and undertreated. Circulation. 2012;126(5):604–11.
Stillman AE, Gatsonis C, et al. Rationale and design of the Randomized Evaluation of patients with Stable angina Comparing Utilization of noninvasive Examinations (RESCUE) trial. Am Heart J. 2016;179:19–28.
Towfighi A, Zheng L, et al. Sex-specific trends in midlife coronary heart disease risk and prevalence. Arch Intern Med. 2009;169(19):1762–6.
Hess CN, Kaltenbach LA, et al. Race and sex differences in post-myocardial infarction angina frequency and risk of 1-year unplanned rehospitalization. Circulation. 2017;135(6):532–43.
Campisi R. Noninvasive assessment of coronary microvascular function in women at risk for ischaemic heart disease. Int J Clin Pract. 2008;62(2):300–7.
Mack M, Gopal A. Epidemiology, traditional and novel risk factors in coronary artery disease. Cardiol Clin. 2014;32(3):323–32.
Stampfer MJ, Colditz GA, et al. Postmenopausal estrogen therapy and cardiovascular disease: ten-year follow-up from the Nurses’ Health Study. N Engl J Med. 1991;325(11):756–62.
Lloyd-Jones D, Adams RJ, et al. Executive summary: heart disease and stroke statistics—2010 update: a report from the American Heart Association. Circulation. 2010;121(7):948.
Feinstein M, Ning H, et al. Racial differences in risks for first cardiovascular events and noncardiovascular death: the Atherosclerosis Risk in Communities study, the Cardiovascular Health Study, and the Multi-Ethnic Study of Atherosclerosis. Circulation. 2012;126(1):50–9.
Dreyer RP, Sciria C, et al. Young women with acute myocardial infarction: current perspectives. Circ Cardiovasc Qual Outcomes. 2017;10(2):pii: e003480.
Dreyer RP, Smolderen KG, et al. Gender differences in pre-event health status of young patients with acute myocardial infarction: a VIRGO study analysis. Eur Heart J Acute Cardiovasc Care. 2015;5(1):43–54.
Ford ES, Capewell S. Coronary heart disease mortality among young adults in the US from 1980 through 2002: concealed leveling of mortality rates. J Am Coll Cardiol. 2007;50(22):2128–32.
Hemingway H, Langenberg C, et al. Prevalence of angina in women versus men a systematic review and meta-analysis of international variations across 31 countries. Circulation. 2008;117(12):1526–36.
Zuchi C, Tritto I, et al. Angina pectoris in women: focus on microvascular disease. Int J Cardiol. 2013;163(2):132–40.
Eastwood J-A, Johnson BD, et al. Anginal symptoms, coronary artery disease, and adverse outcomes in black and white women: the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study. J Womens Health. 2013;22(9):724–32.
Mieres JH, Heller GV, et al. Signs and symptoms of suspected myocardial ischemia in women: results from the What Is the Optimal Method for Ischemia Evaluation in Women? Trial. J Womens Health. 2011;20(9):1261–8.
Gulati M, Cooper-DeHoff RM, et al. Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease: a report from the Women’s Ischemia Syndrome Evaluation Study and the St James Women Take Heart Project. Arch Intern Med. 2009;169(9):843–50.
Sharaf BL, Pepine CJ, et al. Detailed angiographic analysis of women with suspected ischemic chest pain (pilot phase data from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation [WISE] Study Angiographic Core Laboratory). Am J Cardiol. 2001;87(8):937–41.
Vaccarino V. Ischemic heart disease in women many questions, few facts. Circ Cardiovasc Qual Outcomes. 2010;3(2):111–5.
Shaw LJ, Merz CN, et al. The economic burden of angina in women with suspected ischemic heart disease: results from the National Institutes of Health—National Heart, Lung, and Blood Institute—sponsored Women’s Ischemia Syndrome Evaluation. Circulation. 2006b;114(9):894–904.
Shaw LJ, Shaw RE, et al. Impact of ethnicity and gender differences on angiographic coronary artery disease prevalence and in-hospital mortality in the American College of Cardiology–National Cardiovascular Data Registry. Circulation. 2008;117(14):1787–801.
