The Genetics of Triple-Negative Breast Cancer
With the advent of next generation sequencing, understanding genetic susceptibility to triple-negative breast cancer (TNBC) can lead to the identification, screening, and management of at-risk individuals and improved outcomes for those affected with this disease. The most commonly involved cancer susceptibility genes in TNBC are BRCA1 and BRCA2. Intense screening strategies have proven to identify affected cases, and risk-reducing surgical procedures have been shown to decrease the likelihood of developing cancer. Treatment of advanced TNBC remains a challenge. More emphasis should be placed on defining the genetic risk factors of TNBC which can ultimately lead to comprehensive efforts focused on cancer risk assessment and prevention.
KeywordsBreast cancer Germline hereditary mutations Inherited susceptibility BRCA1 BRCA2
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