Skip to main content

Abstract

The genus Eimeria belongs to Coccidia, and its parasite species reside usually in the intestine of their respective host. They are strictly host-specific and characterized by a monoxenous life cycle. After endogenous development, oocysts are excreted into the environment where they mature into the infective stage. Due to their widespread distribution in populations of many different animal species and because one animal host can be infected by a variety of Eimeria spp., they are considered of great veterinary importance. Mainly poultry, cattle, and sheep industries incur significant economic losses due to eimeriosis. It is important to differentiate between Eimeria spp., since only some are highly pathogenic, while many are nonpathogenic. In farm animals and pets, mainly young animals are affected by a high parasite burden and the intracellular parasite replication results in pathology and the development of eimeriosis as clinical disease. Eimeria destroys host cells during asexual and sexual replication leading to marked tissue damage in susceptible hosts. The infection by intestinal Eimeria spp. is associated with diarrhea, exsiccosis, anorexia, and other symptoms entailing a reduced animal performance as well as cases of death. An Eimeria infection is detected by the demonstration of oocysts in fecal samples and subsequently differentiated based on oocyst morphology. In the case of chicken, the diagnosis is usually confirmed by diagnostic dissections. Currently, control of Eimeria spp. is mainly carried out by hygienic measures such as cleaning and disinfection, general herd health management, and application of pathogen-specific interventions like metaphylactic anticoccidial drug treatment. Currently, Eimeria species-specific vaccination is only available for poultry. Eimeriosis of farm animals is a herd-health issue requiring strategic control measures.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abdel-Haleem HM, Al-Quraishy S, Abdel-Baki AA. Redescription and new locality record of Choleoeimeria turcicus from the gallbladder of Hemidactylus turcicus in Egypt, with notes on its endogenous development. Parasitol Res. 2016;115(5):2017–21. https://doi.org/10.1007/s00436-016-4945-1.

    Article  PubMed  Google Scholar 

  • Abu-Akkada SS, Awad AM. Isolation, propagation, identification and comparative pathogenicity of five Egyptian field strains of Eimeria tenella from broiler chickens in five different provinces in Egypt. Res Vet Sci. 2012;92:92–5. https://doi.org/10.1016/j.rvsc.2010.10.023.

    Article  PubMed  Google Scholar 

  • Allen PC, Fetterer RH. Recent advances in biology and immunobiology of Eimeria species and in diagnosis and control of infection with these coccidian parasites of poultry. Clin Microbiol Rev. 2002;15(1):58–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Allen PC, Jenkins MC. Observations on the gross pathology of Eimeria praecox infections in chickens. Avian Dis. 2010;54(2):834–40.

    Article  CAS  PubMed  Google Scholar 

  • Alnassan AA, Kotsch M, Shehata AA, Krüger M, Daugschies A, Bangoura B. Necrotic enteritis in chickens: development of a straightforward disease model system. Vet Rec. 2014;174(22):555–61.

    Article  CAS  PubMed  Google Scholar 

  • Alnassan AA, Thabet A, Daugschies A, Bangoura B. In vitro efficacy of allicin on chicken Eimeria tenella sporozoites. Parasitol Res. 2015;114(10):3913–5. https://doi.org/10.1007/s00436-015-4637-2.

    Article  PubMed  Google Scholar 

  • Al-Natour MQ, Suleiman MM, Abo-Shehada MN. Flock-level prevalence of Eimeria species among broiler chicks in northern Jordan. Prev Vet Med. 2002;53(4):305–10.

    Article  PubMed  Google Scholar 

  • Anderson WI, Giambrone JJ, Fletcher OJ Jr, Eidson CS, Reid WM. Demonstration of Eimeria tenella in bursa of Fabricius of chickens. Avian Dis. 1976;20(4):752–5.

    Article  CAS  PubMed  Google Scholar 

  • Baba E, Kawamoto K, Fukata T, Arakawa A. Possibilities of bacteremia and toxemia in death of chickens infected with Eimeria tenella. Avian Dis. 1990;34:566–70.

    Article  CAS  PubMed  Google Scholar 

  • Balicka-Ramisz A, Pilarczyk B. Occurrence of coccidia infection in pigeons in amateur husbandry. Diagnosis and prevention. Ann Parasitol. 2014;60(2):93–7.

    PubMed  Google Scholar 

  • Bangoura B, Daugschies A. Parasitological and clinical parameters of experimental Eimeria zuernii infection in calves and influence on weight gain and haemogram. Parasitol Res. 2007;100(6):1331–40.

    Article  CAS  PubMed  Google Scholar 

  • Bangoura B, Mundt HC, Schmäschke R, Westphal B, Daugschies A. Prevalence of Eimeria bovis and Eimeria zuernii in German cattle herds and factors influencing oocyst excretion. Parasitol Res. 2012;110(2):875–81. https://doi.org/10.1007/s00436-011-2569-z.

    Article  PubMed  Google Scholar 

  • Barker IK, Remmler O. Experimental Eimeria leuckarti infection in ponies. Vet Rec. 1970;86(15):448.

    Article  CAS  PubMed  Google Scholar 

  • Beelitz P, Göbel E, Gothe R. Endoparasites of donkeys and horses kept in communal housing in upper Bavaria; species spectrum and incidence. Tierarztl Prax. 1996;24(5):471–5.

    CAS  PubMed  Google Scholar 

  • Benbrook EA, Sloss MW. Coccidial oocysts (Eimeria leuckarti) from north American donkeys (Asinus asinus). J Am Vet Med Assoc. 1962;140:817–8.

    CAS  PubMed  Google Scholar 

  • Blake DP, Tomley FM. Securing poultry production from the ever-present Eimeria challenge. Trends Parasitol. 2014;30:12–9. https://doi.org/10.1016/j.pt.2013.10.003.

    Article  PubMed  Google Scholar 

  • Blandino T. Assessment of formaldehyde effectiveness on Eimeria zurnii oocysts under simulated field conditions. Rvsta Cub Cien Vet. 1985;16(1):67–71.

    Google Scholar 

  • Britton WM, Hill CH, Barber CW. A mechanism of interaction between dietary protein levels and coccidiosis in chicks. J Nutr. 1964;82:306–10.

    Article  CAS  PubMed  Google Scholar 

  • Catchpole J, Norton CC, Gregory MW. Immunisation of lambs against coccidiosis. Vet Rec. 1993;132(3):56–9.

    Article  CAS  PubMed  Google Scholar 

  • Chapman HD. Coccidiosis in the turkey. Avian Pathol. 2008;37(3):205–23. https://doi.org/10.1080/03079450802050689.

    Article  CAS  PubMed  Google Scholar 

  • Chapman HD, Jeffers TK. Vaccination of chickens against coccidiosis ameliorates drug resistance in commercial poultry production. Int J Parasitol Drugs Drug Resist. 2014;4(3):214–7. https://doi.org/10.1016/j.ijpddr.2014.10.002.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chapman HD, Cherry TE, Danforth HD, Richards G, Shirley MW, Williams RB. Sustainable coccidiosis control in poultry production: the role of live vaccines. Int J Parasitol. 2002;32:617–29.

    Article  CAS  PubMed  Google Scholar 

  • Chauve CM, Gastellu J, Reynaud MC. Pathogenicity of Eimeria mulardi Chauve et al., 1994 in experimentally infected mule-ducks. Precision on pathological stages. Avian Pathol. 1994;23(3):557–68.