Gulati M, Shaw LJ, et al. Myocardial ischemia in women: lessons from the NHLBI WISE study. Clin Cardiol. 2012;35(3):141–8.
Bransford TL, Ofili E. The paradox of coronary heart disease in African-American women. J Natl Med Assoc. 2000;92(7):327.
Mensah GA, Brown DW. An overview of cardiovascular disease burden in the United States. Health Aff. 2007;26(1):38–48.
Berger JS, Brown DL. Gender-age interaction in early mortality following primary angioplasty for acute myocardial infarction. Am J Cardiol. 2006;98(9):1140–3.
Gupta A, Wang Y, et al. Trends in acute myocardial infarction in young patients and differences by sex and race, 2001 to 2010. J Am Coll Cardiol. 2014;64(4):337–45.
Vaccarino V, Horwitz RI, et al. Sex differences in mortality after myocardial infarction: evidence for a sex-age interaction. Arch Intern Med. 1998;158(18):2054–62.
Vaccarino V, Parsons L, et al. Sex-based differences in early mortality after myocardial infarction. N Engl J Med. 1999;341(4):217–25.
van Loo HM, van den Heuvel ER, et al. Sex dependent risk factors for mortality after myocardial infarction: individual patient data meta-analysis. BMC Med. 2014;12(1):242.
Banks K, Lo M, et al. Angina in women without obstructive coronary artery disease. Curr Cardiol Rev. 2010;6(1):71.
Tamis-Holland JE, Lu J, et al. Sex differences in presentation and outcome among patients with type 2 diabetes and coronary artery disease treated with contemporary medical therapy with or without prompt revascularization: a report from the BARI 2D Trial (Bypass Angioplasty Revascularization Investigation 2 Diabetes). J Am Coll Cardiol. 2013;61(17):1767–76.
Handberg EM, Eastwood JA, et al. Clinical implications of the Women’s Ischemia Syndrome Evaluation: inter-relationships between symptoms, psychosocial factors and cardiovascular outcomes. Womens Health (Lond Engl). 2013;9(5):479–90.
Leung Yinko SS, Pelletier R, et al. Health-related quality of life in premature acute coronary syndrome: does patient sex or gender really matter? J Am Heart Assoc. 2014;3(4):pii: e000901.
Norris CM, Spertus JA, et al. Sex and gender discrepancies in health-related quality of life outcomes among patients with established coronary artery disease. Circ Cardiovasc Qual Outcomes. 2008;1(2):123–30.
Vaccarino V, Lin ZQ, et al. Gender differences in recovery after coronary artery bypass surgery. J Am Coll Cardiol. 2003;41(2):307–14.
Scheuner MT, Setodji CM, et al. Relation of familial patterns of coronary heart disease, stroke, and diabetes to subclinical atherosclerosis: the multi-ethnic study of atherosclerosis. Genet Med. 2008;10(12):879–87.
Kannel WB. Metabolic risk factors for coronary heart disease in women: perspective from the Framingham Study. Am Heart J. 1987;114(2):413–9.
Matthews KA, Crawford SL, et al. Are changes in cardiovascular disease risk factors in midlife women due to chronological aging or to the menopausal transition? J Am Coll Cardiol. 2009;54(25):2366–73.
Mokdad AH, Ford ES, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA. 2003;289(1):76–9.
Hokanson JE, Austin MA. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a metaanalysis of population-based prospective studies. J Cardiovasc Risk. 1996;3(2):213–9.
Lerner DJ, Kannel WB. Patterns of coronary heart disease morbidity and mortality in the sexes: a 26-year follow-up of the Framingham population. Am Heart J. 1986;111(2):383–90.
Reuterwall C, Hallqvist J, et al. Higher relative, but lower absolute risks of myocardial infarction in women than in men: analysis of some major risk factors in the SHEEP study. The SHEEP Study Group. J Intern Med. 1999;246(2):161–74.
