Abstract
The Gram-negative bacterium Helicobacter pylori is predominantly known for its pathogenic role inducing peptic ulcer disease and gastric cancer. However, a considerable number of reports have linked H. pylori infection with the development of as well as protection from extra-gastrointestinal immunological disorders. Thus, recent epidemiological and experimental studies suggest that chronic infection with H. pylori might be beneficial for the host by conferring protection against allergic and chronic autoimmune diseases. In this chapter, we focus on the proposed beneficial role of H. pylori on atopic diseases, specifically asthma. We summarize the epidemiological data that support or refute a possible inverse correlation of H. pylori infection with atopic diseases. Experimental mouse studies show that asthma fails to develop in the presence of H. pylori. We examined and discussed involved bacterial factors and proposed mechanisms for this phenomenon. Mechanistically, the proposed mechanism involved in asthma protection is the particular property of H. pylori to induce regulatory T-cells (Tregs) with highly suppressive activity. These cells not only allow the bacterium to persist for decades in infected individuals but at the same time also work outside the stomach and confer protection against several diseases such as asthma and auto-inflammatory diseases.
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Abdallah TM, Mohammed HB, Mohammed MH, Ali AAA (2014 Apr) Sero-prevalence and factors associated with Helicobacter pylori infection in Eastern Sudan. Asian Pac J Trop Dis 4(2):115–119. https://doi.org/10.1016/S2222-1808(14)60326-1
Abebaw W, Kibret M, Abera B (2014) Prevalence and risk factors of H. pylori from dyspeptic patients in northwest Ethiopia: a hospital based cross-sectional study. Asian Pac J Cancer Prev 15(11):4459–4463
Agreus L, Hellstrom PM, Talley NJ, Wallner B, Forsberg A, Vieth M, Veits L, Bjorkegren K, Engstrand L, Andreasson A (2016) Towards a healthy stomach? Helicobacter pylori prevalence has dramatically decreased over 23 years in adults in a Swedish community. United Eur Gastroenterol J 4(5):686–696. https://doi.org/10.1177/2050640615623369
Aguemon BD, Struelens MJ, Massougbodji A, Ouendo EM (2005) Prevalence and risk-factors for Helicobacter pylori infection in urban and rural Beninese populations. Clin Microbiol Infect 11(8):611–617. https://doi.org/10.1111/j.1469-0691.2005.01189.x
Ahmad MM, Rahman M, Rumi AK, Islam S, Huq F, Chowdhury MF, Jinnah F, Morshed MG, Hassan MS, Khan AK, Hasan M (1997) Prevalence of Helicobacter pylori in asymptomatic population—a pilot serological study in Bangladesh. J Epidemiol 7(4):251–254
Akinbami LJ, Schoendorf KC (2002) Trends in childhood asthma: prevalence, health care utilization, and mortality. Pediatrics 110(2 Pt 1):315–322
Akinbami LJ, Moorman JE, Bailey C, Zahran HS, King M, Johnson CA, Liu X (2012) Trends in asthma prevalence, health care use, and mortality in the United States, 2001–2010. NCHS Data Brief 94:1–8
Al-Balushi MS, Al-Busaidi JZ, Al-Daihani MS, Shafeeq MO, Hasson SS (2013) Sero-prevalence of Helicobacter pylori infection among asymptomatic healthy Omani blood donors. Asian Pac J Trop Dis 3(2):146–149. https://doi.org/10.1016/S2222-1808(13)60059-6
Amberbir A, Medhin G, Erku W, Alem A, Simms R, Robinson K, Fogarty A, Britton J, Venn A, Davey G (2011) Effects of Helicobacter pylori, geohelminth infection and selected commensal bacteria on the risk of allergic disease and sensitization in 3-year-old Ethiopian children. Clin Exp Allergy 41(10):1422–1430. https://doi.org/10.1111/j.1365-2222.2011.03831.x
Amedei A, Cappon A, Codolo G, Cabrelle A, Polenghi A, Benagiano M, Tasca E, Azzurri A, D’Elios MM, Del Prete G, de Bernard M (2006) The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses. J Clin Investig 116(4):1092–1101. https://doi.org/10.1172/JCI27177
Andersen LP, Rosenstock SJ, Bonnevie O, Jorgensen T (1996) Seroprevalence of immunoglobulin G, M, and A antibodies to Helicobacter pylori in an unselected Danish population. Am J Epidemiol 143(11):1157–1164
Andoulo FA, Noah DN, Tagni-Sartre M, Ndam EC, Blackett KN (2013) Epidemiology of infection Helicobacter pylori in Yaounde: specificity of the African enigma. Pan Afr Med J 16:115. https://doi.org/10.11604/pamj.2013.16.115.3007
Annagur A, Kendirli SG, Yilmaz M, Altintas DU, Inal A (2007) Is there any relationship between asthma and asthma attack in children and atypical bacterial infections; Chlamydia pneumoniae, Mycoplasma pneumoniae and Helicobacter pylori. J Trop Pediatr 53(5):313–318. https://doi.org/10.1093/tropej/fmm040
Archampong TN, Asmah RH, Wiredu EK, Gyasi RK, Nkrumah KN, Rajakumar K (2015) Epidemiology of Helicobacter pylori infection in dyspeptic Ghanaian patients. Pan Afr Med J 20:178. 10.11604/pamj.2015.20.178.5024
Arnold IC, Dehzad N, Reuter S, Martin H, Becher B, Taube C, Muller A (2011a) Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. J Clin Investig 121(8):3088–3093. https://doi.org/10.1172/JCI45041
Arnold IC, Lee JY, Amieva MR, Roers A, Flavell RA, Sparwasser T, Muller A (2011b) Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia. Gastroenterology 140(1):199–209. https://doi.org/10.1053/j.gastro.2010.06.047
Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK, Williams H, Group IPTS (2006) Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicountry cross-sectional surveys. Lancet 368(9537):733–743. https://doi.org/10.1016/S0140-6736(06)69283-0
Asrat D, Nilsson I, Mengistu Y, Ashenafi S, Ayenew K, Al-Soud WA, Wadstrom T, Kassa E (2004) Prevalence of Helicobacter pylori infection among adult dyspeptic patients in Ethiopia. Ann Trop Med Parasitol 98(2):181–189. https://doi.org/10.1179/000349804225003190
Ategbo S, Rogombe SMO, Ngoungou E, Midili T, Moussavou A (2013) Épidémiologie de l’infection à Helicobacter pylori chez l’enfant de 6 mois à 7 ans à Libreville, Gabon. Clin Mother Child Health 10
