This chapter explores the special context of Christian universities. There is an analysis of the shared nature and generic aims of these universities, the principal factors that mediate how their mission is carried out and the major challenges they encounter. Then the particular case of the Catholic university, the denominational category which sponsors by far the greatest number of universities is examined. The nature and purpose of a Catholic university is approached by wrestling with the often misunderstood relationship between faith and intellectual inquiry. This is followed first, by an exposure of factors (with special reference to culture) that influence how the mission of a Catholic university is interpreted and implemented; second, an interrogation of the cross-pressures and causes of resistance to this mission.