Lew J, Sanghavi M, et al. Sex-based differences in cardiometabolic biomarkers. Circulation. 2017;135(6):544–55.
Berry JD, Dyer A, et al. Lifetime risks of cardiovascular disease. N Engl J Med. 2012;366(4):321–9.
Sharma K, Gulati M. Coronary artery disease in women: a 2013 update. Glob Heart. 2013;8(2):105–12.
Yang Q, Cogswell ME, et al. Trends in cardiovascular health metrics and associations with all-cause and CVD mortality among US adults. JAMA. 2012;307(12):1273–83.
Kling JM, Miller VM, et al. Go Red for Women cardiovascular health-screening evaluation: the dichotomy between awareness and perception of cardiovascular risk in the community. J Womens Health (Larchmt). 2013;22(3):210–8.
Mosca L, Hammond G, et al. Fifteen-year trends in awareness of heart disease in women results of a 2012 American Heart Association National Survey. Circulation. 2013;127(11):1254–63.
Kip KE, Marroquin OC, et al. Clinical importance of obesity versus the metabolic syndrome in cardiovascular risk in women: a report from the Women’s Ischemia Syndrome Evaluation (WISE) Study. Circulation. 2004;109(6):706–13.
Karim R, Stanczyk FZ, et al. Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women. Menopause. 2010;17(4):785–90.
Mosca L, Benjamin EJ, et al. Effectiveness-based guidelines for the prevention of cardiovascular disease in women—2011 update: a guideline from the american heart association. Circulation. 2011;57(12):1404–23.
Ridker PM, Rifai N, et al. Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women. JAMA. 2005;294(3):326–33.
Wong ND, Pio J, et al. Distribution of C-reactive protein and its relation to risk factors and coronary heart disease risk estimation in the National Health and Nutrition Examination Survey (NHANES) III. Prev Cardiol. 2001;4(3):109–14.
Salmon JE, Roman MJ. Subclinical atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus. Am J Med. 2008;121(10 Suppl 1):010.
Hall PS, Nah G, et al. Reproductive Factors and Incidence of Heart Failure Hospitalization in the Women’s Health Initiative. J Am Coll Cardiol. 2017;69:2517–26.
Mansoor H, Elgendy IY, et al. Duration of reproductive years and the risk of cardiovascular and cerebrovascular events in older women: insights from the National Health and Nutrition Examination Survey. J Womens Health (Larchmt). 2017;26(10):1047–52. https://doi.org/10.1089/jwh.2016.6013. [Epub ahead of print]
Lakshman R, Forouhi NG, et al. Early age at menarche associated with cardiovascular disease and mortality. J Clin Endocrinol Metab. 2009;94(12):4953–60.
Bairey Merz CN, Johnson BD, et al. Hypoestrogenemia of hypothalamic origin and coronary artery disease in premenopausal women: a report from the NHLBI-sponsored WISE study. J Am Coll Cardiol. 2003;41(3):413–9.
Tanz LJ, Stuart JJ, et al. Preterm delivery and maternal cardiovascular disease in young and middle-aged adult women. Circulation. 2017;135(6):578–89.
Ray JG, Vermeulen MJ, et al. Cardiovascular health after maternal placental syndromes (CHAMPS): population-based retrospective cohort study. Lancet. 2005;366(9499):1797–803.
Wu P, Haththotuwa R, et al. Preeclampsia and future cardiovascular health: a systematic review and meta-analysis. Circ Cardiovasc Qual Outcomes. 2017;10(2):e003497.
Han SH, Bae JH, et al. Sex differences in atheroma burden and endothelial function in patients with early coronary atherosclerosis. Eur Heart J. 2008;29(11):1359–69.
Reis SE, Holubkov R, et al. Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study. Am Heart J. 2001;141(5):735–41.
Bairey Merz CN, Pepine CJ. Syndrome X and microvascular coronary dysfunction. Circulation. 2011;124(13):1477–80.
