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Toxicity of Bone-Targeted Agents in Malignancy

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Side Effects of Medical Cancer Therapy

Abstract

The bisphosphonates have been in clinical use for three decades. During this time the adverse event profile and favorable risk-benefit ratio have become clearly defined and strategies identified for minimizing the impact of these side effects on patients. More recently, denosumab has been incorporated into clinical practice and so far demonstrated mild and treatable side effects. Long-term adverse events are infrequent but merit special attention.

In this chapter we review the side effects of the four bisphosphonates licensed for use in malignancy, including clodronate, ibandronate, pamidronate, and zoledronic acid as well as the new targeted agent, denosumab.

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Authors and Affiliations

  1. Academic Unit of Clinical Oncology, Weston Park Hospital, University of Sheffield, Sheffield, UK

    Caroline Wilson, Fiona Taylor & Robert Coleman

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  1. Caroline Wilson
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  2. Fiona Taylor
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Correspondence to Robert Coleman .

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Editors and Affiliations

  1. Department of Hematology-Oncology, Centre Hospitalier de Luxembourg, Luxembourg, Luxembourg

    Mario A. Dicato

  2. Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium

    Eric Van Cutsem

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Wilson, C., Taylor, F., Coleman, R. (2018). Toxicity of Bone-Targeted Agents in Malignancy. In: Dicato, M., Van Cutsem, E. (eds) Side Effects of Medical Cancer Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-70253-7_17

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