The Role of Skeletal Muscle Estrogen Receptors in Metabolic Homeostasis and Insulin Sensitivity

  • Andrea L. Hevener
  • Zhenqi Zhou
  • Brian G. Drew
  • Vicent Ribas
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1043)


Women in the modern era are challenged with facing menopausal symptoms as well as heightened disease risk associated with increasing adiposity and metabolic dysfunction for up to three decades of life. Treatment strategies to combat metabolic dysfunction and associated pathologies have been hampered by our lack of understanding regarding the biological causes of these clinical conditions and our incomplete understanding regarding the effects of estrogens and the tissue-specific functions and molecular actions of its receptors. In this chapter we provide evidence supporting a critical and protective role for skeletal muscle estrogen receptor α in the maintenance of metabolic homeostasis and insulin sensitivity. Studies identifying the critical ER-regulated pathways essential for disease prevention will lay the important foundation for the rational design of novel therapeutic strategies to improve the health of women while limiting secondary complications that have plagued traditional hormone replacement interventions.


Estrogen receptors Insulin resistance Metabolic dysfunction Obesity 



This work was supported by grants from National Institutes of Health DK89109 and DK063491, NIH Nuclear Receptor Signaling Atlas (NURSA NDSP), UCLA Department of Medicine, UCLA Iris-Cantor Women’s Health Foundation, and the UCLA Jonsson Comprehensive Cancer Center. We would like to acknowledge all of the terrific science performed on ERα by many of our esteemed colleagues; however due to page limits we are unable to cite a large number of studies. We would like to take this opportunity to thank Dr. Kenneth Korach for his generous support of our research and for providing us with the ERα floxed mouse as well as a variety of powerful molecular tools.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Andrea L. Hevener
    • 1
  • Zhenqi Zhou
    • 1
  • Brian G. Drew
    • 1
  • Vicent Ribas
    • 1
  1. 1.Department of Medicine, Division of Endocrinology, Diabetes and HypertensionDavid Geffen School of Medicine, University of CaliforniaLos AngelesUSA

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