Kothawade K, Bairey Merz CN. Microvascular coronary dysfunction in women: pathophysiology, diagnosis, and management. Curr Probl Cardiol. 2011;36(8):291–318.
von Mering GO, Arant CB, et al. Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: results from the National Heart, Lung, and Blood Institute-Sponsored Women’s Ischemia Syndrome Evaluation (WISE). Circulation. 2004;109(6):722–5.
Suwaidi JA, Hamasaki S, et al. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation. 2000;101(9):948–54.
Kones R. Primary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey. Drug Des Devel Ther. 2011;5:325–80.
Madhok V, Fahey T. Cardiovascular risk estimation: important but may be inaccurate. BMJ. 2006;332(7555):1422.
Conroy RM, Pyorala K, et al. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J. 2003;24(11):987–1003.
Hippisley-Cox J, Coupland C, et al. Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort study. BMJ. 2007;335(7611):136.
NCEP. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation. 2002;106(25):3143.
Ridker PM, Buring JE, et al. Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score. JAMA. 2007;297(6):611–9.
Wenger NK. The Reynolds Risk Score: improved accuracy for cardiovascular risk prediction in women? Nat Clin Pract Cardiovasc Med. 2007;4(7):366–7.
Goff DC, Lloyd-Jones DM, et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. Circulation. 2014;129(25 suppl 2):S49–73.
Gulati M, Noel Bairey Merz C. New cholesterol guidelines and primary prevention in women. Trends Cardiovasc Med. 2014;25(2):84–94.
Cook NR, Ridker PM. Further insight into the cardiovascular risk calculator: the roles of statins, revascularizations, and underascertainment in the Women’s Health Study. JAMA Intern Med. 2014;174(12):1964–71.
Ridker PM, Cook NR. Statins: new American guidelines for prevention of cardiovascular disease. Lancet. 2013;382(9907):1762–5.
Canto JG, Rogers WJ, et al. Association of age and sex with myocardial infarction symptom presentation and in-hospital mortality. JAMA. 2012;307(8):813–22.
Johnson BD, Shaw LJ, et al. Persistent chest pain predicts cardiovascular events in women without obstructive coronary artery disease: results from the NIH-NHLBI-sponsored Women’s Ischaemia Syndrome Evaluation (WISE) study. Eur Heart J. 2006;27(12):1408–15.
Reynolds HR, Srichai MB, et al. Mechanisms of myocardial infarction in women without angiographically obstructive coronary artery disease. Circulation. 2011;124(13):1414–25.
Abdelmoneim SS, Bernier M, et al. Assessment of myocardial perfusion during adenosine stress using real time three-dimensional and two-dimensional myocardial contrast echocardiography: comparison with single-photon emission computed tomography. Echocardiography. 2010;27(4):421–9.
Tweet MS, Hayes SN, et al. Clinical features, management, and prognosis of spontaneous coronary artery dissection. Circulation. 2012;126(5):579–88.
Yip A, Saw J. Spontaneous coronary artery dissection—a review. Cardiovasc Diagn Ther. 2015;5(1):37–48.
Mieres JH, Gulati M, et al. Role of noninvasive testing in the clinical evaluation of women with suspected ischemic heart disease: a consensus statement from the American Heart Association. Circulation. 2014;130(4):350–79.
Diamond GA, Forrester JS. Analysis of probability as an aid in the clinical-diagnosis of coronary-artery disease. N Engl J Med. 1979;300(24):1350–8.
Gulati M, Pandey DK, et al. Exercise capacity and the risk of death in women: the St James Women Take Heart Project. Circulation. 2003;108(13):1554–9.
Bourque JM, Holland BH, et al. Achieving an exercise workload of ≥10 metabolic equivalents predicts a very low risk of inducible ischemia: does myocardial perfusion imaging have a role? J Am Coll Cardiol. 2009;54(6):538–45.
Kohli P, Gulati M. Exercise stress testing in women: going back to the basics. Circulation. 2010;122(24):2570–80.
Hlatky MA, Pryor DB, et al. Factors affecting sensitivity and specificity of exercise electrocardiography. Multivariable analysis. Am J Med. 1984;77(1):64–71.
