Abstract
Acute infections of the nervous system are among the most important problems in medicine because early recognition, efficient decision-making, and rapid institution of therapy can be lifesaving.
Although acute viral meningitis has usually a benign course, it requires hospitalization in some patients. The development of the polymerase chain reaction (PCR) has allowed the detection of viral genomes, facilitated a rapid diagnosis, and enabled the use of antiviral treatment in selected cases. Common etiologies include enteroviruses, followed by arboviruses and herpesviruses. Clinical presentation is not specific and includes fever, headache, and variable evidence of meningeal irritation. Prognosis overall is favorable.
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References
Tunkel AR, van de Beek D, Scheld WM. Acute meningitis. In: Mandell GL, Bennet JE, Dolin R, editors. Principles and practice of infectious diseases. 7th ed. Philadelphia: Churchill Livingstone/Elsevier; 2010. p. 1189–229.
Studhal M, Lindquist L, Erikson BM, Günther G, Bengner M, Franzen-Röhl E, et al. Acute viral infections of the central nervous system in immunocompetent adults: diagnosis and management. Drugs. 2013;73:131–58.
Roos KL, Tyler KL. Meningitis, encephalitis, brain abscess, and empyema. In: Kasper H, Braunwald L, Fauci J, editors. Principles internal medicine. 16th ed. New York: McGraw Hill; 2005. p. 2471–90.
Martin NG, Iro M, Sadarangani M, Galdacre R, Pollard AJ, Goldacre MJ. Hospital admissions for viral meningitis in children in England over five decades: a population-based observational study. Lancet Infect Dis. 2016;16:1279–87.
Jhekwaba UK, Kudesia G, McKendrick M. Clinical features of viral meningitis in adults: significant differences in cerebrospinal fluid findings among herpes simplex virus, varicella zoster virus, and enterovirus infections. Clin Infect Dis. 2008;47:783–9.
Navarro Mari JM, Pérez Ruiz M, Vicente AD. Diagnóstico de laboratorio de las meningitis linfocitarias. Enferm Infecc Microbiol Clin. 2010;28(Suppl 1):56–61.
Perez-Ruiz M, Vicente D, Navarro-Marà JM. Infecciones agudas del sistema nervioso central (meningitis y encefalitis) virales y bacterianas de origen autóctono. Enferm Infecc Microbiol Clin. 2008;26(Suppl 9):8–14.
Desmond RA, Accortt NA, Talley L, Villano SA, Soong SJ, Whitley RJ. Enteroviral meningitis: natural history and outcome of pleconaril therapy. Antimicrob Agents Chemother. 2006;50(7):2409–14.
Perez C, Oña M, Ballesteros S, Llaneza J, Lagunilla L, Perez S, et al. Meningitis por Enterovirus. CaracterÃsticas epidemiológicas, clÃnicas y de laboratorio en una serie de 60 niños. An Esp Pediatr. 2001;55:11–4.
Shalabi M, Whitley RJ. Recurrent benign lymphocytic meningitis. Clin Infect Dis. 2006;43:1194–7.
Berger JR, Houff S. Neurological complications of herpes simplex virus type 2 infection. Arch Neurol. 2008;65:596–600.
Mueller NH, Gilden DH, Cohrs RJ, Mahalingam R, Nagel MA. Varicella zoster virus infection: clinical features, molecular pathogenesis of disease, and latency. Neurol Clin. 2008;26:675–97.
Steiner I, Budka H, Chaudhuri A, Koskiniemi M, Sainio K, Salonen O, et al. Viral meningoencephalitis: a review of diagnostic methods and guidelines for management. Eur J Neurol. 2010;17:999–1009.
Hanson KE, Reckleff J, Hicks L, Castellano C, Hicks CB. Unsuspected HIV infection in patients presenting with acute meningitis. Clin Infect Dis. 2008;47:433–4.
Schacker T, Coller AC, Hughes J, Shea T, Corey L. Clinical and epidemiological features of primary HIV infection. Ann Intern Med. 1996;125(4):257–64.
Zavasky D-M, Gerberding JL, Sande MA. Patients with AIDS. In: Wilson WR, Sande MA, editors. Current diagnosis and treatment in infectious diseases. New York: McGraw Hill; 2001. p. 315–27.
Yung CF, Andrews N, Bukasa A, Brown KE, Ramsay M. Mumps complications and effects of mumps vaccination, England and Wales, 2002-2006. Emerg Infect Dis. 2011;17(4):661–7.
Escalza-Cortina I, Azkune-Calle I, Rodriguez-Sainz A, Gomez-Beldarrain M, Vicente-OlabarrÃa I, Garcia-Monco JC. Pearls and Oy-sters: chronic mumps meningoencephalitis with low CSF glucose and acute hydrocephalus in an adult. Neurology. 2014;82:e41–3.
Hviid A, Rubin S, Muhlemann K. Mumps. Lancet. 2008;371:932–44.
Centers for Disease Control and Prevention (CDC). Brief report: lymphocytic choriomeningitis virus transmitted through solid organ transplantation. MMWR Morb Mortal Wkly Rep. 2008;57(29):799–801.
Fisher SA, Graham MB, Kuehnert MJ, Kotton CN, Srinivasan A, Marty FM, et al. Transmission of lymphocytic choriomeningitis virus by organ transplantation. N Engl J Med. 2006;354(21):2235–49.
Amman BR, Pavlin BI, Albariño CG, Comer JA, Erickson BR, Oliver JB, et al. Pet rodents and fatal lymphocytic choriomeningitis in transplant meningitis. Emerg Infect Dis. 2007;13(5):719–25.
Kotton CN. Zoonosis in solid-organ and hematopoietic stem cell transplant recipients. Clin Infect Dis. 2007;44:857–66.
Drew WL. Viral infection of the central nervous system. In: Wilson WR, Sande MA, editors. Current diagnosis and treatment in infectious diseases. New York: McGraw-Hill; 2001. p. 315–27.
Solomon T. Flavivirus encephalitis. N Engl J Med. 2004;351:370–8.
Sánchez-Seco MP, Navarro JM. Infecciones por el virus de Toscana, el virus del Nilo Occidental y otros Arbovirus de interés en Europa. Enferm Infecc Microbiol Clin. 2005;23(9):560–8.
Yeon Lee K. Enterovirus 71 infection and neurological complications. Korean J Pediatr. 2016;59(10):395–401.
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Pomar, V., Domingo, P. (2018). Acute Viral Meningitis. In: GarcÃa-Moncó, J. (eds) CNS Infections. Springer, Cham. https://doi.org/10.1007/978-3-319-70296-4_4
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DOI: https://doi.org/10.1007/978-3-319-70296-4_4
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