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5-HT2A Receptors and Pain

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5-HT2A Receptors in the Central Nervous System

Part of the book series: The Receptors ((REC,volume 32))

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is a key modulator of spinal nociceptive transmission. Among 5-HT receptors, the 5-HT2A subtype plays a critical role in the modulation of nociceptive information. Both pro- and antinociceptive effects of 5-HT2A receptor activation have been reported but converging evidence indicates an excitatory role for peripheral 5-HT2A receptors on pain transmission in acute, sub-chronic and chronic pain conditions. The central effects of 5-HT2A agonists which produce either anti-hyperalgesic or anti-allodynic effect seem to depend on the pathophysiology of pain. Neverthless, some data indicate that 5-HT acting drugs such as selective serotonin reuptake inhibitor (SSRI) antidepressants involve the 5-HT2A receptor to produce analgesia and that restoring 5-HT2A receptor functionality may contribute to enhance the analgesic efficacy of SSRI in metabolic and traumatic neuropathic pain.

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Authors and Affiliations

  1. INSERM U1107, NEURO-DOL, Clermont-Ferrand, France

    Christine Courteix, Amandine Dupuis, Pierre-Yves Martin & Benoit Sion

  2. Laboratoire de Physiologie, UFR Pharmacie, Université Clermont Auvergne, Clermont-Ferrand, France

    Christine Courteix, Amandine Dupuis, Pierre-Yves Martin & Benoit Sion

Authors
  1. Christine Courteix
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  2. Amandine Dupuis
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  3. Pierre-Yves Martin
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  4. Benoit Sion
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Correspondence to Christine Courteix .

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Editors and Affiliations

  1. Faculté de Pharmacie, Université Paris Sud, Université Paris-Saclay, Chatenay-Malabry, France

    Bruno P. Guiard

  2. Department of Physiology and Biochemistry, University of Malta, Msida MSD, Malta

    Giuseppe Di Giovanni

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Courteix, C., Dupuis, A., Martin, PY., Sion, B. (2018). 5-HT2A Receptors and Pain. In: Guiard, B., Di Giovanni, G. (eds) 5-HT2A Receptors in the Central Nervous System. The Receptors, vol 32. Humana Press, Cham. https://doi.org/10.1007/978-3-319-70474-6_14

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