Abstract
Precise thyroid nodule classification is a key issue in endocrine clinic domain, which can enhance a patient’s chance for survival. The reports of type-B ultrasound examination are important data source for thyroid nodule classification, and patients with thyroid nodules normally undergo several periodic ultrasound examinations during the process of diagnosis and treatment. However, most of the existing methods rely on feature engineering of single ultrasound reports and they did not take into consideration the historical records of the patients. In this paper, we propose a Hierarchical Recurrent Neural Network (HRNN) for thyroid nodule classification using historical ultrasound reports. HRNN consists of three layers of Long Short-Term Memory (LSTM) Neural Networks. Each LSTM layer is trained to produce the higher-level representations. We evaluate HRNN on real-world thyroid nodule ultrasound reports. The experiment results show that HRNN outperforms the baseline models with ultrasound reports.
References
Burman, K., Wartofsky, L.: Clinical practice. Thyroid nodules. N. Engl. J. Med. 373(24), 2347 (2015)
Chen, W., Zheng, R., Baade, P.D., Zhang, S., Zeng, H., Bray, F., Jemal, A., Yu, X.Q., He, J.: Cancer statistics in china, 2015. CA: Cancer J. Clin. 66(2), 115–132 (2016)
Haugen, B.R., Alexander, E.K., Bible, K.C., Doherty, G.M., Mandel, S.J., Nikiforov, Y.E., Pacini, F., Randolph, G.W., Sawka, A.M., Schlumberger, M., et al.: 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid 26(1), 1–133 (2016)
Joachims, T.: Text categorization with support vector machines: learning with many relevant features. In: Nédellec, C., Rouveirol, C. (eds.) ECML 1998. LNCS, vol. 1398, pp. 137–142. Springer, Heidelberg (1998). doi:10.1007/BFb0026683
McCallum, A., Nigam, K., et al.: A comparison of event models for naive bayes text classification. In: AAAI 1998 Workshop on Learning for Text Categorization, vol. 752, pp. 41–48. Madison, WI (1998)
Breiman, L.: Random forests. Mach. Learn. 45(1), 5–32 (2001)
Alghoson, A.M.: Medical document classification based on mesh. In: 47th Hawaii International Conference on System Sciences, HICSS 2014, Waikoloa, HI, USA, 6–9 January 2014, pp. 2571–2575 (2014)
Tran, T., Luo, W., Phung, D.Q., Gupta, S.K., Rana, S., Kennedy, R., Larkins, A., Venkatesh, S.: A framework for feature extraction from hospital medical data with applications in risk prediction. BMC Bioinform. 15, 6596 (2014)
Hochreiter, S., Schmidhuber, J.: Long short-term memory. Neural Comput. 9(8), 1735–1780 (1997)
Hughes, M., Li, I., Kotoulas, S., Suzumura, T.: Medical text classification using convolutional neural networks (2017). CoRR abs/1704.06841
Miotto, R., Li, L., Dudley, J.T.: Deep learning to predict patient future diseases from the electronic health records. In: Ferro, N., Crestani, F., Moens, M.-F., Mothe, J., Silvestri, F., Di Nunzio, G.M., Hauff, C., Silvello, G. (eds.) ECIR 2016. LNCS, vol. 9626, pp. 768–774. Springer, Cham (2016). doi:10.1007/978-3-319-30671-1_66
Bengio, Y., Ducharme, R., Vincent, P., Janvin, C.: A neural probabilistic language model. J. Mach. Learn. Res. 3, 1137–1155 (2003)
Socher, R., Perelygin, A., Wu, J.Y., Chuang, J., Manning, C.D., Ng, A.Y., Potts, C., et al.: Recursive deep models for semantic compositionality over a sentiment treebank. In: Proceedings of the Conference on Empirical Methods in Natural Language Processing (EMNLP), vol. 1631, p. 1642 (2013)
Mikolov, T., Sutskever, I., Chen, K., Corrado, G.S., Dean, J.: Distributed representations of words and phrases and their compositionality. In: Advances in Neural Information Processing Systems 26: 27th Annual Conference on Neural Information Processing Systems 2013 and Proceedings of a meeting held 5–8 December 2013, Lake Tahoe, Nevada, United States. pp. 3111–3119 (2013)
Acknowledgments
This work was supported by the Shanghai Innovation Action Project of Science and Technology (15511106900), the Science and Technology Development Foundation of Shanghai (16JC1400802), and the Shanghai Specific Fund Project for Information Development (XX-XXFZ-01-14-6349).
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Chen, D., Shi, C., Wang, M., Pan, Q. (2017). Thyroid Nodule Classification Using Hierarchical Recurrent Neural Network with Multiple Ultrasound Reports. In: Liu, D., Xie, S., Li, Y., Zhao, D., El-Alfy, ES. (eds) Neural Information Processing. ICONIP 2017. Lecture Notes in Computer Science(), vol 10638. Springer, Cham. https://doi.org/10.1007/978-3-319-70139-4_77
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DOI: https://doi.org/10.1007/978-3-319-70139-4_77
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