Sexual Dimorphism and Estrogen Action in Mouse Liver
Recent studies have demonstrated that in mice, the estrogen receptor alpha (ERα) is expressed in the liver and has a direct effect on the regulation of the hepatic genes relevant for energy metabolism and drug metabolism. The sex-related differential expression of the hepatic ERα raises the questions as to whether this receptor is responsible for the sexual differences observed in the physiopathology of the liver.
KeywordsLiver Energy metabolism Fertility Female mammals Sexual differentiation Sex differences Sex-related diseases
List of Abbreviations
Estrogen receptor alpha
This work was supported by a grant from the European Community (ERC-Advanced Grant Ways 322977) and by Cariplo Foundation (Grant 2013-0786).
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