Semantic Interoperability of Clinical Data

  • Jacqueline Midlej do Espírito SantoEmail author
  • Claudia Bauzer Medeiros
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10649)


The interoperability of clinical information systems is particularly complicated due to the use of outdated technologies and the absence of consensus about standards. The literature applies standard-based approaches to achieve clinical data interoperability, but many systems do not adopt any standard, requiring a full redesigning process. Instead, we propose a generic computational approach that combines a hierarchical organization of mediator schemas to support the interoperability across distinct data sources. Second, our work takes advantage of knowledge bases to be linked to clinical data, and exploit these semantic linkages via queries. The paper shows case studies to validate our proposal.


Semantic interoperability Mediator Terminology Ontology 



Work partially financed by 1504650 (CAPES), 142243/2017-5 (CNPq), FAPESP/ Cepid in Computational Engineering and Sciences (2013/ 08293-7), INCT in Web Science. Our thanks to Hemocentro and HC collaborators, mainly Edson Kitaka, Profs. Fernando Costa and Erich de Paula.


  1. 1.
    IEEE standard computer dictionary: a compilation of IEEE standard computer glossaries. IEEE Std 610, pp. 1–217 (Jan 1991)Google Scholar
  2. 2.
    Azami, I., Malki, M., Tahon, C.: Integrating hospital information systems in healthcare institutions: a mediation architecture. J. Med. Syst. 36(5), 3123–3134 (2012)CrossRefGoogle Scholar
  3. 3.
    Berges, I., Bermudez, J., Illarramendi, A.: Toward semantic interoperability of electronic health records. IEEE Trans. Inf Technol. Biomed. 16(3), 424–431 (2012)CrossRefGoogle Scholar
  4. 4.
    Costa, C., Menárguez-Tortosa, M., Fernández-Breis, J.: Clinical data interoperability based on archetype transformation. J. Biomed. Info. 44(5), 869–880 (2011)CrossRefGoogle Scholar
  5. 5.
    Dogac, A., Laleci, G., Kirbas, S., Kabak, Y., Sinir, S., Yildiz, A., Gurcan, Y.: Artemis: deploying semantically enriched web services in the healthcare domain. Inf. Syst. 31(4–5), 321–339 (2006)CrossRefGoogle Scholar
  6. 6.
    Hosseini, M., Ahmadi, M., Dixon, B.: A service oriented architecture approach to achieve interoperability between immunization information systems in Iran. AMIA Annual Symposium Proceedings, pp. 1797–1805 (Nov 2014)Google Scholar
  7. 7.
    Jian, W., Hsu, C., Hao, T., Wen, H., Hsu, M., Lee, Y., Li, Y., Chang, P.: Building a portable data and information interoperability infrastructure - framework for a standard taiwan electronic medical record template. Comput. Methods Programs Biomed. 88(2), 102–111 (2007)CrossRefGoogle Scholar
  8. 8.
    Li, J., Zhou, T., Chu, J., Araki, K., Yoshihara, H.: Design and development of an international clinical data exchange system: the international layer function of the dolphin project. J. Am. Med. Info. Assoc. 18(5), 683–689 (2011)CrossRefGoogle Scholar
  9. 9.
    Luciano, J., Andersson, B., Batchelor, C., et al.: The translational medicine ontology and knowledge base: driving personalized medicine by bridging the gap between bench and bedside. J. Biomed. Semant. 2(suppl 2), 1–21 (2011)CrossRefGoogle Scholar
  10. 10.
    Müller, M.L., Ückert, F., Bürkle, T., Prokosch, H.U.: Cross-institutional data exchange using the clinical document architecture (CDA). Int. J. Med. Inform. 74(2–4), 245–256 (2005)CrossRefGoogle Scholar
  11. 11.
    Samwald, M., Jentzsch, A., Bouton, C., Kallesøe, C., Willighagen, E., Hajagos, J., Marshall, M., Prud’hommeaux, E., Hassanzadeh, O., Pichler, E., Stephens, S.: Linked open drug data for pharmaceutical research and development. J. Cheminform. 3(1), 19 (2011)CrossRefGoogle Scholar
  12. 12.
    Sartipi, K., Dehmoobad, A.: Cross-domain information and service interoperability. In: iWAS, pp. 25–32. ACM, New York (2008)Google Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Jacqueline Midlej do Espírito Santo
    • 1
    Email author
  • Claudia Bauzer Medeiros
    • 1
  1. 1.Institute of ComputingUniversity of Campinas - UNICAMP, BRACampinasBrazil

Personalised recommendations