Abstract
We introduce a general method for compiling any combinatorial circuit into an input/output chemical reaction network (I/O CRN). An I/O CRN receives a robust input signal over time, processes it catalytically to produce an output signal, and operates under deterministic mass action semantics (mass action kinetics). Our construction is reusable in the sense that it continues to operate correctly under changing input signals, and we prove that the construction is robust with respect to perturbations in (1) input signals; (2) initial concentrations; (3) rate constants; and (4) output measurements.
This work is supported by National Science Foundation grants 1247051 and 1545028.
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Acknowledgments
We thank Jack Lutz and the Laboratory of Molecular Programming at Iowa State University for useful discussions.
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Ellis, S.J., Klinge, T.H., Lathrop, J.I. (2017). Robust Combinatorial Circuits in Chemical Reaction Networks. In: MartÃn-Vide, C., Neruda, R., Vega-RodrÃguez, M. (eds) Theory and Practice of Natural Computing. TPNC 2017. Lecture Notes in Computer Science(), vol 10687. Springer, Cham. https://doi.org/10.1007/978-3-319-71069-3_14
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