    Article  CAS  PubMed  Google Scholar 

  • Chengat Prakashbabu B, Thenmozhi V, Limon G, Kundu K, Kumar S, Garg R, Clark EL, Srinivasa Rao AS, Raj DG, Raman M, Banerjee PS, Tomley FM, Guitian J, Blake DP. Eimeria species occurrence varies between geographic regions and poultry production systems and may influence parasite genetic diversity. Vet Parasitol. 2017;233:62–72. https://doi.org/10.1016/j.vetpar.2016.12.003.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Clark EL, Tomley FM, Blake DP. Are Eimeria genetically diverse, and does it matter? Trends Parasitol. 2017;33(3):231–41. https://doi.org/10.1016/j.pt.2016.08.007.

    Article  PubMed  Google Scholar 

  • Clarkson MJ, Gentles MA. Coccidiosis in turkeys. Vet Rec. 1958;70:211–4.

    Google Scholar 

  • Collier CT, Hofacre CL, Payne AM, Anderson DB, Kaiser P, Mackie RI, Gaskins HR. Coccidia-induced mucogenesis promotes the onset of necrotic enteritis by supporting Clostridium perfringens growth. Vet Immunol Immunopathol. 2008;122:104–15.

    Article  CAS  PubMed  Google Scholar 

  • Constantinoiu CC, Molloy JB, Jorgensen WK, Coleman GT. Development and validation of an ELISA for detecting antibodies to Eimeria tenella in chickens. Vet Parasitol. 2007;150(4):306–13.

    Article  CAS  PubMed  Google Scholar 

  • Cornelissen AWCA, Verstegen R, van den Brand H, Perie NM, Eysker M, Lam TJGM, Pijpers A. An observational study of Eimeria species in housed cattle on Dutch dairy farms. Vet Parasitol. 1995;56:7–16.

    Article  CAS  PubMed  Google Scholar 

  • Courtney CH, Ernst JV, Benz GW. Redescription of oocysts of the bovine coccidia Eimeria bukidnonensis Tubangui 1931 and E. wyomingensis Huizinga and winger 1942. J Parasitol. 1976;62(3):372–6.

    Article  CAS  PubMed  Google Scholar 

  • Cowper B, Matthews S, Tomley F. The molecular basis for the distinct host and tissue tropisms of coccidian parasites. Mol Biochem Parasitol. 2012;186(1):1–10. https://doi.org/10.1016/j.molbiopara.2012.08.007.

    Article  CAS  PubMed  Google Scholar 

  • Dai Y, Liu M, Tao JP, Li WL, Ding C, Liu XX. Survey on coccidia of domestic geese and their experimental infections. J Xiamen Univ (Nat Sci). 2004;42:228–33.

    Google Scholar 

  • Dai Y, Liu X, Liu M, Tao J. The life cycle and pathogenicity of coccicium Eimeria nocens (Kotlán, 1933) in domestic goslings. J Parasitol. 2005;91(5):1122–6.

    Article  PubMed  Google Scholar 

  • Daszak P. Zoite migration during Eimeria tenella infection: parasite adaptation to host defences. Parasitol Today. 1999;15:67–72.

    Article  CAS  PubMed  Google Scholar 

  • Daugschies A, Najdrowski M. Eimeriosis in cattle: current understanding. J Vet Med B Infect Dis Vet Public Health. 2005;52(10):417–27.

    Article  CAS  PubMed  Google Scholar 

  • Daugschies A, Akimaru M, Bürger HJ. Experimental Eimeria bovis infections in the calf: 1. Parasitologic and clinical findings. Dtsch Tierarztl Wochenschr. 1986;93(9):393–7.

    CAS  PubMed  Google Scholar 

  • Daugschies A, Imarom S, Ganter M, Bollwahn W. Prevalence of Eimeria spp. in sows at piglet-producing farms in Germany. J Vet Med B Infect Dis Vet Public Health. 2004;51(3):135–9.

    Article  CAS  PubMed  Google Scholar 

  • Daugschies A, Bangoura B, Lendner M. Inactivation of exogenous endoparasite stages by chemical disinfectants: current state and perspectives. Parasitol Res. 2013;112(3):917–32. https://doi.org/10.1007/s00436-013-3324-4.

    Article  PubMed  Google Scholar 

  • Davis LR, Bowman GW, Boughton DC. The endogenous development of Eimeria alabamensis Christensen, 1941, an intranuclear coccidium of cattle. J Protozool. 1957;4(4):219–25.

    Article  Google Scholar 

  • Dhama K, Verma AK, Rajagunalan S, Kumar A, Tiwari R, Chakraborty S, Kumar R. Listeria monocytogenes infection in poultry and its public health importance with special reference to food borne zoonoses. Pak J Biol Sci. 2013;16:301–8.

    Article  PubMed  Google Scholar 

  • Ding X, Lillehoj HS, Dalloul RA, Min W, Sato T, Yasuda A, Lillehoj EP. In ovo vaccination with the Eimeria tenella EtMIC2 gene induces protective immunity against coccidiosis. Vaccine. 2005;23:3733–40.

    Article  CAS  PubMed  Google Scholar 

  • Doran DJ, Farr MM. Excystation of the poultry coccidium, Eimeria acervulina. J Protozoo. 1962;l9:154–61.

    Article  Google Scholar 

  • Dubremetz JF, Elsner YY. Ultrastructural study of schizogony of Eimeria bovis in cell cultures. J Protozool. 1979;26(3):367–76.

    Article  CAS  PubMed  Google Scholar 

  • Ellis PA, Wright AE. Coccidiosis in guinea-pigs. J Clin Pathol. 1961;14(4):394–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Enemark HL, Dahl J, Enemark JM. Significance of timing on effect of Metaphylactic Toltrazuril treatment against Eimeriosis in calves. Parasitol Res. 2015;114(Suppl 1):S201–12. https://doi.org/10.1007/s00436-015-4526-8.

    Article  PubMed  Google Scholar 

  • Epe C, von Samson-Himmelstjerna G, Wirtherle N, von der Heyden V, Welz C, Beening J, Radeloff I, Hellmann K, Schnieder T, Krieger K. Efficacy of toltrazuril as a metaphylactic and therapeutic treatment of coccidiosis in first-year grazing calves. Parasitol Res. 2005;97(Suppl 1):S127–33.

    Article  PubMed  Google Scholar 

  • Ernst JV, Benz GW. Coccidiosis. Curr Top Vet Med Anim Sci. 1981;6:377–92.

    Google Scholar 

  • Faber JE, Kollmann D, Heise A, Bauer C, Failing K, Bürger HJ, Zahner H. Eimeria infections in cows in the periparturient phase and their calves: oocyst excretion and levels of specific serum and colostrum antibodies. Vet Parasitol. 2002;104(1):1–17.

    Article  CAS  PubMed  Google Scholar 

  • Farr MM, Wehr EE. Survival of Eimeria acervulina, E. tenella and E. maxima oocysts on soil under various field conditions. Ann N Y Acad Sci. 1949;52:468–72.

    Article  Google Scholar 

  • Fernandez I, Benito J, Pardos F. Ultrastructure of the oocyst wall formation in Eimeria beauchampi leger and Duboscq, 1917, a coccidian parasite of Glossobalanus minutus (Kow.) (Enteropneusta, Hemichordata). Ann Parasitol Hum Comp. 1988;63(4):253–62.

    Article  CAS  PubMed  Google Scholar 

  • Fitzgerald PR. The economic impact of coccidiosis in domestic animals. Adv Vet Sci Comp Med. 1980;24:121–43.

