5-HT2A/2B/2C Receptors, Memory and Therapeutic Targets

  • Alfredo Meneses
  • Rossana Nieto-Vera
  • Rosa María Anaya-Jiménez
Chapter
Part of the The Receptors book series (REC, volume 32)

Abstract

The 5-HT2 receptors subdivision into the 5-HT2A/2B/2C subtypes along with the advent of the selective antagonists has allowed a more detailed investigation on the role and therapeutic significance of these subtypes in cognitive functions. It is suggested that, 5-HT2B/2C receptors might be involved on memory formation probably mediating a suppressive or constraining action. Whether the drug-induced learning impairments in this study are explained by simple agonism, antagonism or inverse agonism at 5-HT2 receptors remains unclear at this time. Notably, the 5-HT2 receptor subtypes blockade may provide some benefit to reverse poor memory consolidation conditions associated with decreased cholinergic, glutamatergic, and/or serotonergic neurotransmission.

Keywords

Autoshaping 5-HT2A/2B/2C Receptors Memory consolidation Serotonin Rats 

Notes

Acknowledgments

The author also wants to thank Sofia Meneses for the language review and the technical assistance of Roberto Gonzalez.

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Alfredo Meneses
    • 1
  • Rossana Nieto-Vera
    • 2
  • Rosa María Anaya-Jiménez
    • 2
  1. 1.Department of Pharmacobiology, CINVESTAVMéxico CityMexico
  2. 2.Facultad de Ciencias de la SaludUniversidad Anáhuac México NorteMéxico CityMexico

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