Sexual Dimorphism and Estrogen Action in Mouse Liver

  • Sara Della Torre
  • Federica Lolli
  • Paolo Ciana
  • Adriana Maggi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1043)


Recent studies have demonstrated that in mice, the estrogen receptor alpha (ERα) is expressed in the liver and has a direct effect on the regulation of the hepatic genes relevant for energy metabolism and drug metabolism. The sex-related differential expression of the hepatic ERα raises the questions as to whether this receptor is responsible for the sexual differences observed in the physiopathology of the liver.


Liver Energy metabolism Fertility Female mammals Sexual differentiation Sex differences Sex-related diseases 

List of Abbreviations


Amino acids




Estrogen receptor alpha






Very-low-density lipoproteins



This work was supported by a grant from the European Community (ERC-Advanced Grant Ways 322977) and by Cariplo Foundation (Grant 2013-0786).


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Sara Della Torre
    • 1
  • Federica Lolli
    • 1
  • Paolo Ciana
    • 1
  • Adriana Maggi
    • 1
  1. 1.Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological and Biomolecular Sciences, University of MilanMilanItaly

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