    CAS  PubMed  Google Scholar 

  • Flausino G, Berto BP, Mcintosh D, Furtado TT, Teixeira WL, Lopes CWG. Phenotypic and genotypic characterization of Eimeria caviae from Guinea pigs (Cavia porcellus). Acta Protozool. 2014;53(3):269–76.

    Google Scholar 

  • Florião MM, Lopes Bdo B, Berto BP, Lopes CW. New approaches for morphological diagnosis of bovine Eimeria species: a study on a subtropical organic dairy farm in Brazil. Trop Anim Health Prod. 2016;48(3):577–84. https://doi.org/10.1007/s11250-016-0998-5.

    Article  PubMed  Google Scholar 

  • Foreyt WJ. Coccidiosis and cryptosporidiosis in sheep and goats. Vet Clin North Am Food Anim Pract. 1990;6(3):655–70.

    Article  CAS  PubMed  Google Scholar 

  • Friend SC, Stockdale PH. Experimental Eimeria bovis infection in calves: a histopathological study. Can J Comp Med. 1980;44(2):129–40.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Gajadhar AA, Wobeser G, Stockdale PHG. Coccidia of domestic and wild waterfowl (Anseriformes). Can J Zool. 1983;61:1–24.

    Article  Google Scholar 

  • Gaudie CM, Evans RJ, Done SH. Coccidiosis in replacement gilts. Vet Rec. 2005;157(17):517–8.

    Article  CAS  PubMed  Google Scholar 

  • Gerken M, Renieri C. South American Camelids research: proceedings of the 4th European symposium on south American Camelids and DECAMA European seminar, Göttingen, 7–9 October 2004, vol. 1. Wageningen: Wageningen Academic; 2006.

    Google Scholar 

  • Giambrone JJ, Anderson WI, Reid WM, Eidson CS. Effect of infectious bursal disease on the severity of Eimeria tenella infections in broiler chicks. Poult Sci. 1977;56:243–6.

    Article  CAS  PubMed  Google Scholar 

  • Giambrone JJ, Klesius PH, Eckamn MK, Edgar SA. Influence of hormonal and chemical bursectomy on the development of acquired immunity to coccidia in broiler chickens. Poult Sci. 1981;60:2612–8.

    Article  CAS  PubMed  Google Scholar 

  • Gomez-Bautista M, Rojo-Vazquez FA, Alunda JM. The effect of the host’s age on the pathology of Eimeria stiedai infection in rabbits. Vet Parasitol. 1987;24(1-2):47–57.

    Article  CAS  PubMed  Google Scholar 

  • Graat EA, van der Kooij E, Frankena K, Henken AM, Smeets JF, Hekerman MT. Quantifying risk factors of coccidiosis in broilers using on-farm data based on a veterinary practice. Prev Vet Med. 1998;33:297–308.

    Article  CAS  PubMed  Google Scholar 

  • Gräfner G, Graubmann HD, Kron A. About the epizoology of cattle coccidiosis in raising and fattening farms. Mh Vet Med. 1978;33:910–2.

    Google Scholar 

  • Gräfner G, Graubmann HD, Schwartz K, Hiepe T, Kron A. Further studies on the incidence, epidemiology and control of bovine Eimeria coccidiosis under intensive-rearing conditions. Mh Vet Med. 1985;40:41–4.

    Google Scholar 

  • Gregory MW. Some factors in the pathogenesis of intestinal coccidiosis in mammals. Parasitology. 1982;85:R3.

    Google Scholar 

  • Gregory MW, Catchipole J. Ovine coccidiosis: the pathology of Eimeria crandallis infection. Int J Parasitol. 1990;20(7):849–60.

    Article  CAS  PubMed  Google Scholar 

  • Gregory MW, Catchpole J. Ovine coccidiosis: pathology of Eimeria ovinoidalis infection. Int J Parasitol. 1987;17(6):1099–111.

    Article  CAS  PubMed  Google Scholar 

  • Gülegen E, Girisgin O, Girisgin AO, Cirak VY. Eimeria leuckarti infections in sport horses in Northwest Turkey. Berl Munch Tierärztl Wochenschr. 2016;129(1-2):52–5.

    PubMed  Google Scholar 

  • Györke A, Pop L, Cozma V. Prevalence and distribution of Eimeria species in broiler chicken farms of different capacities. Parasite. 2013;20:50. https://doi.org/10.1051/parasite/2013052.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hackstein JHP, Mackenstedt U, Mehlhorn H, Meijerink JPP, Schubert H, Leunissen JAM. Parasitic apicomplexans harbor a chlorophyll a-D1 complex, the potential target for therapeutic triazines. Parasitol Res. 1995;81:207–16.

    CAS  PubMed  Google Scholar 

  • Hamid PH, Hirzmann J, Kerner K, Gimpl G, Lochnit G, Hermosilla CR, Taubert A. Eimeria bovis infection modulates endothelial host cell cholesterol metabolism for successful replication. Vet Res. 2015;46:100. https://doi.org/10.1186/s13567-015-0230-z.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hammond DM, Bowman GW, Davis LR, Simms BT. The endogenous phase of the life cycle of Eimeria bovis. J Parasitol. 1946;32:409–27.

    Article  CAS  PubMed  Google Scholar 

  • Hammond DM, Andersen FL, Miner ML. The occurrence of a second asexual generation in the life cycle of Eimeria bovis in calves. J Parasitol. 1963;49:428–34.

    Article  CAS  PubMed  Google Scholar 

  • Hanada S, Omata Y, Umemoto Y, Kobayashi Y, Furuoka H, Matsui T, Maeda R, Saito A. Relationship between liver disorders and protection against Eimeria stiedai infection in rabbits immunized with soluble antigens from the bile of infected rabbits. Vet Parasitol. 2003;111(2-3):261–6.

    Article  CAS  PubMed  Google Scholar 

  • Hashemnia M, Khodakaram-Tafti A, Razavi SM, Nazifi S. Experimental caprine coccidiosis caused by Eimeria arloingi: morphopathologic and electron microscopic studies. Vet Res Commun. 2012;36(1):47–55. https://doi.org/10.1007/s11259-011-9511-9.

    Article  PubMed  Google Scholar 

  • Hegazy SH, Hassanein ZA, El-Sheshtawy EA, Awadalla SF. Effect of dual infections of Escherichia coli and pure caecal Eimeria sp in broiler chickens. J Egypt Soc Parasitol. 1999;29:859–72.

    CAS  PubMed  Google Scholar 

  • Hein H. Eimeria adenoeides and E. meleagrimitis: pathogenic effect in turkey poults. Exp Parasitol. 1969;24:163–70.

    Article  CAS  PubMed  Google Scholar 

  • Hermosilla C, Stamm I, Menge C, Taubert A. Suitable in vitro culture of Eimeria bovis meront II stages in bovine colonic epithelial cells and parasite-induced upregulation of CXCL10 and GM-CSF gene transcription. Parasitol Res. 2015;114(8):3125–36. https://doi.org/10.1007/s00436-015-4531-y.

    Article  PubMed  Google Scholar 

  • Hiepe T, Romeyke D, Jungmann R. Studies of coccidia infections in calves under intensive rearing conditions and recommendations for their control. Mh Vet Med. 1978;33:904–10.

    Google Scholar 

  • Hilbrich P. Disinfection tests on Eimeria tenella oocytes. Berl Münch Tierärztl Wochenschr. 1975;88:144–8.

