Chemotherapy in Neonates and Infants with Cancer and Other Congenital Diseases: Down Syndrome and HIV
Although patients with Down syndrome (patients who carrier trisomy 21 mosaics) may have a disposition to develop some malignancies, such as acute leukemias—with a 10- to 20-fold increased risk of developing this kind of disease—they have a markedly decreased incidence of solid tumors. These patients also have a particular profile of treatment-related toxicities [72, 73].
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