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Schizophrenia

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5-HT2A Receptors in the Central Nervous System

Part of the book series: The Receptors ((REC,volume 32))

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Abstract

The observations that hallucinogenic drugs are in fact serotonin 5-HT2A receptor agonists and atypical antipsychotic drugs antagonize 5-HT2A receptors in addition to dopamine D2-like receptors, led to envisage a close relationship between schizophrenia and serotonin transmission. Post mortem studies have shown diminished 5-HT2A receptor binding in brain tissue from people with schizophrenia. If these changes also occur in schizophrenia, the decreased 5-HT2A binding might be a compensatory effect resulting from increased cortical serotonergic transmission. Therefore, schizophrenic personality was associated to an excess of brain serotonin. Overall, such data suggests that 5-HT systems may play a role in the etiology and therapy of some aspects of schizophrenia. Nevertheless, there is no simple hypothesis of schizophrenia involving a single transmitter dysfunction in the brain. Thus, although initial views suggest increased serotonergic and dopaminergic transmission over 5-HT2A and D2 receptors in schizophrenia, current hypotheses for both etiology and treatment of the disease also implicate 5-HT1A and D2 receptor partial agonism in the development of novel antipsychotics with a better therapeutic profile and fewer adverse effects. In this chapter we review the role that serotonin and 5-HT2A receptors play in schizophrenia as well as the most relevant schizophrenia-related behavioral effects induced by hallucinogen drugs in rodents, focusing on those that involve a 5-HT2A receptor mechanism.

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Authors and Affiliations

  1. CSIC-Institut d’Investigacions Biomèdiques de Barcelona-CIBERSAM-IDIBAPS, Barcelona, Spain

    Anna Castañé

  2. Institute of Biomedicine and Biotechnology of Cantabria, IBBTEC (CSIC-University of Cantabria), Santander, Spain

    Albert Adell

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  1. Anna Castañé
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  2. Albert Adell
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Correspondence to Anna Castañé .

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Editors and Affiliations

  1. Faculté de Pharmacie, Université Paris Sud, Université Paris-Saclay, Chatenay-Malabry, France

    Bruno P. Guiard

  2. Department of Physiology and Biochemistry, University of Malta, Msida MSD, Malta

    Giuseppe Di Giovanni

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Castañé, A., Adell, A. (2018). Schizophrenia. In: Guiard, B., Di Giovanni, G. (eds) 5-HT2A Receptors in the Central Nervous System. The Receptors, vol 32. Humana Press, Cham. https://doi.org/10.1007/978-3-319-70474-6_8

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