    CAS  PubMed  Google Scholar 

  • Hill JE, Lomax LG, Lindsay DS, Lynn BS. Coccidosis caused by Eimeria scabra in a finishing hog. J Am Vet Med Assoc. 1985;186(9):981–3.

    CAS  PubMed  Google Scholar 

  • Hooshmand-Rad P, Svensson C, Uggla A. Experimental Eimeria alabamensis infection in calves. Vet Parasitol. 1994;53(1-2):23–32.

    Article  CAS  PubMed  Google Scholar 

  • Itagaki K. Further investigation on the mechanism of coccidial infection in fowl. J Fac Agric Tottori Univ. 1954;2:37–53.

    Google Scholar 

  • Jahn D, Matros A, Bakulina AY, Tiedemann J, Schubert U, Giersberg M, Haehnel S, Zoufal K, Mock HP, Kipriyanov SM. Model structure of the immunodominant surface antigen of Eimeria tenella identified as a target for sporozoite-neutralizing monoclonal antibody. Parasitol Res. 2009;105(3):655–68. https://doi.org/10.1007/s00436-009-1437-6.

    Article  PubMed  Google Scholar 

  • Jarvinen JA. Infection of llamas with stored Eimeria macusaniensis oocysts obtained from guanaco and alpaca feces. J Parasitol. 2008;94(4):969–72.

    Article  CAS  PubMed  Google Scholar 

  • Jenkins MC, Castle MD, Danforth HD. Protective immunization against the intestinal parasite Eimeria acervulina with recombinant coccidial antigen. Poult Sci. 1991;70(3):539–47.

    Article  CAS  PubMed  Google Scholar 

  • Jeurissen SH, Janse EM, Vermeulen AN, Vervelde L. Eimeria tenella infections in chickens: aspects of host-parasite interaction. Vet Immunol Immunopathol. 1996;54(1-4):231–8.

    Article  CAS  PubMed  Google Scholar 

  • Jing J, Liu C, Zhu SX, Jiang YM, LC W, Song HY, Shao YX. Pathological and ultrastructural observations and liver function analysis of Eimeria stiedai-infected rabbits. Vet Parasitol. 2016;223:165–72. https://doi.org/10.1016/j.vetpar.2016.04.020.

    Article  CAS  PubMed  Google Scholar 

  • Johnson J, Reid WM. Anticoccidial drugs: lesion scoring techniques in battery and floor-pen experiments with chickens. Exp Parasitol. 1970;28(1):30–6.

    Article  CAS  PubMed  Google Scholar 

  • Julian RJ, Harrison KB, Richardson JA. Nervous signs in bovine coccidiosis. Mod Vet Pract. 1976;57(9):711–2; 716, 718

    CAS  PubMed  Google Scholar 

  • Kabell S, Handberg KJ, Bisgaard M. Impact of coccidial infection on vaccine- and vvIBDV in lymphoid tissues of SPF chickens as detected by RT-PCR. Acta Vet Scand. 2006;48:17.

    Article  PubMed  PubMed Central  Google Scholar 

  • Karamon J, Ziomko I, Cencek T. Prevalence of Isospora suis and Eimeria spp. in suckling piglets and sows in Poland. Vet Parasitol. 2007;147(1-2):171–5.

    Article  PubMed  Google Scholar 

  • Katrib M, Ikin RJ, Brossier F, Robinson M, Slapetova I, Sharman PA, Walker RA, Belli SI, Tomley FM, Smith NC. Stage-specific expression of protease genes in the apicomplexan parasite, Eimeria tenella. BMC Genomics. 2012;13:685. https://doi.org/10.1186/1471-2164-13-685.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kefu Z, Yingying W, Mei C, Lihong W, Shuichun H, Jun Z, Renhai L, Hong X. Eimeria tenella: further studies on the development of the oocyst. Exp Parasitol. 2006;113(3):174–8.

    Article  PubMed  Google Scholar 

  • Kim ES, Hong YH, Min W, Lillehoj HS. Fine-mapping of coccidia-resistant quantitative trait loci in chickens. Poultry Sci. 2006;85(11):2028–30.

    Article  Google Scholar 

  • Koo BS, Lee HR, Jeon EO, Han MS, Min KC, Lee SB, Mo IP. Molecular survey of enteric viruses in commercial chicken farms in Korea with a history of enteritis. Poultry Sci. 2013;92:2876–85. https://doi.org/10.3382/ps.2013-03280.

    Article  CAS  Google Scholar 

  • Kouam MK, Meutchieye F, Nguafack TT, Miegoué E, Tchoumboué J, Theodoropoulos G. Parasitic fauna of domestic cavies in the western highlands of Cameroon (Central Africa). BMC Vet Res. 2015;2015(11):288. https://doi.org/10.1186/s12917-015-0605-4.

    Article  Google Scholar 

  • Koudela B, Vìtovec J. Biology and pathogenicity of Eimeria neodebliecki Vetterling, 1965 in experimentally infected pigs. Parasitol Int. 1998;47(4):249–56.

    Article  Google Scholar 

  • Kouwenhoven B, van der Horst CJ. Histological observations with respect to the immune mechanism in Eimeria acervulina infection in the domestic fowl. Z Parasitenkd. 1973;42(1):11–21.

    Article  CAS  PubMed  Google Scholar 

  • Krautwald-Junghanns ME, Zebisch R, Schmidt V. Relevance and treatment of coccidiosis in domestic pigeons (Columba livia forma domestica) with particular emphasis on toltrazuril. J Avian Med Surg. 2009;23(1):1–5.

    Article  PubMed  Google Scholar 

  • Kunstýr I, Naumann S. Laboratory animal diseases in pictures. Coccidiosis in guinea pigs; with emphasis on diagnosis. Z Versuchstierkd. 1981;23(4):255–7.

    PubMed  Google Scholar 

  • Kvičerová J, Hypša V. Host-parasite incongruences in rodent Eimeria suggest significant role of adaptation rather than cophylogeny in maintenance of host specificity. PLoS One. 2013;8:e63601.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lainson R. Intestinal coccidia (Apicomplexa: Eimeriidae) of Brazilian lizards. Eimeria carmelinoi n.sp., from Kentropyx calcarata and Acroeimeria paraensis n.sp. from Cnemidophorus lemniscatus lemniscatus (Lacertilia: Teiidae). Mem Inst Oswaldo Cruz. 2002;97(2):227–37.

    Article  PubMed  Google Scholar 

  • Lassen B, Ostergaard S. Estimation of the economical effects of Eimeria infections in Estonian dairy herds using a stochastic model. Prev Vet Med. 2012;106(3-4):258–65. https://doi.org/10.1016/j.prevetmed.2012.04.005. Epub 2012 May 17.

    Article  PubMed  Google Scholar 

  • Lassen B, Viltrop A, Raaperi K, Järvis T. Eimeria and Cryptosporidium in Estonian dairy farms in regard to age, species, and diarrhoea. Vet Parasitol. 2009;166(3–4):212–9.

    Article  PubMed  Google Scholar 

  • Lee MB, Lee EH. Coccidial contamination of raspberries: mock contamination with Eimeria acervulina as a model for decontamination treatment studies. J Food Prot. 2001;64(11):1854–7.

    Article  CAS  PubMed  Google Scholar 

  • Lee DL, Millard BJ. The structure and development of the macrogamete and oocyst of Eimeria acervulina. Parasitology. 1971;62(1):31–4.

    Article  CAS  PubMed  Google Scholar 

  • Levine ND. Protozoan parasites of domestic animals and of man. 1st ed. Minneapolis, MN: Burgess; 1961.

