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Nanoformulations for Cancer Therapy

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Nanotechnology Applied To Pharmaceutical Technology

Abstract

Recent progress in the field of science and technology has catered us with new dimensions to understand the origin and complexity of biological events associated with the development of cancer. Growth of cancer is a multi-stage process which involves diverse genetic alterations and cellular signalling pathways, responsible for the development and maturation of tumours. Based on the recent advancement, several new strategies in cancer therapy are now available that offers better therapeutic results. However, there are a number of issues still existing which need to be addressed intensely to obtain effective results in cancer therapy thereby decreasing the mortality rate. Moreover, generation of resistant cancer cells after treatment with conventional methods is liable to depict an adverse scenario in cancer therapy, which demands new therapeutic and diagnostic modules in order to combat this fatal disease.

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Abbreviations

Ag NPs:

Silver nanoparticles

Au NPs:

Gold nanoparticles

Cl− :

Chloride ions

Cu NPs:

Copper nanoparticles

CuO:

Copper oxide

DOX:

Doxorubicin

ECM:

Extracellular matrix

EPR:

Enhanced permeation and retention

HCPT:

10-Hydroxycamptothecine

LDH:

Lactate dehydrogenase

MEC:

Minimum effective concentration

MTs:

Metallothioneins

NGS:

Next-generation sequencing

NH2 :

Amine group

NIR:

Near-infrared light

NP:

Nanoparticles

PD:

Paracetamol dimer

PDT:

Photodynamic therapy

PEG:

Polyethylene glycol (PEG)

PS:

Photosensitizers

PSMA:

Prostate-specific membrane antigen

PTN:

Photothermalnanotherapeutics

PTT:

Photothermal therapy

PTX:

Paclitaxel

PVP:

Polyvinylpyrrolidone

QDs:

Quantum dots

RES:

Reticuloendothelial system

RNA:

Ribonucleic acid

ROS:

Reactive oxygen species

SERS:

Surface-enhanced Raman scattering

SPR:

Surface plasmon resonance

TiO2 :

Titanium oxide

WHO:

World Health Organization

ZnO:

Zinc oxide

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Authors and Affiliations

  1. Department of Applied Sciences, Indian Institute of Information Technology, Allahabad, 211012, Uttar Pradesh, India

    Amaresh Kumar Sahoo, Arushi Verma & Prerna Pant

Authors
  1. Amaresh Kumar Sahoo
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  2. Arushi Verma
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  3. Prerna Pant
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Corresponding author

Correspondence to Amaresh Kumar Sahoo .

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Editors and Affiliations

  1. Department of Biotechnology, SGB Amravati University, Amravati, Maharashtra, India

    Mahendra Rai

  2. School of Pharmaceutical Sciences, University of Sorocaba, Sorocaba, São Paulo, Brazil

    Carolina Alves dos Santos

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Sahoo, A.K., Verma, A., Pant, P. (2017). Nanoformulations for Cancer Therapy. In: Rai, M., Alves dos Santos, C. (eds) Nanotechnology Applied To Pharmaceutical Technology. Springer, Cham. https://doi.org/10.1007/978-3-319-70299-5_7

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