Brain Distribution

Part of the The Receptors book series (REC, volume 32)


The 5-HT2A receptor type (5-HT2AR) is a G-protein-coupled receptor widely distributed in the central nervous system, indicating its participation in numerous neurological effects serotonin-mediated. The 5-HT2AR has attracted interest as a potential drug target for the treatment of several important neurologic and psychiatric disorders, such as epilepsy and depression. The distribution of the 5-HT2AR has been investigated by immunohistochemical stainings, in situ hybridization experiments, and physiologic/pharmacologic procedures. This review summarizes the cellular localization of the 5-HT2AR in the brains, providing the neuronal pathways modulated by serotonin through this specific receptor type.


5-HT2A receptor Serotonin Thelencephalon Diencephalon Brainstem 


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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Veterinary Medical SciencesUniversity of BolognaOzzano dell’EmiliaItaly

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