    Google Scholar 

  • Levine ND, Ivens V. The coccidian parasites (protozoa, sporozoa) of ruminants. Urbana, IL: University of Illinois Press; 1970.

    Book  Google Scholar 

  • Li G, Lillehoj HS, Lee KW, Jang SI, Marc P, Gay CG, Ritter GD, Bautista DA, Phillips K, Neumann AP, Rehberger TG, Siragusa GR. An outbreak of gangrenous dermatitis in commercial broiler chickens. Avian Pathol. 2010;39:247–53. https://doi.org/10.1080/03079457.2010.487517.

    Article  PubMed  Google Scholar 

  • Li J, Zheng J, Gong P, Zhang X. Efficacy of Eimeria tenella rhomboid-like protein as a subunit vaccine in protective immunity against homologous challenge. Parasitol Res. 2012;110:1139–45. https://doi.org/10.1007/s00436-011-2603-1.

    Article  PubMed  Google Scholar 

  • Lillehoj HS, Li G. Nitric oxide production by macrophages stimulated with coccidia sporozoites, lipopolysaccharide, or interferon-gamma, and its dynamic changes in SC and TK strains of chickens infected with Eimeria tenella. Avian Dis. 2004;48:244–53.

    Article  PubMed  Google Scholar 

  • Lillehoj HS, Trout JM. Avian gut-associated lymphoid tissues and intestinal immune responses to Eimeria parasites. Clin Microbiol Rev. 1996;9:349–60.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Lillehoj HS, Choi KD, Jenkins MC, Vakharia VN, Song KD, Han JY, Lillehoj EP. A recombinant Eimeria protein inducing interferon-gamma production: comparison of different gene expression systems and immunization strategies for vaccination against coccidiosis. Avian Dis. 2000;44:379–89.

    Article  CAS  PubMed  Google Scholar 

  • Lillehoj HS, Kim CH, Keeler CL Jr, Zhang S. Immunogenomic approaches to study host immunity to enteric pathogens. Poultry Sci. 2007;86:1491–500.

    Article  CAS  Google Scholar 

  • Liou CT, Wang JS, Ooi HK. Effect of ozone treatment on Eimeria colchici oocysts. J Parasitol. 2002;88:159–62.

    Article  CAS  PubMed  Google Scholar 

  • Liu Y, Zheng J, Li J, Gong P, Zhang X. Protective immunity induced by a DNA vaccine encoding Eimeria tenella rhomboid against homologous challenge. Parasitol Res. 2013;112:251–7. https://doi.org/10.1007/s00436-012-3132-2.

    Article  PubMed  Google Scholar 

  • Lobago F, Worku N, Wossene A. Study on coccidiosis in Kombolcha poultry farm, Ethiopia. Trop Anim Health Prod. 2005;37:245–51.

    Article  CAS  PubMed  Google Scholar 

  • Long PL. Pathology and pathogenicity of coccidial infection. In: Hammond DM, Long PL, editors. Eimeria, Isospora, Toxoplasma and related genera. Baltimore: University Park Press; 1973. p. 253–94.

    Google Scholar 

  • Lundén A, Thebo P, Gunnarsson S, Hooshmian-Rad P, Tauson R, Uggla A. Eimeria infections in litter-based, high stocking density systems for loose-housed laying hens in Sweden. Br Poult Sci. 2000;41:440–7.

    Article  PubMed  Google Scholar 

  • Lyons ET, Tolliver SC. Prevalence of parasite eggs (Strongyloides westeri, Parascaris equorum, and strongyles) and oocysts (Emeria leuckarti) in the feces of thoroughbred foals on 14 farms in central Kentucky in 2003. Parasitol Res. 2004;92(5):400–4.

    Article  CAS  PubMed  Google Scholar 

  • Marquardt WC. Effect of high temperature on sporulation of Eimeria zurnii. Exp Parasitol. 1960;10:58–65.

    Article  CAS  PubMed  Google Scholar 

  • Matjila PT, Penzhorn BL. Occurrence and diversity of bovine coccidia at three localities in South Africa. Vet Parasitol. 2002;104:93–102.

    Article  CAS  PubMed  Google Scholar 

  • Matsubayashi M, Hatta T, Miyoshi T, Anisuzzaman SK, Yamaji K, Shimura K, Isobe T, Kita K, Tsuji N. Localization of eimeripain, an Eimeria tenella cathepsin B-like cysteine protease, during asexual and sexual intracellular development in chicken ceca. J Vet Med Sci. 2014;76(4):531–7.

    Article  CAS  PubMed  Google Scholar 

  • Matsui T, Morii T, Iijima T, Kobayashi F, Fujino T. Transformation of oocysts from several coccidian species by heat treatment. Parasitol Res. 1989;75(4):264–7.

    Article  CAS  PubMed  Google Scholar 

  • McAllister CT, Scott Seville R, Hartdegen R. Two new species of coccidia (Apicomplexa: Eimeriidae) from leaf-tailed geckos, Uroplatus spp. (Sauria: Gekkonidae) from Madagascar, including a new host of Eimeria brygooi Upton & Barnard, 1987. Syst Parasitol. 2016;93(8):815–23. https://doi.org/10.1007/s11230-016-9660-x.

    Article  PubMed  PubMed Central  Google Scholar 

  • McDougald LR. Intestinal protozoa important to poultry. Poultry Sci. 1998;77:1156–8.

    Article  CAS  Google Scholar 

  • McKenna PB. Eimeria macusaniensis in camelids—a brief review. Surveillance. 2006;33(4):8–10.

    Google Scholar 

  • McQueary CA, Worley DE, Catlin JE. Observations on the life cycle and prevalence of Eimeria leuckarti in horses in Montana. Am J Vet Res. 1977;38(10):1673–4.

    CAS  PubMed  Google Scholar 

  • Megía-Palma R, Martínez J, Acevedo I, Martín J, García-Roa R, Ortega J, Peso-Fernández M, Albaladejo G, Cooper RD, Paranjpe DA, Sinervo BR, Merino S. Phylogeny of the reptilian Eimeria: are Choleoeimeria and Acroeimeria valid generic names? Zool Scr. 2015;44(6):684–92. https://doi.org/10.1111/zsc.12126.

    Article  Google Scholar 

  • Michael E, Hodges RD. The pathogenic effects of Eimeria acervulina: a comparison of single and repeated infections. Vet Rec. 1971;89(12):329–33.

    Article  CAS  PubMed  Google Scholar 

  • Ming-Hsien L, Hai-I H, Hong-Kean O. Prevalence, infectivity and oocyst sporulation time of rabbit-coccidia in Taiwan. Trop Biomed. 2010;27(3):424–9.

    CAS  PubMed  Google Scholar 

  • Mitchell ES, Smith RP, Ellis-Iversen J. Husbandry risk factors associated with subclinical coccidiosis in young cattle. Vet J. 2012;193(1):119–23. https://doi.org/10.1016/j.tvjl.2011.09.017.

    Article  CAS  PubMed  Google Scholar 

  • Morner R. Endoparasites of eider-ducklings (Somateria mollissima) on the Swedish east coast. In: Anderesson A, Fredga S, editors. Proceedings of the symposium on sea ducks, Stockholm, Sweden. Gloucester: International Waterfowl Research Bureau; 1975.

