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Serotonergic Receptor 5-HT2A in the Cardiosympathovagal System

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Book cover 5-HT2A Receptors in the Central Nervous System

Part of the book series: The Receptors ((REC,volume 32))

Abstract

The serotonin receptor 5-HT2A is widely expressed throughout the central nervous system. While abundant evidence exits implicating 5-HT2A receptors in regulating central nervous system, in particular stress responses and that their expression levels or signaling can contribute to stress-related disorders such as anxiety, depression and aggression; the 5-HT2A receptors is also gaining importance in regulating the activity of the autonomic nervous system. Elucidating the functional specificity and significance of the 5HT2A receptor in autonomic function is a challenge given the existence and often co-localization of other 5HT2 receptor subtypes, the central and peripheral expression pattern of the 5HT2A receptor, and the relative poor selectivity of the pharmacological agents used to identify their function. Data has long been accumulated indicating that the 5-HT2A receptor-induced regulation of the autonomic nervous system function appears to be mediated, at least in part, through the regulation of the serotoninergic afferents and efferents to the nucleus tractus solitarius. In this article, we review the role of 5-HT2A receptor function in the modulation of cardiac sympathovagal balance with special emphasis on the networks by which 5-HT2A receptors modulate the function of the nucleus tractus solitarius in regulating the baroreflex and autonomic function.

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Author information

Authors and Affiliations

  1. Institut des Maladies Métaboliques et Cardiovasculaires, INSERM UMR1048, Université Paul Sabatier, Toulouse, France

    M. Kermorgant, A. Pavy-Le Traon, J. M. Senard & D. N. Arvanitis

  2. Department of Neurology, Institute for Neurosciences, University Hospital of Toulouse, Toulouse, France

    A. Pavy-Le Traon

  3. Department of Clinical Pharmacology, University Hospital of Toulouse, Toulouse, France

    J. M. Senard

Authors
  1. M. Kermorgant
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  2. A. Pavy-Le Traon
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  3. J. M. Senard
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  4. D. N. Arvanitis
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Corresponding author

Correspondence to D. N. Arvanitis .

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Editors and Affiliations

  1. Faculté de Pharmacie, Université Paris Sud, Université Paris-Saclay, Chatenay-Malabry, France

    Bruno P. Guiard

  2. Department of Physiology and Biochemistry, University of Malta, Msida MSD, Malta

    Giuseppe Di Giovanni

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Kermorgant, M., Pavy-Le Traon, A., Senard, J.M., Arvanitis, D.N. (2018). Serotonergic Receptor 5-HT2A in the Cardiosympathovagal System. In: Guiard, B., Di Giovanni, G. (eds) 5-HT2A Receptors in the Central Nervous System. The Receptors, vol 32. Humana Press, Cham. https://doi.org/10.1007/978-3-319-70474-6_6

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