Austin JB, Kaur B, Anderson HR, Burr M, Harkins LS, Strachan DP, Warner JO (1999) Hay fever, eczema, and wheeze: a nationwide UK study (ISAAC, international study of asthma and allergies in childhood). Arch Dis Child 81(3):225–230
Ayana SM, Swai B, Maro VP, Kibiki GS (2014) Upper gastrointestinal endoscopic findings and prevalence of Helicobacter pylori infection among adult patients with dyspepsia in northern Tanzania. Tanzan J Health Res 16(1):16–22
Baccioglu A, Kalpaklioglu F, Guliter S, Yakaryilmaz F (2008) Helicobacter pylori in allergic inflammation—fact or fiction? Allergol Immunopathol 36(2):85–89
Bach JF (2002) The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 347(12):911–920. https://doi.org/10.1056/NEJMra020100
Bani-Hani KE, Shatnawi NJ, El Qaderi S, Khader YS, Bani-Hani BK (2006) Prevalence and risk factors of Helicobacter pylori infection in healthy schoolchildren. Chin J Dig Dis 7(1):55–60. https://doi.org/10.1111/j.1443-9573.2006.00245.x
Begue RE, Gonzales JL, Correa-Gracian H, Tang SC (1998) Dietary risk factors associated with the transmission of Helicobacter pylori in Lima, Peru. Am J Trop Med Hyg 59(4):637–640
Benberin V, Bektayeva R, Karabayeva R, Lebedev A, Akemeyeva K, Paloheimo L, Syrjanen K (2013) Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers. Anticancer Res 33(10):4595–4602
Bloomfield SF, Stanwell-Smith R, Crevel RW, Pickup J (2006) Too clean, or not too clean: the hygiene hypothesis and home hygiene. Clin Exp Allergy 36(4):402–425. https://doi.org/10.1111/j.1365-2222.2006.02463.x
Bodner C, Anderson WJ, Reid TS, Godden DJ (2000) Childhood exposure to infection and risk of adult onset wheeze and atopy. Thorax 55(5):383–387
Breckan RK, Paulssen EJ, Asfeldt AM, Kvamme JM, Straume B, Florholmen J (2016) The all-age prevalence of Helicobacter pylori Infection and potential transmission routes. A population-based study. Helicobacter 21(6):586–595. https://doi.org/10.1111/hel.12316
Cam S, Ertem D, Bahceciler N, Akkoc T, Barlan I, Pehlivanoglu E (2009) The interaction between Helicobacter pylori and atopy: does inverse association really exist? Helicobacter 14(1):1–8. https://doi.org/10.1111/j.1523-5378.2009.00660.x
Canuckguy (2006) BlankMap-World6.svg. https://de.wikipedia.org/wiki/Datei:BlankMap-World6.svg#file
Carrilho C, Modcoicar P, Cunha L, Ismail M, Guisseve A, Lorenzoni C, Fernandes F, Peleteiro B, Almeida R, Figueiredo C, David L, Lunet N (2009) Prevalence of Helicobacter pylori infection, chronic gastritis, and intestinal metaplasia in Mozambican dyspeptic patients. Virchows Arch 454(2):153–160. https://doi.org/10.1007/s00428-008-0713-7
Carter FP, Frankson T, Pintard J, Edgecombe B (2011) Seroprevalence of Helicobacter pylori infection in adults in the Bahamas. West Indian Med J 60(6):662–665
Castano-Rodriguez N, Kaakoush NO, Lee WS, Mitchell HM (2015) Dual role of Helicobacter and Campylobacter species in IBD: a systematic review and meta-analysis. Gut. https://doi.org/10.1136/gutjnl-2015-310545
Castro-Giner F, Kauffmann F, de Cid R, Kogevinas M (2006) Gene-environment interactions in asthma. Occup Environ Med 63(11):776–786, 761. https://doi.org/10.1136/oem.2004.019216
Cataldo F, Simpore J, Greco P, Ilboudo D, Musumeci S (2004) Helicobacter pylori infection in Burkina Faso: an enigma within an enigma. Dig Liver Dis 36(9):589–593. https://doi.org/10.1016/j.dld.2004.05.005
Centers for Disease C, Prevention (2011) Vital signs: asthma prevalence, disease characteristics, and self-management education: United States, 2001–2009. MMWR Morb Mortal Wkly Rep 60(17):547–552
Chen Y, Blaser MJ (2007) Inverse associations of Helicobacter pylori with asthma and allergy. Arch Intern Med 167(8):821–827. https://doi.org/10.1001/archinte.167.8.821
Chen Y, Blaser MJ (2008) Helicobacter pylori colonization is inversely associated with childhood asthma. J Infect Dis 198(4):553–560. https://doi.org/10.1086/590158
Cheng H, Hu F, Zhang L, Yang G, Ma J, Hu J, Wang W, Gao W, Dong X (2009) Prevalence of Helicobacter pylori infection and identification of risk factors in rural and urban Beijing, China. Helicobacter 14(2):128–133. https://doi.org/10.1111/j.1523-5378.2009.00668.x
Chong VH, Lim KC, Rajendran N (2008) Prevalence of active Helicobacter pylori infection among patients referred for endoscopy in Brunei Darussalam. Singapore Med J 49(1):42–46
Codolo G, Mazzi P, Amedei A, Del Prete G, Berton G, D’Elios MM, de Bernard M (2008) The neutrophil-activating protein of Helicobacter pylori down-modulates Th2 inflammation in ovalbumin-induced allergic asthma. Cell Microbiol 10(11):2355–2363. https://doi.org/10.1111/j.1462-5822.2008.01217.x
Colmers-Gray IN, Vandermeer B, Greidanus RI, Kolber MR (2016) Helicobacter pylori status among patients undergoing gastroscopy in rural northern Alberta. Can Fam Physician 62(9):e547–e554
Coombes JL, Maloy KJ (2007) Control of intestinal homeostasis by regulatory T cells and dendritic cells. Semin Immunol 19(2):116–126. https://doi.org/10.1016/j.smim.2007.01.001
Coombes JL, Siddiqui KR, Arancibia-Carcamo CV, Hall J, Sun CM, Belkaid Y, Powrie F (2007) A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 204(8):1757–1764. https://doi.org/10.1084/jem.20070590
Corrado G, Luzzi I, Lucarelli S, Frediani T, Pacchiarotti C, Cavaliere M, Rea P, Cardi E (1998) Positive association between Helicobacter pylori infection and food allergy in children. Scand J Gastroenterol 33(11):1135–1139
Corrado G, Luzzi I, Pacchiarotti C, Lucarelli S, Frediani T, Cavaliere M, Rea P, Cardi E (2000) Helicobacter pylori seropositivity in children with atopic dermatitis as sole manifestation of food allergy. Pediatr Allergy Immunol 11(2):101–105
Cover TL (2016) Helicobacter pylori diversity and gastric cancer risk. mBio 7(1):e01869–e01815. https://doi.org/10.1128/mBio.01869-15
D’Elios MM, Codolo G, Amedei A, Mazzi P, Berton G, Zanotti G, Del Prete G, de Bernard M (2009) Helicobacter pylori, asthma and allergy. FEMS Immunol Med Microbiol 56(1):1–8. https://doi.org/10.1111/j.1574-695X.2009.00537.x
Darko R, Yawson AE, Osei V, Owusu-Ansah J, Aluze-Ele S (2015) Changing patterns of the prevalence of Helicobacter pylori among patients at a Corporate Hospital in Ghana. Ghana Med J 49(3):147–153