    Google Scholar 

  • Mouafo AN, Weck-Heimann A, Dubremetz JF, Entzeroth R. Monoclonal antibodies speciWc for the two types of wall-forming bodies of Eimeria tenella macrogametes (Coccidia, Apicomplexa). Parasitol Res. 2002;88:217–24.

    Article  PubMed  Google Scholar 

  • Mundt HC, Bangoura B, Rinke M, Rosenbruch M, Daugschies A. Pathology and treatment of Eimeria zuernii coccidiosis in calves: investigations in an infection model. Parasitol Int. 2005;54(4):223–30.

    Article  PubMed  Google Scholar 

  • Nation PN, Wobeser G. Renal coccidiosis in wild ducks in Saskatchewan. J Wildl Dis. 1977;13(4):370–5. https://doi.org/10.7589/0090-3558-13.4.370.

    Article  CAS  PubMed  Google Scholar 

  • Oakes RD, Kurian D, Bromley E, Ward C, Lal K, Blake DP, Reid AJ, Pain A, Sinden RE, Wastling JM, Tomley FM. The rhoptry proteome of Eimeria tenella sporozoites. Int J Parasitol. 2013;43(2):181–8. https://doi.org/10.1016/j.ijpara.2012.10.024.

    Article  CAS  PubMed  Google Scholar 

  • Oksanen A. Mortality associated with renal coccidiosis in juvenile wild greylag geese (Anser anser anser). J Wildl Dis. 1994;30(4):554–6.

    Article  CAS  PubMed  Google Scholar 

  • d’Ovidio D, Noviello E, Ianniello D, Cringoli G, Rinaldi L. Survey of endoparasites in pet guinea pigs in Italy. Parasitol Res. 2015;114(3):1213–6. https://doi.org/10.1007/s00436-014-4289-7.

    Article  PubMed  Google Scholar 

  • Ovington KS, Alleva LM, Kerr EA. Cytokines and immunological control of Eimeria spp. Int J Parasitol. 1995;25:1331–51.

    Article  CAS  PubMed  Google Scholar 

  • Pakandl M, Reynaud MC, Chauve CM. Electron microscopic study on the endogenous development of Eimeria mulardi, Chauve, Reynaud and Gounel, 1994: a coccidium from the mule duck. Parasitol Res. 2002;88(2):160–4.

    Article  CAS  PubMed  Google Scholar 

  • Paperna I, Landsberg JH. Description and taxonomic discussion of eimerian coccidia from African and Levantine geckoes. S Afr J Zool. 1989;24:345–55.

    Article  Google Scholar 

  • Passafaro TL, Carrera JP, dos Santos LL, Raidan FS, dos Santos DC, Cardoso EP, Leite RC, Toral FL. Genetic analysis of resistance to ticks, gastrointestinal nematodes and Eimeria spp. in Nellore cattle. Vet Parasitol. 2015;210(3-4):224–34. https://doi.org/10.1016/j.vetpar.2015.03.017.

    Article  CAS  PubMed  Google Scholar 

  • Peek HW, Landman WJM. Resistance to anticoccidial drugs of Dutch avian Eimeria spp. field isolates originating from 1996, 1999 and 2001. Avian Pathol. 2003;32:391–401.

    Article  CAS  PubMed  Google Scholar 

  • Peek HW, Landman WJ. Coccidiosis in poultry: anticoccidial products, vaccines and other prevention strategies. Vet Quart. 2011;31(3):143–61. https://doi.org/10.1080/01652176.2011.605247.

    Article  CAS  Google Scholar 

  • Pellerdy LP. Coccidia and Coccidiosis. 2nd ed. Berlin and Hamburg: Verlag Paul Parey; 1974. p. 434–45.

    Google Scholar 

  • Pérez-Fonseca A, Alcala-Canto Y, Salem AZ, Alberti-Navarro AB. Anticoccidial efficacy of naringenin and a grapefruit peel extract in growing lambs naturally-infected with Eimeria spp. Vet Parasitol. 2016;232:58–65. https://doi.org/10.1016/j.vetpar.2016.11.009.

    Article  CAS  PubMed  Google Scholar 

  • Permin A, Esmann JB, Hoj CH, Hove T, Mukaratirwa S. Ecto-, endo- and haemoparasites in free-range chickens in the Goromonzi District in Zimbabwe. Prev Vet Med. 2002;54:213–24.

    Article  CAS  PubMed  Google Scholar 

  • Persson L, Borg K, Falt H. On the occurrence of Endoparasites in eider ducks in Sweden. Viltrevy. 1974;9:1–24.

    Google Scholar 

  • Petrone VM, Constantino CF, Pradal-Roa P. Identification and quantification of granulocytes in caecal mucosa and submucosa of chickens experimentally infected with Eimeria tenella and Salmonella enteritidis. Br Poult Sci. 2002;43(5 Suppl):653–61.

    Article  CAS  PubMed  Google Scholar 

  • Pfister F, Wolff K. Incidence of endoparasites in swine bred under “specific-pathogen-free” (“SPF”) and conventional conditions. Schweiz Arch Tierheilkd. 1975;117(10):585–95.

    CAS  PubMed  Google Scholar 

  • Pinard-Van Der Laan MH, Monvoisin JL, Pery P, Hamet N, Thomas M. Comparison of outbred lines of chickens for resistance to experimental infection with coccidiosis (Eimeria tenella). Poultry Sci. 1998;77(2):185–91.

    Article  CAS  Google Scholar 

  • Radostits OM, Stockdale PHG. A brief review of bovine coccidiosis in western Canada. Can Vet J. 1980;21(8):227–30.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Reeg KJ, Gauly M, Bauer C, Mertens C, Erhardt G, Zahner H. Coccidial infections in housed lambs: oocyst excretion, antibody levels and genetic influences on the infection. Vet Parasitol. 2005;127(3-4):209–19.

    Article  PubMed  Google Scholar 

  • Riley D, Fernando MA. Eimeria maxima (Apicomplexa): A comparison of sporozoite transport in naive and immune chickens. J Parasitol. 1988;74(1):103.

    Article  CAS  PubMed  Google Scholar 

  • Roberts WL, Hammond DM. Ultrastructural and cytologic studies of the sporozoites of four Eimeria species. J Protozool. 1970;17(1):76–86.

    Article  CAS  PubMed  Google Scholar 

  • Rojas M, Manchego A, Rocha CB, Fornells LA, Silva RC, Mendes GS, Dias HG, Sandoval N, Pezo D, Santos N. Outbreak of diarrhea among preweaning alpacas (Vicugna pacos) in the southern Peruvian highland. J Infect Dev Ctries. 2016;10(3):269–74. https://doi.org/10.3855/jidc.7398.

    Article  PubMed  Google Scholar 

  • Rose ME. Immunity to Eimeria infections. Vet Immunol Immunopathol. 1987;17(1-4):333–43.

    Article  CAS  PubMed  Google Scholar 

  • Rose ME, Hesketh P. Immunity to coccidiosis: stages of the life-cycle of Eimeria maxima which induce, and are affected by, the response of the host. Parasitology. 1976;73(1):25–57.

    Article  CAS  PubMed  Google Scholar 

  • Rothwell L, Young JR, Zoorob R, Whittaker CA, Hesketh P, Archer A, Smith AL, Kaiser P. Cloning and characterization of chicken IL-10 and its role in the immune response to Eimeria maxima. J Immunol. 2004;173(4):2675–82.

