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Chemical Peels in Pigmentary Disorders

  • Rashmi Sarkar
  • Shivani Bansal
Chapter
Part of the Updates in Clinical Dermatology book series (UCD)

Abstract

Chemical peels are methods to cause a chemical ablation ofdefined skin layers to induce an even and tight skin as a result ofthe regeneration process. The list of agents for chemical peeling isextensive. The usual classification of chemical peels comprises superficial, medium and deep peels. For superficial peels alpha hydroxy acids and most recently lipo-hydroxy acid act by inducing an exfoliation of the epidermis. Medium-depth agents such as trichloroacetic acid (<50%) cause an epidermal to papillary dermal peel and regeneration. Deep peels using trichloroacetic acid (>50%) or phenol-based formulations reach the reticular dermis to induce dermal regeneration. Although a number of new agents have come up, there is little published evidence supporting their use in day-to-day practice.

Keywords

Melasma Chemical peel Glycolic acid Phytic acid Tretinoin peel TCA peel Jessner’s solution Priming agent 

References

  1. 1.
    Grimes PE. Melasma. Etiologic and therapeutic considerations. Arch Dermatol. 1995;131(12):1453–7.CrossRefGoogle Scholar
  2. 2.
    Brody HJ, Monheit GD, Resnick SS, et al. A history of chemical peeling. Dermatol Surg. 2000;26:405–9.CrossRefGoogle Scholar
  3. 3.
    Mackee GM, Karp FL. The treatment of post acne scars with phenol. Br J Dermatol. 1952;64:456–9.CrossRefGoogle Scholar
  4. 4.
    Stegman SJ. A comparative histologic study of the effects of three peeling agents and dermabrasion on normal and sun damaged skin. Aesthet Plast Surg. 1982;6:123–35.CrossRefGoogle Scholar
  5. 5.
    Glogou RG. Chemical peeling and aging skin. J Geriatr Dermatol. 1994;2:30–5.Google Scholar
  6. 6.
    Roberts WE. Chemical peeling in ethnic/dark skin. Dermatol Ther. 2004;17:196–205.CrossRefGoogle Scholar
  7. 7.
    Rubin ME. Superficial and medium depth, Manual of chemical peels. Philadelphia: Lippincott; 1995. p. 17–25.Google Scholar
  8. 8.
    Lim JT, Tham SN. Glycolic acid peels in the treatment of melasma among Asian women. Dermatol Surg. 1997;23:177–9.CrossRefGoogle Scholar
  9. 9.
    Javaheri SM, Handa S, Kaur I, Kumar B. Safety and efficacy of glycolic acid facial peel in Indian women with melasma. Int J Dermatol. 2001;40:354.CrossRefGoogle Scholar
  10. 10.
    Grover C, Reddu BS. The therapeutic value of glycolic acid peels in dermatology. Indian J Dermatol Venereol Leprol. 2003;69:148–50.PubMedGoogle Scholar
  11. 11.
    Godse KV, Sakhia J. Triple combination and glycolic acid peels in melasma in Indian patients. J Cosmet Dermatol. 2011;10:68–9.CrossRefGoogle Scholar
  12. 12.
    Sharquie KE, Al-Tikreety MM, Al-Mashhadani SA. Lactic acid as a new therapeutic peeling agent in melasma. Dermatol Surg. 2005;31:149–54.CrossRefGoogle Scholar
  13. 13.
    Griffin TD, Van Scott EJ, Maddin S. The use of pyruvic acid as a chemical peeling agent. J Dermatol Surg Oncol. 1989;15:13.Google Scholar
  14. 14.
    Ahn HH, Kim IH. Whitening effect of salicylic acid peels in Asian patients. Dermatol Surg. 2006;32:372–5.PubMedGoogle Scholar
  15. 15.
    Grimes PE. The safety and efficacy of salicylic acid chemical peels in darker racial-ethnic groups. Dermatol Surg. 1999;25(1):18–22.CrossRefGoogle Scholar
  16. 16.
    Sarkar R, Garg V, Bansal S, Sethi S, Gupta C. Comparative evaluation of efficacy and tolerability of glycolic acid, salicylic mandelic acid, and phytic acid combination peels in melasma. Dermatol Surg. 2016;42(3):384–91.CrossRefGoogle Scholar
  17. 17.
    Zakopoulou N, Kontochristopoulos G. Superficial chemical peels. J Cosmet Dermatol. 2006;5:246–53.CrossRefGoogle Scholar
  18. 18.
    Kumari R, Thappa DM. Comparative study of trichloroacetic acid versus glycolic acid chemical peels in the treatment of melasma. Indian J Dermatol Venereol Leprol. 2010;76:447.PubMedGoogle Scholar
  19. 19.
    Lawrence N, Cox SE, Brody HJ. Treatment of melasma withJessner’s solution versus glycolic acid: a comparison ofclinical efficacy and evaluation of the predictive ability ofWood’s light examination. J Am Acad Dermatol. 1997;36:589–93.CrossRefGoogle Scholar
  20. 20.
    Monheit GD. The Jessner’s trichloroacetic acid peel. Anenhanced medium-depth chemical peel. Dermatol Clin. 1995;13:277–83.CrossRefGoogle Scholar
  21. 21.
    Cuce LC, Bertino MC, Scattone L, Birkenhauer MC. Tretinoin peeling. Dermatol Surg. 2001;25:12–4.Google Scholar
  22. 22.
    Khunger N, Sarkar R, Jain RK. Tretinoin peels versus glycolic acid peels in the treatment of Melasma in dark-skinned patients. Dermatol Surg. 2004;30:756–60.PubMedGoogle Scholar
  23. 23.
    Deprez P. Easy phytic solution: a new alpha hydroxy acid peel with slow release and without neutralization. Int J Cosmet Surg Aesth Dermatol. 2003;5:45–51.CrossRefGoogle Scholar
  24. 24.
    Obagi ZE, Obagi S, Alaiti S, Stevens MB. TCA-based blue peel: a standardized procedure with depth control. Dermatol Surg. 1999;25:773–80.CrossRefGoogle Scholar
  25. 25.
    Hong SP, Han SS, Choi SJ, Kim MS, Won CH, Lee MW, et al. Split-face comparative study of 1550 nm fractional photothermolysis and trichloroacetic acid 15% chemical peeling for facial melasma in Asian skin. J Cosmet Laser Ther. 2012;14:81–6.CrossRefGoogle Scholar
  26. 26.
    Klein M. Amino fruit acids: the new cosmeceutical. Cosmet Dermatol. 2000;13:25–8.Google Scholar
  27. 27.
    Ilknur T, Bicak MU, Demirtaroglu M, Ozkan S. Glycolic acid peels versus amino fruit acid peels in the treatment of melasma. Dermatol Surg. 2010;36:490–5.CrossRefGoogle Scholar
  28. 28.
    Faghihi G, Taheri A, Shahmoradi Z, Nilforoushzadeh MA. Solution of azelaic acid (20%), resorcinol (10%) and phytic acid (6%) versus glycolic acid (50%) peeling agent in the treatment of female patients with facial melasma. Adv Biomed Res. 2017;6:9.CrossRefGoogle Scholar
  29. 29.
    Garg VK, Sarkar R, Agarwal R. Comparative evaluation of beneficiary effects of priming agents (2% hydroquinone and 0.025% retinoic acid) in the treatment of melasma with glycolic acid peels. Dermatol Surg. 2008;34:1032–40.PubMedGoogle Scholar
  30. 30.
    Nanda S, Grover C, Reddy BS. Efficacy of hydroquinone (2%) versus tretinoin (0.025%) as adjunct topical agents for chemical peeling in patients of melasma. Dermatol Surg. 2004;30:385–8.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Rashmi Sarkar
    • 1
  • Shivani Bansal
    • 2
  1. 1.Department of DermatologyMaulana Azad Medical CollegeNew DelhiIndia
  2. 2.Kaya Skin ClinicPreet ViharIndia

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