den Hollander WJ, Sonnenschein-van der Voort AM, Holster IL, de Jongste JC, Jaddoe VW, Hofman A, Perez-Perez GI, Moll HA, Blaser MJ, Duijts L, Kuipers EJ (2016) Helicobacter pylori in children with asthmatic conditions at school age, and their mothers. Aliment Pharmacol Ther. https://doi.org/10.1111/apt.13572
Denning TL, Wang YC, Patel SR, Williams IR, Pulendran B (2007) Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 8(10):1086–1094. https://doi.org/10.1038/ni1511
Destura RV, Labio ED, Barrett LJ, Alcantara CS, Gloria VI, Daez ML, Guerrant RL (2004) Laboratory diagnosis and susceptibility profile of Helicobacter pylori infection in the Philippines. Ann Clin Microbiol Antimicrob 3:25. https://doi.org/10.1186/1476-0711-3-25
Dhodapkar MV, Steinman RM, Krasovsky J, Munz C, Bhardwaj N (2001) Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 193(2):233–238
Diehl GE, Longman RS, Zhang JX, Breart B, Galan C, Cuesta A, Schwab SR, Littman DR (2013) Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells. Nature 494(7435):116–120. https://doi.org/10.1038/nature11809
Dinarello CA (1999) Interleukin-18. Methods 19(1):121–132. https://doi.org/10.1006/meth.1999.0837
Diomande MI, Flejou JF, Potet F, Dago-Akribi A, Ouattara D, Kadjo K, Niamkey E, Beaumel A, Gbe K, Beda BY (1991) Chronic gastritis and Helicobacter pylori infection on the Ivory Coast. A series of 277 symptomatic patients. Gastroenterol Clin Biol 15(10):711–716
Dorji D, Dendup T, Malaty HM, Wangchuk K, Yangzom D, Richter JM (2014) Epidemiology of Helicobacter pylori in Bhutan: the role of environment and Geographic location. Helicobacter 19(1):69–73. https://doi.org/10.1111/hel.12088
Edelson BT, Kc W, Juang R, Kohyama M, Benoit LA, Klekotka PA, Moon C, Albring JC, Ise W, Michael DG, Bhattacharya D, Stappenbeck TS, Holtzman MJ, Sung SS, Murphy TL, Hildner K, Murphy KM (2010) Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells. J Exp Med 207(4):823–836. https://doi.org/10.1084/jem.20091627
Edwards CN, Douglin CP, Prussia PR, Garriques SA, Levett PN (1997) Epidemiology of Helicobacter pylori infection in Barbados. West Indian Med J 46(1):3–7
Engler DB, Reuter S, van Wijck Y, Urban S, Kyburz A, Maxeiner J, Martin H, Yogev N, Waisman A, Gerhard M, Cover TL, Taube C, Muller A (2014) Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10. Proc Natl Acad Sci USA 111(32):11810–11815. https://doi.org/10.1073/pnas.1410579111
Fawcett JP, Barbezat GO, Poulton R, Milne BJ, Xia HH, Talley NJ (2005) Helicobacter pylori serology in a birth cohort of New Zealanders from age 11 to 26. World J Gastroenterol 11(21):3273–3276
Figura N, Perrone A, Gennari C, Orlandini G, Bianciardi L, Giannace R, Vaira D, Vagliasinti M, Rottoli P (1999a) Food allergy and Helicobacter pylori infection. Ital J Gastroenterol Hepatol 31(3):186–191
Figura N, Perrone A, Gennari C, Orlandini G, Giannace R, Lenzi C, Vagliasindi M, Bianciardi L, Rottoli P (1999b) CagA-positive Helicobacter pylori infection may increase the risk of food allergy development. J Physiol Pharmacol 50(5):827–831
Ford AC, Axon AT (2010) Epidemiology of Helicobacter pylori infection and public health implications. Helicobacter 15(Suppl 1):1–6. https://doi.org/10.1111/j.1523-5378.2010.00779.x
Fullerton D, Britton JR, Lewis SA, Pavord ID, McKeever TM, Fogarty AW (2009) Helicobacter pylori and lung function, asthma, atopy and allergic disease—a population-based cross-sectional study in adults. Int J Epidemiol 38(2):419–426. https://doi.org/10.1093/ije/dyn348
Girdaladze AM, Mosidze BA, Tsertsvadze TN, Shartava Ts K, Girdaladze SA (2008) The prevalence of Helicobacter pylori infection among the Georgian population. Georgian Med News 157:34–39
Goh KL, Chan WK, Shiota S, Yamaoka Y (2011) Epidemiology of Helicobacter pylori infection and public health implications. Helicobacter 16(Suppl 1):1–9. https://doi.org/10.1111/j.1523-5378.2011.00874.x
Gomez NA, Salvador A, Vargas PE, Zapatier JA, Alvarez J (2004) Seroprevalence of Helicobacter pylori among the child population of ecuador. Rev Gastroenterol Peru 24(3):230–233
Gonzalez-Rivera C, Algood HM, Radin JN, McClain MS, Cover TL (2012) The intermediate region of Helicobacter pylori VacA is a determinant of toxin potency in a Jurkat T cell assay. Infect Immun 80(8):2578–2588. https://doi.org/10.1128/IAI.00052-12
Goto Y, Syam AF, Darnindro N, Puspita Hapsari FC (2016) Risk factors for and prevalence of Helicobacter Pylori Infection among healthy inhabitants in Northern Jakarta, Indonesia. Asian Pac J Cancer Prev 17(9):4469–4475
Grad YH, Lipsitch M, Aiello AE (2012) Secular trends in Helicobacter pylori seroprevalence in adults in the United States: evidence for sustained race/ethnic disparities. Am J Epidemiol 175(1):54–59. https://doi.org/10.1093/aje/kwr288
Gubina AV, Tsaregorodtseva TM, Sokolova GN, Serova TI (2006) Chronic pancreatitis and anti-Helicobacter pylori antibodies. Exp Clin Gastroenterol 1:69–71
Gunaid AA, Hassan NA, Murray-Lyon I (2003) Prevalence and risk factors for Helicobacter pylori infection among Yemeni dyspeptic patients. Saudi Med J 24(5):512–517
Harris PR, Wright SW, Serrano C, Riera F, Duarte I, Torres J, Pena A, Rollan A, Viviani P, Guiraldes E, Schmitz JM, Lorenz RG, Novak L, Smythies LE, Smith PD (2008) Helicobacter pylori gastritis in children is associated with a regulatory T-cell response. Gastroenterology 134(2):491–499. https://doi.org/10.1053/j.gastro.2007.11.006
Herbarth O, Bauer M, Fritz GJ, Herbarth P, Rolle-Kampczyk U, Krumbiegel P, Richter M, Richter T (2007) Helicobacter pylori colonisation and eczema. J Epidemiol Commun Health 61(7):638–640. https://doi.org/10.1136/jech.2006.046706
Heuberger F, Pantoflickova D, Gassner M, Oneta C, Grehn M, Blum AL, Dorta G (2003) Helicobacter pylori infection in Swiss adolescents: prevalence and risk factors. Eur J Gastroenterol Hepatol 15(2):179–183
Hitzler I, Oertli M, Becher B, Agger EM, Muller A (2011) Dendritic cells prevent rather than promote immunity conferred by a helicobacter vaccine using a mycobacterial adjuvant. Gastroenterology 141(1):186–196, 196.e181. https://doi.org/10.1053/j.gastro.2011.04.009
Hitzler I, Sayi A, Kohler E, Engler DB, Koch KN, Hardt WD, Muller A (2012) Caspase-1 has both proinflammatory and regulatory properties in Helicobacter infections, which are differentially mediated by its substrates IL-1beta and IL-18. J Immunol 188(8):3594–3602. https://doi.org/10.4049/jimmunol.1103212
Hoang TT, Bengtsson C, Phung DC, Sorberg M, Granstrom M (2005) Seroprevalence of Helicobacter pylori infection in urban and rural Vietnam. Clin Diagn Lab Immunol 12(1):81–85. https://doi.org/10.1128/CDLI.12.1.81-85.2005
Holster IL, Vila AM, Caudri D, den Hoed CM, Perez-Perez GI, Blaser MJ, de Jongste JC, Kuipers EJ (2012) The impact of Helicobacter pylori on atopic disorders in childhood. Helicobacter 17(3):232–237. https://doi.org/10.1111/j.1523-5378.2012.00934.x
Hussain K, Letley DP, Greenaway AB, Kenefeck R, Winter JA, Tomlinson W, Rhead J, Staples E, Kaneko K, Atherton JC, Robinson K (2016) Helicobacter pylori-mediated protection from allergy is associated with IL-10-secreting peripheral blood regulatory T cells. Front Immunol 7:71. https://doi.org/10.3389/fimmu.2016.00071
Hussein NR, Robinson K, Atherton JC (2008) A study of age-specific Helicobacter pylori seropositivity rates in Iraq. Helicobacter 13(4):306–307. https://doi.org/10.1111/j.1523-5378.2008.00618.x
Imamura S, Sugimoto M, Kanemasa K, Sumida Y, Okanoue T, Yoshikawa T, Yamaoka Y (2010) Inverse association between Helicobacter pylori infection and allergic rhinitis in young Japanese. J Gastroenterol Hepatol 25(7):1244–1249. https://doi.org/10.1111/j.1440-1746.2010.06307.x
Inoue M (2016) Changing epidemiology of Helicobacter pylori in Japan. Gastric Cancer. https://doi.org/10.1007/s10120-016-0658-5
Iwasaki A, Kelsall BL (2001) Unique functions of CD11b+, CD8 alpha+, and double-negative Peyer’s patch dendritic cells. J Immunol 166(8):4884–4890
Jaber SM (2006) Helicobacter pylori seropositivity in children with chronic disease in Jeddah, Saudi Arabia. Saudi J Gastroenterol 12(1):21–26
Jaime F, Villagran A, Serrano C, Cerda J, Harris PR (2013) Frequency of Helicobacter pylori infection in 144 school age Chilean children. Rev Med Chil 141(10):1249–1254. https://doi.org/10.4067/s0034-98872013001000003
Janson C, Asbjornsdottir H, Birgisdottir A, Sigurjonsdottir RB, Gunnbjornsdottir M, Gislason D, Olafsson I, Cook E, Jogi R, Gislason T, Thjodleifsson B (2007) The effect of infectious burden on the prevalence of atopy and respiratory allergies in Iceland, Estonia, and Sweden. J Allergy Clin Immunol 120(3):673–679. https://doi.org/10.1016/j.jaci.2007.05.003
Jarvis D, Luczynska C, Chinn S, Burney P (2004) The association of hepatitis A and Helicobacter pylori with sensitization to common allergens, asthma and hay fever in a population of young British adults. Allergy 59(10):1063–1067. https://doi.org/10.1111/j.1398-9995.2004.00539.x
Jiang JX, Liu Q, Mao XY, Zhang HH, Zhang GX, Xu SF (2016) Downward trend in the prevalence of Helicobacter pylori infections and corresponding frequent upper gastrointestinal diseases profile changes in Southeastern China between 2003 and 2012. SpringerPlus 5(1):1601. https://doi.org/10.1186/s40064-016-3185-2
Jonaitis L, Kiudelis G, Kupcinskas L, Kupcinskas J (2013) Prevalence of helicobacter pylori among outpatient middle-aged patients in Lithuania and its relation to dyspeptic symptoms. Helicobacter 18:104
Jun ZJ, Lei Y, Shimizu Y, Dobashi K, Mori M (2005) Helicobacter pylori seroprevalence in patients with mild asthma. Tohoku J Exp Med 207(4):287–291
Kabisch R, Semper RP, Wustner S, Gerhard M, Mejias-Luque R (2016) Helicobacter pylori gamma-glutamyltranspeptidase induces tolerogenic human dendritic cells by activation of glutamate receptors. J Immunol 196(10):4246–4252. https://doi.org/10.4049/jimmunol.1501062
Kaebisch R, Mejias-Luque R, Prinz C, Gerhard M (2014) Helicobacter pylori cytotoxin-associated gene A impairs human dendritic cell maturation and function through IL-10-mediated activation of STAT3. J Immunol 192(1):316–323. https://doi.org/10.4049/jimmunol.1302476
Kao JY, Zhang M, Miller MJ, Mills JC, Wang B, Liu M, Eaton KA, Zou W, Berndt BE, Cole TS, Takeuchi T, Owyang SY, Luther J (2010) Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice. Gastroenterology 138(3):1046–1054. https://doi.org/10.1053/j.gastro.2009.11.043
Karimi A, Fakhimi-Derakhshan K, Imanzadeh F, Rezaei M, Cavoshzadeh Z, Maham S (2013) Helicobacter pylori infection and pediatric asthma. Iran J Microbiol 5(2):132–135
Khedmat H, Karbasi-Afshar R, Agah S, Taheri S (2013) Helicobacter pylori Infection in the general population: a middle Eastern perspective. Caspian J Intern Med 4(4):745–753
Kibru D, Gelaw B, Alemu A, Addis Z (2014) Helicobacter pylori infection and its association with anemia among adult dyspeptic patients attending Butajira Hospital, Ethiopia. BMC Infect Dis 14:656. https://doi.org/10.1186/s12879-014-0656-3
Kim JH, Kim HY, Kim NY, Kim SW, Kim JG, Kim JJ, Roe IH, Seo JK, Sim JG, Ahn H, Yoon BC, Lee SW, Lee YC, Chung IS, Jung HY, Hong WS, Choi KW (2001) Seroepidemiological study of Helicobacter pylori infection in asymptomatic people in South Korea. J Gastroenterol Hepatol 16(9):969–975
Kim JM, Kim JS, Yoo DY, Ko SH, Kim N, Kim H, Kim YJ (2011) Stimulation of dendritic cells with Helicobacter pylori vacuolating cytotoxin negatively regulates their maturation via the restoration of E2F1. Clin Exp Immunol 166(1):34–45. https://doi.org/10.1111/j.1365-2249.2011.04447.x
Kimang’a AN, Revathi G, Kariuki S, Sayed S, Devani S (2010) Helicobacter pylori: prevalence and antibiotic susceptibility among Kenyans. SAMJ 100:53–57
Kimura A, Kishimoto T (2010) IL-6: regulator of Treg/Th17 balance. Eur J Immunol 40(7):1830–1835. https://doi.org/10.1002/eji.201040391
Koch KN, Muller A (2015) Helicobacter pylori activates the TLR2/NLRP3/caspase-1/IL-18 axis to induce regulatory T-cells, establish persistent infection and promote tolerance to allergens. Gut Microbes 6(6):382–387. https://doi.org/10.1080/19490976.2015.1105427
Kolho KL, Haapaniemi A, Haahtela T, Rautelin H (2005) Helicobacter pylori and specific immunoglobulin E antibodies to food allergens in children. J Pediatr Gastroenterol Nutr 40(2):180–183
Konturek PC, Rienecker H, Hahn EG, Raithel M (2008) Helicobacter pylori as a protective factor against food allergy. Med Sci Monit 14(9):Cr452–Cr458
Kosunen TU, Hook-Nikanne J, Salomaa A, Sarna S, Aromaa A, Haahtela T (2002) Increase of allergen-specific immunoglobulin E antibodies from 1973 to 1994 in a Finnish population and a possible relationship to Helicobacter pylori infections. Clin Exp Allergy 32(3):373–378
Kretschmer K, Apostolou I, Hawiger D, Khazaie K, Nussenzweig MC, von Boehmer H (2005) Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol 6(12):1219–1227. https://doi.org/10.1038/ni1265
Kuzela L, Oltman M, Sutka J, Zacharova B, Nagy M (2012) Epidemiology of Helicobacter pylori infection in the Slovak Republic. Hepato-Gastroenterol 59(115):754–756. https://doi.org/10.5754/hge11457
Lai CK, Beasley R, Crane J, Foliaki S, Shah J, Weiland S, International Study of A, Allergies in Childhood Phase Three Study G (2009) Global variation in the prevalence and severity of asthma symptoms: phase three of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 64(6):476–483. https://doi.org/10.1136/thx.2008.106609
Leveque L, Deknuydt F, Bioley G, Old LJ, Matsuzaki J, Odunsi K, Ayyoub M, Valmori D (2009) Interleukin 2-mediated conversion of ovarian cancer-associated CD4+ regulatory T cells into proinflammatory interleukin 17-producing helper T cells. J Immunother 32(2):101–108. https://doi.org/10.1097/CJI.0b013e318195b59e
Li W, Minohara M, Su JJ, Matsuoka T, Osoegawa M, Ishizu T, Kira J (2007) Helicobacter pylori infection is a potential protective factor against conventional multiple sclerosis in the Japanese population. J Neuroimmunol 184(1-2):227–231. https://doi.org/10.1016/j.jneuroim.2006.12.010
Li Z, Zou D, Ma X, Chen J, Shi X, Gong Y, Man X, Gao L, Zhao Y, Wang R, Yan X, Dent J, Sung JJ, Wernersson B, Johansson S, Liu W, He J (2010) Epidemiology of peptic ulcer disease: endoscopic results of the systematic investigation of gastrointestinal disease in China. Am J Gastroenterol 105(12):2570–2577. https://doi.org/10.1038/ajg.2010.324
Lim JH, Kim N, Lim SH, Kwon JW, Shin CM, Chang YS, Kim JS, Jung HC, Cho SH (2016) Inverse relationship between Helicobacter pylori infection and asthma among adults younger than 40 years: a cross-sectional study. Medicine 95(8):e2609. https://doi.org/10.1097/MD.0000000000002609
Lindo JF, Lyn-Sue AE, Palmer CJ, Lee MG, Vogel P, Robinson RD (1999) Seroepidemiology of Helicobacter pylori infection in a Jamaican community. Trop Med Int Health 4(12):862–866
Linneberg A, Ostergaard C, Tvede M, Andersen LP, Nielsen NH, Madsen F, Frolund L, Dirksen A, Jorgensen T (2003) IgG antibodies against microorganisms and atopic disease in Danish adults: the Copenhagen Allergy Study. J Allergy Clin Immunol 111(4):847–853
Lionetti E, Leonardi S, Lanzafame A, Garozzo MT, Filippelli M, Tomarchio S, Ferrara V, Salpietro C, Pulvirenti A, Francavilla R, Catassi C (2014) Helicobacter pylori infection and atopic diseases: is there a relationship? A systematic review and meta-analysis. World J Gastroenterol 20(46):17635–17647. https://doi.org/10.3748/wjg.v20.i46.17635
Liu X, Fu G, Ji Z, Huang X, Ding C, Jiang H, Wang X, Du M, Wang T, Kang Q (2016) A recombinant DNA plasmid encoding the sIL-4R-NAP fusion protein suppress airway inflammation in an OVA-induced mouse model of asthma. Inflammation 39(4):1434–1440. https://doi.org/10.1007/s10753-016-0375-6
Lundgren A, Suri-Payer E, Enarsson K, Svennerholm AM, Lundin BS (2003) Helicobacter pylori-specific CD4+ CD25high regulatory T cells suppress memory T-cell responses to H. pylori in infected individuals. Infect Immun 71(4):1755–1762
Lundgren A, Stromberg E, Sjoling A, Lindholm C, Enarsson K, Edebo A, Johnsson E, Suri-Payer E, Larsson P, Rudin A, Svennerholm AM, Lundin BS (2005a) Mucosal FOXP3-expressing CD4+ CD25high regulatory T cells in Helicobacter pylori-infected patients. Infect Immun 73(1):523–531. https://doi.org/10.1128/IAI.73.1.523-531.2005
Lundgren A, Trollmo C, Edebo A, Svennerholm AM, Lundin BS (2005b) Helicobacter pylori-specific CD4+ T cells home to and accumulate in the human Helicobacter pylori-infected gastric mucosa. Infect Immun 73(9):5612–5619. https://doi.org/10.1128/IAI.73.9.5612-5619.2005
Luther J, Dave M, Higgins PD, Kao JY (2010) Association between Helicobacter pylori infection and inflammatory bowel disease: a meta-analysis and systematic review of the literature. Inflamm Bowel Dis 16(6):1077–1084. https://doi.org/10.1002/ibd.21116
Ly NP, Litonjua A, Gold DR, Celedon JC (2011) Gut microbiota, probiotics, and vitamin D: interrelated exposures influencing allergy, asthma, and obesity? J Allergy Clin Immunol 127(5):1087–1094; quiz 1095–1086. https://doi.org/10.1016/j.jaci.2011.02.015
Mailer RK, Joly AL, Liu S, Elias S, Tegner J, Andersson J (2015) IL-1beta promotes Th17 differentiation by inducing alternative splicing of FOXP3. Sci Rep 5:14674. https://doi.org/10.1038/srep14674
Maldonado RA, von Andrian UH (2010) How tolerogenic dendritic cells induce regulatory T cells. Adv Immunol 108:111–165. https://doi.org/10.1016/B978-0-12-380995-7.00004-5
Mannino DM, Homa DM, Akinbami LJ, Moorman JE, Gwynn C, Redd SC (2002) Surveillance for asthma—United States, 1980–1999. Morb Mortal Wkly Rep Surveill Summ 51(1):1–13
Matricardi PM, Rosmini F, Riondino S, Fortini M, Ferrigno L, Rapicetta M, Bonini S (2000) Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. BMJ 320(7232):412–417
Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL (2005) An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 122(1):107–118. https://doi.org/10.1016/j.cell.2005.05.007
McCune A, Lane A, Murray L, Harvey I, Nair P, Donovan J, Harvey R (2003) Reduced risk of atopic disorders in adults with Helicobacter pylori infection. Eur J Gastroenterol Hepatol 15(6):637–640. https://doi.org/10.1097/01.meg.0000059127.68845.57
McLaughlin NJ, McLaughlin DI, Lefcort H (2003) The influence of socio-economic factors on Helicobacter pylori infection rates of students in rural Zambia. Centr Afr J Med 49(3-4):38–41
McLoughlin RM, Mills KH (2011) Influence of gastrointestinal commensal bacteria on the immune responses that mediate allergy and asthma. J Allergy Clin Immunol 127(5):1097–1107; quiz 1108–1099. https://doi.org/10.1016/j.jaci.2011.02.012
Memon AA, Hussein NR, Miendje Deyi VY, Burette A, Atherton JC (2014) Vacuolating cytotoxin genotypes are strong markers of gastric cancer and duodenal ulcer-associated Helicobacter pylori strains: a matched case-control study. J Clin Microbiol 52(8):2984–2989. https://doi.org/10.1128/JCM.00551-14
Miftahussurur M, Tuda J, Suzuki R, Kido Y, Kawamoto F, Matsuda M, Tantular IS, Pusarawati S, Nasronudin, Harijanto PN, Yamaoka Y (2014) Extremely low Helicobacter pylori prevalence in North Sulawesi, Indonesia and identification of a Maori-tribe type strain: a cross sectional study. Gut Pathogens 6(1):42. https://doi.org/10.1186/s13099-014-0042-0
Miftahussurur M, Sharma RP, Shrestha PK, Maharjan RK, Shiota S, Uchida T, Sato H, Yamaoka Y (2015) Helicobacter pylori infection and gastric mucosal atrophy in two ethnic groups in Nepal. Asian Pac J Cancer Prev 16(17):7911–7916
Milman N, Byg KE, Andersen LP, Mulvad G, Pedersen HS, Bjerregaard P (2003) Indigenous Greenlanders have a higher sero-prevalence of IgG antibodies to Helicobacter pylori than Danes. Int J Circumpolar Health 62(1):54–60
Mishra S, Singh V, Rao GR, Dixit VK, Gulati AK, Nath G (2008) Prevalence of Helicobacter pylori in asymptomatic subjects—a nested PCR based study. Infect Genet Evol 8(6):815–819. https://doi.org/10.1016/j.meegid.2008.08.001
Muhammad JS, Zaidi SF, Sugiyama T (2012) Epidemiological ins and outs of helicobacter pylori: a review. JPMA J Pak Med Assoc 62(9):955–959
Myint T, Shiota S, Vilaichone RK, Ni N, Aye TT, Matsuda M, Tran TT, Uchida T, Mahachai V, Yamaoka Y (2015) Prevalence of Helicobacter pylori infection and atrophic gastritis in patients with dyspeptic symptoms in Myanmar. World J Gastroenterol 21(2):629–636. https://doi.org/10.3748/wjg.v21.i2.629
Nagy P, Johansson S, Molloy-Bland M (2016) Systematic review of time trends in the prevalence of Helicobacter pylori infection in China and the USA. Gut Pathogens 8:8. https://doi.org/10.1186/s13099-016-0091-7
Naja F, Kreiger N, Sullivan T (2007) Helicobacter pylori infection in Ontario: prevalence and risk factors. Can J Gastroenterol 21(8):501–506
Naous A, Al-Tannir M, Naja Z, Ziade F, El-Rajab M (2007) Fecoprevalence and determinants of Helicobacter pylori infection among asymptomatic children in Lebanon. Leban Med J 55(3):138–144
Newton R, Ziegler JL, Casabonne D, Carpenter L, Gold BD, Owens M, Beral V, Mbidde E, Parkin DM, Wabinga H, Mbulaiteye S, Jaffe H (2006) Helicobacter pylori and cancer among adults in Uganda. Infect Agents Cancer 1:5. https://doi.org/10.1186/1750-9378-1-5
Ntagirabiri R, Harerimana S, Makuraza F, Ndirahisha E, Kaze H, Moibeni A (2014) Helicobacter pylori au Burundi: première évaluation de la prévalence en endoscopie et de l’éradication. J Afr d’Hépato-Gastroentérol 8(4):217–222. https://doi.org/10.1007/s12157-014-0567-3
Oertli M, Muller A (2012) Helicobacter pylori targets dendritic cells to induce immune tolerance, promote persistence and confer protection against allergic asthma. Gut Microbes 3(6):566–571. https://doi.org/10.4161/gmic.21750
Oertli M, Sundquist M, Hitzler I, Engler DB, Arnold IC, Reuter S, Maxeiner J, Hansson M, Taube C, Quiding-Jarbrink M, Muller A (2012) DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protection. J Clin Investig 122(3):1082–1096. https://doi.org/10.1172/JCI61029
Oertli M, Noben M, Engler DB, Semper RP, Reuter S, Maxeiner J, Gerhard M, Taube C, Muller A (2013) Helicobacter pylori gamma-glutamyl transpeptidase and vacuolating cytotoxin promote gastric persistence and immune tolerance. Proc Natl Acad Sci USA 110(8):3047–3052. https://doi.org/10.1073/pnas.1211248110
Olivares A, Buadze M, Kutubidze T, Lobjanidze M, Labauri L, Kutubidze R, Chikviladze D, Zhvania M, Kharzeishvili O, Lomidze N, Perez-Perez GI (2006) Prevalence of Helicobacter pylori in Georgian patients with dyspepsia. Helicobacter 11(2):81–85. https://doi.org/10.1111/j.1523-5378.2006.00367.x
Onishi Y, Fehervari Z, Yamaguchi T, Sakaguchi S (2008) Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc Natl Acad Sci USA 105(29):10113–10118. https://doi.org/10.1073/pnas.0711106105
Ontsira Ngoyi EN, Atipo Ibara BI, Moyen R, Ahoui Apendi PC, Ibara JR, Obengui O, Ossibi Ibara RB, Nguimbi E, Niama RF, Ouamba JM, Yala F, Abena AA, Vadivelu J, Goh KL, Menard A, Benejat L, Sifre E, Lehours P, Megraud F (2015) Molecular detection of Helicobacter pylori and its antimicrobial resistance in Brazzaville, Congo. Helicobacter 20(4):316–320. https://doi.org/10.1111/hel.12204
Ortega JP, Espino A, Calvo BA, Verdugo P, Pruyas M, Nilsen E, Villarroel L, Padilla O, Riquelme A, Rollan A (2010) Helicobacter pylori infection in symptomatic patients with benign gastroduodenal diseases: analysis of 5.664 cases. Rev Med Chil 138(5):529–535. https://doi.org/10.4067/S0034-98872010000500001
Pearce N, Ait-Khaled N, Beasley R, Mallol J, Keil U, Mitchell E, Robertson C, Group IPTS (2007) Worldwide trends in the prevalence of asthma symptoms: phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax 62(9):758–766. https://doi.org/10.1136/thx.2006.070169
Pedrini MJ, Seewann A, Bennett KA, Wood AJ, James I, Burton J, Marshall BJ, Carroll WM, Kermode AG (2015) Helicobacter pylori infection as a protective factor against multiple sclerosis risk in females. J Neurol Neurosurg Psychiatry 86(6):603–607. https://doi.org/10.1136/jnnp-2014-309495
Pessi T, Virta M, Adjers K, Karjalainen J, Rautelin H, Kosunen TU, Hurme M (2005) Genetic and environmental factors in the immunopathogenesis of atopy: interaction of Helicobacter pylori infection and IL4 genetics. Int Arch Allergy Immunol 137(4):282–288. https://doi.org/10.1159/000086421
Prescott SL, Macaubas C, Holt BJ, Smallacombe TB, Loh R, Sly PD, Holt PG (1998) Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. J Immunol 160(10):4730–4737
Rad R, Dossumbekova A, Neu B, Lang R, Bauer S, Saur D, Gerhard M, Prinz C (2004) Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonisation during Helicobacter pylori infection. Gut 53(8):1082–1089. https://doi.org/10.1136/gut.2003.029736
Radon K, Windstetter D, Eckart J, Dressel H, Leitritz L, Reichert J, Schmid M, Praml G, Schosser M, von Mutius E, Nowak D (2004) Farming exposure in childhood, exposure to markers of infections and the development of atopy in rural subjects. Clin Exp Allergy 34(8):1178–1183. https://doi.org/10.1111/j.1365-2222.2004.02005.x
Reibman J, Marmor M, Filner J, Fernandez-Beros ME, Rogers L, Perez-Perez GI, Blaser MJ (2008) Asthma is inversely associated with Helicobacter pylori status in an urban population. PloS One 3(12):e4060. https://doi.org/10.1371/journal.pone.0004060
Rizzuti D, Ang M, Sokollik C, Wu T, Abdullah M, Greenfield L, Fattouh R, Reardon C, Tang M, Diao J, Schindler C, Cattral M, Jones NL (2015) Helicobacter pylori inhibits dendritic cell maturation via interleukin-10-mediated activation of the signal transducer and activator of transcription 3 pathway. J Innate Immun 7(2):199–211. https://doi.org/10.1159/000368232
Robinson K, Kenefeck R, Pidgeon EL, Shakib S, Patel S, Polson RJ, Zaitoun AM, Atherton JC (2008) Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T cell responses. Gut 57(10):1375–1385. https://doi.org/10.1136/gut.2007.137539
Roka K, Roubani A, Stefanaki K, Panayotou I, Roma E, Chouliaras G (2014) The prevalence of Helicobacter pylori gastritis in newly diagnosed children with inflammatory bowel disease. Helicobacter 19(5):400–405. https://doi.org/10.1111/hel.12141
Ronchetti R, Villa MP, Barreto M, Rota R, Pagani J, Martella S, Falasca C, Paggi B, Guglielmi F, Ciofetta G (2001) Is the increase in childhood asthma coming to an end? Findings from three surveys of schoolchildren in Rome, Italy. Eur Respir J 17(5):881–886
Russell SL, Gold MJ, Willing BP, Thorson L, McNagny KM, Finlay BB (2013) Perinatal antibiotic treatment affects murine microbiota, immune responses and allergic asthma. Gut Microbes 4(2):158–164. https://doi.org/10.4161/gmic.23567
Ryanna K, Stratigou V, Safinia N, Hawrylowicz C (2009) Regulatory T cells in bronchial asthma. Allergy 64(3):335–347. https://doi.org/10.1111/j.1398-9995.2009.01972.x
Sanchez Ceballos F, Taxonera Samso C, Garcia Alonso C, Alba Lopez C, Sainz de Los Terreros Soler L, Diaz-Rubio M (2007) Prevalence of Helicobacter pylori infection in the healthy population of Madrid (Spain). Rev Esp Enferm Dig 99(9):497–501
Sasaki T, Hirai I, Yamamoto Y (2009) Analysis of Helicobacter pylori infection in a healthy Panamanian population. Kansenshogaku Zasshi 83(2):127–132
Secka O, Antonio M, Berg DE, Tapgun M, Bottomley C, Thomas V, Walton R, Corrah T, Thomas JE, Adegbola RA (2011) Mixed infection with cagA positive and cagA negative strains of Helicobacter pylori lowers disease burden in the Gambia. PloS One 6(11):e27954. https://doi.org/10.1371/journal.pone.0027954
Seiskari T, Kondrashova A, Viskari H, Kaila M, Haapala AM, Aittoniemi J, Virta M, Hurme M, Uibo R, Knip M, Hyoty H (2007) Allergic sensitization and microbial load—a comparison between Finland and Russian Karelia. Clin Exp Immunol 148(1):47–52. https://doi.org/10.1111/j.1365-2249.2007.03333.x
Semper RP, Mejias-Luque R, Gross C, Anderl F, Muller A, Vieth M, Busch DH, Prazeres da Costa C, Ruland J, Gross O, Gerhard M (2014) Helicobacter pylori-induced IL-1beta secretion in innate immune cells is regulated by the NLRP3 inflammasome and requires the cag pathogenicity island. J Immunol 193(7):3566–3576. https://doi.org/10.4049/jimmunol.1400362
Serizawa T, Hirata Y, Hayakawa Y, Suzuki N, Sakitani K, Hikiba Y, Ihara S, Kinoshita H, Nakagawa H, Tateishi K, Koike K (2015) Gastric metaplasia induced by Helicobacter pylori is associated with enhanced SOX9 expression via Interleukin-1 signaling. Infect Immun 84(2):562–572. https://doi.org/10.1128/iai.01437-15
Shigematsu Y, Niwa T, Rehnberg E, Toyoda T, Yoshida S, Mori A, Wakabayashi M, Iwakura Y, Ichinose M, Kim YJ, Ushijima T (2013) Interleukin-1beta induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis. Cancer Lett 340(1):141–147. https://doi.org/10.1016/j.canlet.2013.07.034
Shiota S, Cruz M, Abreu JA, Mitsui T, Terao H, Disla M, Iwatani S, Nagashima H, Matsuda M, Uchida T, Tronilo L, Rodriguez E, Yamaoka Y (2014) Virulence genes of Helicobacter pylori in the Dominican Republic. J Med Microbiol 63(Pt 9):1189–1196. https://doi.org/10.1099/jmm.0.075275-0
Shiotani A, Miyanishi T, Kamada T, Haruma K (2008) Helicobacter pylori infection and allergic diseases: epidemiological study in Japanese university students. J Gastroenterol Hepatol 23(7 Pt 2):e29–e33. https://doi.org/10.1111/j.1440-1746.2007.05107.x
Sonnenberg A, Genta RM (2012) Low prevalence of Helicobacter pylori infection among patients with inflammatory bowel disease. Aliment Pharmacol Ther 35(4):469–476. https://doi.org/10.1111/j.1365-2036.2011.04969.x
Sporea I, Popescu A, van Blankenstein M, Sirli R, Focsea M, Danila M (2003) The prevalence of Helicobacter pylori infection in western Romania. Rom J Gastroenterol 12(1):15–18
Storskrubb T, Aro P, Ronkainen J, Sipponen P, Nyhlin H, Talley NJ, Engstrand L, Stolte M, Vieth M, Walker M, Agreus L (2008) Serum biomarkers provide an accurate method for diagnosis of atrophic gastritis in a general population: the Kalixanda study. Scand J Gastroenterol 43(12):1448–1455. https://doi.org/10.1080/00365520802273025
Tadesse E, Daka D, Yemane D, Shimelis T (2014) Seroprevalence of Helicobacter pylori infection and its related risk factors in symptomatic patients in southern Ethiopia. BMC Res Notes 7:834. https://doi.org/10.1186/1756-0500-7-834
Telaranta-Keerie A, Kara R, Paloheimo L, Harkonen M, Sipponen P (2010) Prevalence of undiagnosed advanced atrophic corpus gastritis in Finland: an observational study among 4,256 volunteers without specific complaints. Scand J Gastroenterol 45(9):1036–1041. https://doi.org/10.3109/00365521.2010.487918
Thjodleifsson B, Asbjornsdottir H, Sigurjonsdottir RB, Gislason D, Olafsson I, Cook E, Gislason T, Jogi R, Janson C (2007) Seroprevalence of Helicobacter pylori and cagA antibodies in Iceland, Estonia and Sweden. Scand J Infect Dis 39(8):683–689. https://doi.org/10.1080/00365540701225736
To T, Stanojevic S, Moores G, Gershon AS, Bateman ED, Cruz AA, Boulet LP (2012) Global asthma prevalence in adults: findings from the cross-sectional world health survey. BMC Public Health 12:204. https://doi.org/10.1186/1471-2458-12-204
Tsang KW, Lam WK, Chan KN, Hu W, Wu A, Kwok E, Zheng L, Wong BC, Lam SK (2000) Helicobacter pylori sero-prevalence in asthma. Respir Med 94(8):756–759. https://doi.org/10.1053/rmed.2000.0817
Tu S (2008) Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell 14(5):408–419. https://doi.org/10.1016/j.ccr.2008.10.011
Uchida T, Miftahussurur M, Pittayanon R, Vilaichone RK, Wisedopas N, Ratanachu-Ek T, Kishida T, Moriyama M, Yamaoka Y, Mahachai V (2015) Helicobacter pylori Infection in Thailand: a nationwide study of the CagA phenotype. PloS One 10(9):e0136775. https://doi.org/10.1371/journal.pone.0136775
Uter W, Stock C, Pfahlberg A, Guillen-Grima F, Aguinaga-Ontoso I, Brun-Sandiumenge C, Kramer A (2003) Association between infections and signs and symptoms of ‘atopic’ hypersensitivity—results of a cross-sectional survey among first-year university students in Germany and Spain. Allergy 58(7):580–584
van Rijt LS, Jung S, Kleinjan A, Vos N, Willart M, Duez C, Hoogsteden HC, Lambrecht BN (2005) In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma. J Exp Med 201(6):981–991. https://doi.org/10.1084/jem.20042311
Veldhoen M, Stockinger B (2006) TGFbeta1, a “Jack of all trades”: the link with pro-inflammatory IL-17-producing T cells. Trends Immunol 27(8):358–361. https://doi.org/10.1016/j.it.2006.06.001
von Hertzen L, Haahtela T (2005) Signs of reversing trends in prevalence of asthma. Allergy 60(3):283–292. https://doi.org/10.1111/j.1398-9995.2005.00769.x
Walker TD, Karemera M, Ngabonziza F, Kyamanywa P (2014) Helicobacter pylori status and associated gastroscopic diagnoses in a tertiary hospital endoscopy population in Rwanda. Trans R Soc Trop Med Hyg 108(5):305–307. https://doi.org/10.1093/trstmh/tru029
Wang G, Miyahara Y, Guo Z, Khattar M, Stepkowski SM, Chen W (2010) “Default” generation of neonatal regulatory T cells. J Immunol 185(1):71–78. https://doi.org/10.4049/jimmunol.0903806
Wang Q, Yu C, Sun Y (2013) The association between asthma and Helicobacter pylori: a meta-analysis. Helicobacter 18(1):41–53. https://doi.org/10.1111/hel.12012
Webb PM, Knight T, Greaves S, Wilson A, Newell DG, Elder J, Forman D (1994) Relation between infection with Helicobacter pylori and living conditions in childhood: evidence for person to person transmission in early life. BMJ 308(6931):750–753
Werme K, Bisseye C, Ouedraogo I, Yonli AT, Ouermi D, Djigma F, Moret R, Gnoula C, Nikiema JB, Simpore J (2015) Molecular diagnostics of Helicobacter pylori by PCR in patients in gastroenterology consultation at Saint Camille Medical Centre in Ouagadougou. Pan Afr Med J 21:123. 10.11604/pamj.2015.21.123.6001
Wewer V, Andersen LP, Paerregaard A, Gernow AB, Hart Hansen JP, Matzen P, Krasilnikoff PA (1998) The prevalence and related symptomatology of Helicobacter pylori in children with recurrent abdominal pain. Acta Paediatr 87(8):830–835
Windsor HM, Abioye-Kuteyi EA, Leber JM, Morrow SD, Bulsara MK, Marshall BJ (2005) Prevalence of Helicobacter pylori in Indigenous Western Australians: comparison between urban and remote rural populations. Med J Aust 182(5):210–213
Wu XW, Ji HZ, Yang MF, Wu L, Wang FY (2015) Helicobacter pylori infection and inflammatory bowel disease in Asians: a meta-analysis. World J Gastroenterol 21(15):4750–4756. https://doi.org/10.3748/wjg.v21.i15.4750
Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, Shah B, Chang SH, Schluns KS, Watowich SS, Feng XH, Jetten AM, Dong C (2008) Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29(1):44–56. https://doi.org/10.1016/j.immuni.2008.05.007
Yao G, Wang P, Luo XD, Yu TM, Harris RA, Zhang XM (2016) Meta-analysis of association between Helicobacter pylori infection and multiple sclerosis. Neurosci Lett 620:1–7. https://doi.org/10.1016/j.neulet.2016.03.037
Yogev N, Frommer F, Lukas D, Kautz-Neu K, Karram K, Ielo D, von Stebut E, Probst HC, van den Broek M, Riethmacher D, Birnberg T, Blank T, Reizis B, Korn T, Wiendl H, Jung S, Prinz M, Kurschus FC, Waisman A (2012) Dendritic cells ameliorate autoimmunity in the CNS by controlling the homeostasis of PD-1 receptor(+) regulatory T cells. Immunity 37(2):264–275. https://doi.org/10.1016/j.immuni.2012.05.025
Zevit N, Balicer RD, Cohen HA, Karsh D, Niv Y, Shamir R (2012) Inverse association between Helicobacter pylori and pediatric asthma in a high-prevalence population. Helicobacter 17(1):30–35. https://doi.org/10.1111/j.1523-5378.2011.00895.x
Zhang M, Liu M, Luther J, Kao JY (2010) Helicobacter pylori directs tolerogenic programming of dendritic cells. Gut Microbes 1(5):325–329. https://doi.org/10.4161/gmic.1.5.13052
Zhou S, Huang Y, Liang B, Dong H, Yao S, Chen Y, Xie Y, Long Y, Gong S, Zhou Z (2017) Systemic and mucosal pre-administration of recombinant Helicobacter pylori neutrophil-activating protein prevents ovalbumin-induced allergic asthma in mice. FEMS Microbiol Lett. https://doi.org/10.1093/femsle/fnw288
Zhou X, Wu J, Zhang G (2013) Association between Helicobacter pylori and asthma: a meta-analysis. Eur J Gastroenterol Hepatol 25(4):460–468. https://doi.org/10.1097/MEG.0b013e32835c280a
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Semper, R.P., Gerhard, M. (2017). The Lost Friend: H. pylori . In: Schmidt-Weber, C. (eds) Allergy Prevention and Exacerbation. Birkhäuser Advances in Infectious Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-69968-4_5
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