    Article  CAS  PubMed  Google Scholar 

  • Ruiz A, Guedes AC, Muñoz MC, Molina JM, Hermosilla C, Martín S, Hernández YI, Hernández A, Pérez D, Matos L, López AM, Taubert A. Control strategies using diclazuril against coccidiosis in goat kids. Parasitol Res. 2012;110(6):2131–6. https://doi.org/10.1007/s00436-011-2746-0.

    Article  PubMed  Google Scholar 

  • Ruiz A, Muñoz MC, Molina JM, Hermosilla C, Andrada M, Lara P, Bordón E, Pérez D, López AM, Matos L, Guedes AC, Falcón S, Falcón Y, Martín S, Taubert A. Immunization with Eimeria ninakohlyakimovae-live attenuated oocysts protect goat kids from clinical coccidiosis. Vet Parasitol. 2014;199(1-2):8–17. https://doi.org/10.1016/j.vetpar.2013.09.032.

    Article  CAS  PubMed  Google Scholar 

  • Ryley JF, Millard BJ, Long PL. Further studies on the life cycle of Eimeria brunetti Levine 1942. Z Parasitenkd. 1972;40(1):35–48.

    Article  CAS  PubMed  Google Scholar 

  • Salisch H, Erhorn I, Behr KP, Siegmann O. Subclinical coccidiosis in broilers and pullets. Dtsch Tierärztl Wochenschr. 1989;96:493–6.

    CAS  PubMed  Google Scholar 

  • Samuelson J, Bushkin GG, Chatterjee A, Robbins PW. Strategies to discover the structural components of cyst and oocyst walls. Eukaryot Cell. 2013;12(12):1578–87. https://doi.org/10.1128/EC.00213-13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schneider J, Haass K. Occurrence of cecum (Eimeria tenella) coccidiosis in flocks of laying hens. Berl Münch Tierärztl Wochenschr. 1967;80(6):111–4.

    CAS  PubMed  Google Scholar 

  • Schnieder T. In: Schnieder T, editor. Veterinaermedizinische Parasitologie. 6th ed. Berlin: Paul Parey Verlag; 2006.

    Google Scholar 

  • Scholtyseck E, Hammond DM. Electron microscope studies of macrogametes and fertilization in Eimeria bovis. Z Parasitenkd. 1970;34(4):310–8.

    Article  CAS  PubMed  Google Scholar 

  • Schreiner LS. Field testing of the efficacy of additives based on essential oils to the milk replacer and litter treatment to control goat eimeriosis. Thesis. 2014. http://www.qucosa.de/recherche/frontdoor/?tx_slubopus4frontend%5bid%5d=urn:nbn:de:bsz:15-qucosa-144699.

  • Schrey CF, Abbott TA, Stewart VA, Marquardt WC. Coccidia of the llama, Lama glama, in Colorado and Wyoming. Vet Parasitol. 1991;40(1-2):21–8.

    Article  CAS  PubMed  Google Scholar 

  • Schwarz RS, Jenkins MC, Klopp S, Miska KB. Genomic analysis of Eimeria spp. populations in relation to performance levels of broiler chicken farms in Arkansas and North Carolina. J Parasitol. 2009;95(4):871–80. https://doi.org/10.1645/GE-1898.1.

    Article  CAS  PubMed  Google Scholar 

  • Seemann E, Kurth T, Entzeroth R. Insight into the ultrastructural organisation of sporulated oocysts of Eimeria nieschulzi (Coccidia, Apicomplexa). Parasitol Res. 2012;111(5):2143–7. https://doi.org/10.1007/s00436-012-3066-8.

    Article  PubMed  Google Scholar 

  • Sercy O, Nie K, Pascalon A, Fort G, Yvoré P. Receptivity and susceptibility of the domestic duck (Anas platyrhynchos), the Muscovy duck (Cairina moschata), and their hybrid, the mule duck, to an experimental infection by Eimeria mulardi. Avian Dis. 1996;40(1):23–7.

    Article  CAS  PubMed  Google Scholar 

  • Shahiduzzaman M, Dyachenko V, Keidel J, Schmäschke R, Daugschies A. Combination of cell culture and quantitative PCR (cc-qPCR) to assess disinfectants efficacy on Cryptosporidium oocysts under standardized conditions. Vet Parasitol. 2010;167(1):43–9. https://doi.org/10.1016/j.vetpar.2009.09.042.

    Article  CAS  PubMed  Google Scholar 

  • Shi T, Tao G, Bao G, Suo J, Hao L, Fu Y, Suo X. Stable transfection of Eimeria intestinalis and investigation of its life cycle, reproduction and immunogenicity. Front Microbiol. 2016;7:807. https://doi.org/10.3389/fmicb.2016.00807.

    Article  PubMed  PubMed Central  Google Scholar 

  • Shirley MW, Jeffers TK, Long PL. Studies to determine the taxonomic status of Eimeria mitis, Tyzzer 1929 and E. mivati, Edgar and Seibold 1964. Parasitology. 1983;87:185–98.

    Article  PubMed  Google Scholar 

  • Shirley MW, Smith AL, Tomley FM. The biology of avian Eimeria with an emphasis on their control by vaccination. Adv Parasitol. 2005;60:285–330.

    Article  PubMed  Google Scholar 

  • Shirzad MR, Seifi S, Gheisari HR, Hachesoo BA, Habibi H, Bujmehrani H. Prevalence and risk factors for subclinical coccidiosis in broiler chicken farms in Mazandaran province, Iran. Trop Anim Health Prod. 2011;43(8):1601–4. https://doi.org/10.1007/s11250-011-9876-3.

    Article  PubMed  Google Scholar 

  • Sibert GJ, Speer CA. Fine structure of zygotes and oocysts of Eimeria nieschulzi. J Protozool. 1980;27(4):374–9.

    Article  CAS  PubMed  Google Scholar 

  • Silva LM, Vila-Viçosa MJ, Cortes HC, Taubert A, Hermosilla C. Suitable in vitro Eimeria arloingi macromeront formation in host endothelial cells and modulation of adhesion molecule, cytokine and chemokine gene transcription. Parasitol Res. 2015;114(1):113–24. https://doi.org/10.1007/s00436-014-4166-4.

    Article  PubMed  Google Scholar 

  • Skírnisson K. Mortality associated with renal and intestinal coccidiosis in juvenile eiders in Iceland. Parassitologia. 1997;39(4):325–30.

    PubMed  Google Scholar 

  • Sommer C. Quantitative characterization, classification and reconstruction of oocyst shapes of Eimeria species from cattle. Parasitology. 1998;116(Pt 1):21–8.

    Article  PubMed  Google Scholar 

  • Stockdale PH. The pathogenesis of the lesions produced by Eimeria zuernii in calves. Can J Comp Med. 1977;41(3):338–44.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Stockdale PH, Sheard A, Tiffin GB. Resistance to Eimeria bovis produced after chemotherapy of experimental infections in calves. Vet Parasitol. 1982;9(3-4):171–7.

    Article  CAS  PubMed  Google Scholar 

  • Stotish RL, Wang CC, Meyenhofer M. Structure and composition of the oocyst wall of Eimeria tenella. J Parasitol. 1978;64(6):1074–81.

    Article  CAS  PubMed  Google Scholar 

  • Stromberg BE, Schlotthauer JC, Hamann KJ, Saatara Oz H, Bemrick WJ. Experimental bovine coccidiosis: control with monensin. Vet Parasitol. 1986;22(1-2):135–40.

    Article  CAS  PubMed  Google Scholar 

  • Sun XM, Pang W, Jia T, Yan WC, He G, Hao LL, Bentué M, Suo X. Prevalence of Eimeria species in broilers with subclinical signs from fifty farms. Avian Dis. 2009;53(2):301–5.