Alexander KP, Shaw LJ, et al. Value of exercise treadmill testing in women. J Am Coll Cardiol. 1998;32(6):1657–64.
Kim C, Kwok YS, et al. Pharmacologic stress testing for coronary disease diagnosis: a meta-analysis. Am Heart J. 2001;142(6):934–44.
Marwick TH, Nemec JJ, et al. Accuracy and limitations of exercise echocardiography in a routine clinical setting. J Am Coll Cardiol. 1992;19(1):74–81.
Williams MJ, Marwick TH, et al. Comparison of exercise echocardiography with an exercise score to diagnose coronary artery disease in women. Am J Cardiol. 1994;74(5):435–8.
Roger VL, Pellikka PA, et al. Sex and test verification bias. Impact on the diagnostic value of exercise echocardiography. Circulation. 1997;95(2):405–10.
Arruda-Olson AM, Juracan EM, et al. Prognostic value of exercise echocardiography in 5,798 patients: is there a gender difference? J Am Coll Cardiol. 2002;39(4):625–31.
McCully RB, Roger VL, et al. Outcome after normal exercise echocardiography and predictors of subsequent cardiac events: follow-up of 1,325 patients. J Am Coll Cardiol. 1998;31(1):144–9.
Gerber TC, Gibbons RJ. Weighing the risks and benefits of cardiac imaging with ionizing radiation. JACC Cardiovasc Imaging. 2010;3(5):528–35.
Min JK, Dunning A, et al. Age- and sex-related differences in all-cause mortality risk based on coronary computed tomography angiography findings results from the International Multicenter CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry) of 23,854 patients without known coronary artery disease. J Am Coll Cardiol. 2011;58(8):849–60.
Hoffmann U, Bamberg F, et al. Coronary computed tomography angiography for early triage of patients with acute chest pain: the ROMICAT (Rule Out Myocardial Infarction using Computer Assisted Tomography) trial. J Am Coll Cardiol. 2009;53(18):1642–50.
Schlett CL, Banerji D, et al. Prognostic value of CT angiography for major adverse cardiac events in patients with acute chest pain from the emergency department: 2-year outcomes of the ROMICAT trial. JACC Cardiovasc Imaging. 2011;4(5):481–91.
Devries S, Wolfkiel C, et al. Influence of age and gender on the presence of coronary calcium detected by ultrafast computed tomography. J Am Coll Cardiol. 1995;25(1):76–82.
Budoff MJ, Shokooh S, et al. Electron beam tomography and angiography: sex differences. Am Heart J. 2002;143(5):877–82.
Douglas PS, Hoffmann U, et al. Outcomes of anatomical versus functional testing for coronary artery disease. N Engl J Med. 2015;372(14):1291–300.
ClinicalTrials.gov. International study of comparative health effectiveness with medical and invasive approaches (ISCHEMIA).
Herrmann J, Kaski JC, et al. Coronary microvascular dysfunction in the clinical setting: from mystery to reality. Eur Heart J. 2012;33(22):2771–82b.
Wei J, Mehta PK, et al. Safety of coronary reactivity testing in women with no obstructive coronary artery disease. JACC Cardiovasc Interv. 2012;5(6):646–53.
Pepine CJ, Anderson RD, et al. Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia results from the National Heart, Lung and Blood Institute WISE (Women’s Ischemia Syndrome Evaluation) study. J Am Coll Cardiol. 2010;55(25):2825–32.
Rossi R, Nuzzo A, et al. Prognostic role of flow-mediated dilation and cardiac risk factors in post-menopausal women. J Am Coll Cardiol. 2008;51(10):997–1002.
Bonetti PO, Pumper GM, et al. Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia. J Am Coll Cardiol. 2004;44(11):2137–41.
Matsuzawa Y, Sugiyama S, et al. Digital assessment of endothelial function and ischemic heart disease in women. J Am Coll Cardiol. 2010;55(16):1688–96.
Lerman A, Sopko G. Women and cardiovascular heart disease: clinical implications from the Women’s Ischemia Syndrome Evaluation (WISE) Study. Are we smarter? J Am Coll Cardiol. 2006;47(3 Suppl):S59–62.
Hasdai D, Cannan CR, et al. Evaluation of patients with minimally obstructive coronary artery disease and angina. Int J Cardiol. 1996;53(3):203–8.
Taqueti VR, Shaw LJ, et al. Excess cardiovascular risk in women relative to men referred for coronary angiography is associated with severely impaired coronary flow reserve, not obstructive disease. Circulation. 2017;135(6):566–77.
Amsterdam EA, Wenger NK, et al. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;64(24):e139–228.
Blomkalns AL, Chen AY, et al. Gender disparities in the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes: large-scale observations from the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the American College of Cardiology/American Heart Association Guidelines) National Quality Improvement Initiative. J Am Coll Cardiol. 2005;45(6):832–7.
Daly C, Clemens F, et al. Gender differences in the management and clinical outcome of stable angina. Circulation. 2006;113(4):490–8.
Dey S, Flather MD, et al. Sex-related differences in the presentation, treatment and outcomes among patients with acute coronary syndromes: the Global Registry of Acute Coronary Events. Heart. 2009;95(1):20–6.
Gehrie ER, Reynolds HR, et al. Characterization and outcomes of women and men with non-ST-segment elevation myocardial infarction and nonobstructive coronary artery disease: results from the can rapid risk stratification of unstable angina patients suppress adverse outcomes with early implementation of the ACC/AHA guidelines (CRUSADE) quality improvement initiative. Am Heart J. 2009;158(4):688–94.
Steg PG, Greenlaw N, et al. Women and men with stable coronary artery disease have similar clinical outcomes: insights from the international prospective CLARIFY registry. Eur Heart J. 2012;33(22):2831–40.
Antiplatelet Trialists’ Collaboration. Collaborative overview of randomised trials of antiplatelet therapy—I: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists’ Collaboration. BMJ. 1994;308(6921):81–106.
Chan AT, Manson JE, et al. Long-term aspirin use and mortality in women. Arch Intern Med. 2007;167(6):562–72.
O’Donoghue M, Boden WE, et al. Early invasive vs conservative treatment strategies in women and men with unstable angina and non-ST-segment elevation myocardial infarction: a meta-analysis. JAMA. 2008;300(1):71–80.
Gupta A, Chui P, et al. Frequency and effects of excess dosing of anticoagulants in patients </=55 years with acute myocardial infarction who underwent percutaneous coronary intervention (from the VIRGO Study). Am J Cardiol. 2015;116(1):1–7.
Balady GJ, Ades PA, et al. Referral, enrollment, and delivery of cardiac rehabilitation/secondary prevention programs at clinical centers and beyond a presidential advisory from the American Heart Association. Circulation. 2011;124(25):2951–60.
Lavie CJ, Milani RV. Effects of cardiac rehabilitation and exercise training on exercise capacity, coronary risk factors, behavioral characteristics, and quality of life in women. Am J Cardiol. 1995;75(5):340–3.
Lerman A, Burnett JC Jr, et al. Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans. Circulation. 1998;97(21):2123–8.
Crea F, Camici PG, et al. Coronary microvascular dysfunction: an update. Eur Heart J. 2014;35(17):1101–11.
Anderson GL, Limacher M, et al. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women’s Health Initiative randomized controlled trial. JAMA. 2004;291(14):1701–12.
Rossouw JE, Anderson GL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA. 2002;288(3):321–33.
Grady D, Herrington D, et al. Cardiovascular disease outcomes during 6.8 years of hormone therapy: heart and estrogen/progestin replacement study follow-up (HERS II). JAMA. 2002;288(1):49–57.
Hulley S, Grady D, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA. 1998;280(7):605–13.
Harman SM, Black DM, et al. Arterial imaging outcomes and cardiovascular risk factors in recently menopausal women: a randomized trial. Ann Intern Med. 2014;161(4):249–60.
Hodis HN, Mack WJ, et al. Vascular effects of early versus late postmenopausal treatment with estradiol. N Engl J Med. 2016;374(13):1221–31.