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Sexual Dimorphism and Estrogen Action in Mouse Liver

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Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1043))

Abstract

Recent studies have demonstrated that in mice, the estrogen receptor alpha (ERα) is expressed in the liver and has a direct effect on the regulation of the hepatic genes relevant for energy metabolism and drug metabolism. The sex-related differential expression of the hepatic ERα raises the questions as to whether this receptor is responsible for the sexual differences observed in the physiopathology of the liver.

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Abbreviations

AA:

Amino acids

CARB:

Carbohydrates

ERα:

Estrogen receptor alpha

L:

Lipids

SC:

Subcutaneous

VLDL:

Very-low-density lipoproteins

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Acknowledgments

This work was supported by a grant from the European Community (ERC-Advanced Grant Ways 322977) and by Cariplo Foundation (Grant 2013-0786).

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Authors and Affiliations

  1. Center of Excellence on Neurodegenerative Diseases and Department of Pharmacological and Biomolecular Sciences, University of Milan, Milan, MI, Italy

    Sara Della Torre, Federica Lolli, Paolo Ciana & Adriana Maggi

Authors
  1. Sara Della Torre
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  2. Federica Lolli
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  3. Paolo Ciana
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  4. Adriana Maggi
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Corresponding author

Correspondence to Adriana Maggi .

Editor information

Editors and Affiliations

  1. Department of Medicine, Section of Endocrinology and Metabolism, Tulane University Health Sciences Center, School of Medicine, New Orleans, Louisiana, USA

    Franck Mauvais-Jarvis

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Della Torre, S., Lolli, F., Ciana, P., Maggi, A. (2017). Sexual Dimorphism and Estrogen Action in Mouse Liver. In: Mauvais-Jarvis, F. (eds) Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity. Advances in Experimental Medicine and Biology, vol 1043. Springer, Cham. https://doi.org/10.1007/978-3-319-70178-3_8

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