    Article  CAS  PubMed  Google Scholar 

  • Supperer R. Die Bedeutung der Sauen und Eber für die Verparasitierung der Schweinebestände. Wien Tierärztl Monatsschr. 1961;48:201–10.

    Google Scholar 

  • Swaggerty CL, Genovese KJ, He H, Duke SE, Pevzner IY, Kogut MH. Broiler breeders with an efficient innate immune response are more resistant to Eimeria tenella. Poultry Sci. 2011;90(5):1014–9. https://doi.org/10.3382/ps.2010-01246.

    Article  CAS  Google Scholar 

  • Szczepaniak KO, Tomczuk K, Lojszczyk-Szczepaniak A, Lopuszynski W. Reclassification of Eimeriapogonae Walden (2009) as Choleoeimeria pogonae comb. nov. (Apicomplexa: Eimeriidae). Parasitol Res. 2016;115(2):681–5.

    Article  PubMed  Google Scholar 

  • Taylor MA, Catchpole J. Review article: coccidiosis of domestic ruminants. Appl Parasitol. 1994;35(2):73–86.

    CAS  PubMed  Google Scholar 

  • Thekisoe MM, Mbati PA, Bisschop SP. Diseases of free-ranging chickens in the Qwa-Qwa District of the northeastern free state province of South Africa. J S Afr Vet Assoc. 2003;74:14–6.

    Article  CAS  PubMed  Google Scholar 

  • Tomley FM, Bumstead JM, Billington KJ, Dunn PP. Molecular cloning and characterization of a novel acidic microneme protein (Etmic-2) from the apicomplexan protozoan parasite, Eimeria tenella. Mol Biochem Parasitol. 1996;79(2):195–206.

    Article  CAS  PubMed  Google Scholar 

  • Toulah FH. Effect of aflatoxin on the coccidial infection in broilers. J Egypt Soc Parasitol. 2007;37:785–92.

    PubMed  Google Scholar 

  • Trees AJ, Karim MJ, McKellar SB, Carter SD. Eimeria tenella: local antibodies and interactions with the sporozoite surface. J Protozool. 1989;36(4):326–33.

    Article  CAS  PubMed  Google Scholar 

  • Van Immerseel F, De Buck J, Pasmans F, Huyghebaert G, Haesebrouck F, Ducatelle R. Clostridium perfringens in poultry: an emerging threat for animal and public health. Avian Pathol. 2004;33(6):537–49.

    Article  PubMed  Google Scholar 

  • Venkateswara Rao P, Raman M, Gomathinayagam S. Sporulation dynamics of poultry Eimeria oocysts in Chennai. J Parasit Dis. 2015;39(4):689–92. https://doi.org/10.1007/s12639-013-0403-5.

    Article  CAS  PubMed  Google Scholar 

  • Vercruysse J. Efficacy of toltrazuril and clazuril against experimental infections with Eimeria labbeana and E. columbarum in racing pigeons. Avian Dis. 1990;34(1):73–9.

    Article  CAS  PubMed  Google Scholar 

  • Vetterling JM. Coccidia (protozoa: Eimeriidae) of swine. J Parasitol. 1965;51(6):897–912.

    Article  CAS  PubMed  Google Scholar 

  • Vítovec J, Koudela B, Stĕrba J. Pathology and pathogenicity of Eimeria scabra (Henry, 1931) in experimentally infected pigs. Folia Parasitol (Praha). 1987;34(4):299–304.

    Google Scholar 

  • de Vos AJ. Studies on the host range of Eimeria chinchillae de Vos & van der Westhuizen, 1968. Onderstepoort J Vet Res. 1970;37(1):29–36.

    PubMed  Google Scholar 

  • Vrba V, Pakandl M. Coccidia of turkey: from isolation, characterisation and comparison to molecular phylogeny and molecular diagnostics. Int J Parasitol. 2014;44(13):985–1000. https://doi.org/10.1016/j.ijpara.2014.06.004.

    Article  CAS  PubMed  Google Scholar 

  • Vrba V, Pakandl M. Host specificity of turkey and chicken Eimeria: controlled cross-transmission studies and a phylogenetic view. Vet Parasitol. 2015;208(3-4):118–24. https://doi.org/10.1016/j.vetpar.2015.01.017.

    Article  PubMed  Google Scholar 

  • Vrba V, Poplstein M, Pakandl M. The discovery of the two types of small subunit ribosomal RNA gene in Eimeria mitis contests the existence of E. mivati as an independent species. Vet Parasitol. 2011;183(1-2):47–53. https://doi.org/10.1016/j.vetpar.2011.06.020.

    Article  CAS  PubMed  Google Scholar 

  • Wallach M. Role of antibody in immunity and control of chicken coccidiosis. Trends Parasitol. 2010;26(8):382–7. https://doi.org/10.1016/j.pt.2010.04.004.

    Article  PubMed  Google Scholar 

  • Wallach MG, Ashash U, Michael A, Smith NC. Field application of a subunit vaccine against an enteric protozoan disease. PLoS One. 2008;3(12):e3948. https://doi.org/10.1371/journal.pone.0003948.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Watkins KL, Bafundo KW, Donovan DJ. Anticoccidial effect of monensin against Eimeria mitis and Eimeria dispersa. Poul Sci. 1990;69(6):1009–11.

    Article  CAS  Google Scholar 

  • Wiedmer S, Stange J, Kurth T, Bleiss W, Entzeroth R, Kurth M. New insights into the excystation process and oocyst morphology of rodent Eimeria species. Protist. 2011;162(4):668–78. https://doi.org/10.1016/j.protis.2011.03.001.

    Article  PubMed  Google Scholar 

  • Williams RB. Laboratory tests of phenolic disinfectants as oocysticides against the chicken coccidium Eimeria tenella. Vet Rec. 1997;141(17):447–8.

    Article  CAS  PubMed  Google Scholar 

  • Williams RB. A compartmentalised model for the estimation of the cost of coccidiosis to the world’s chicken production industry. Int J Parasitol. 1999;29:1209–29.

    Article  CAS  PubMed  Google Scholar 

  • Witcombe DM, Smith NC. Strategies for anti-coccidial prophylaxis. Parasitology. 2014;141(11):1379–89. https://doi.org/10.1017/S0031182014000195.

    Article  CAS  PubMed  Google Scholar 

  • Yun CH, Lillehoj HS, Lillehoj EP. Intestinal immune responses to coccidiosis. Dev Comp Immunol. 2000;24(2-3):303–24.

    Article  CAS  PubMed  Google Scholar 

  • Yvoré P, Esnault A, Naciri M. La coccidiose caprine: Effect de contaminations mono ou multispécifiques. Rec Med Vet. 1985;161(4):347–51.

    Google Scholar 

  • Zhu JJ, Lillehoj HS, Allen PC, Van Tassell CP, Sonstegard TS, Cheng HH, Pollock D, Sadjadi M, Min W, Emara MG. Mapping quantitative trait loci associated with resistance to coccidiosis and growth. Poul Sci. 2003;82(1):9–16.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Berit Bangoura .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Bangoura, B., Daugschies, A. (2018). Eimeria . In: Florin-Christensen, M., Schnittger, L. (eds) Parasitic Protozoa of Farm Animals and Pets. Springer, Cham. https://doi.org/10.1007/978-3-319-70132-5_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-70132-5_3

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-70131-8

  • Online ISBN: 978-3-319-70132-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics