Abstract
Granulomatous skin diseases are a diverse group of disorders as chronic inflammatory responses to infectious and noninfectious antigens and/or other organic or inorganic materials the immune system is unable to eliminate. The diagnosis of granulomatous diseases relies heavily on clinical and pathological examination; the unifying finding is an inflammatory infiltrate predominantly composed of histiocytes, macrophages, and giant cells, sometimes showing collagen degeneration and caseation necrosis. The clinical manifestations are generally rare and may differ in their incidence and presentation in individuals with heavily pigmented ethnic skin.
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References
Rybicki BA, Major M, Popovich J, et al. Racial differences in sarcoidosis incidence: a 5-year study in a health maintenance organization. Am J Epidemiol. 1997;145:234–41.
Edmondstone WM, Wilson AG. Sarcoidosis in Caucasians, Blacks and Asians in London. Br J Dis Chest. 1985;79:27–36.
Jacyk WK. Cutaneous sarcoidosis in black South Africans. Int J Dermatol. 1999;38:841–5.
Marchell RM, Judson MA. Chronic cutaneous lesions of sarcoidosis. Clin Dermatol. 2007;25:295–302.
Minus HR, Grimes PE. Cutaneous manifestations of sarcoidosis in blacks. Cutis. 1983;32:361–3.
Sharma SK, Mohan A, Guleria JS. Clinical characteristics, pulmonary function abnormalities and outcome of prednisolone treatment in 106 patients with sarcoidosis. J Assoc Physicians India. 2001;49:697–704.
Roustan G, Yebra M, Rodriguez-Braojos O, et al. Cutaneous and pulmonary sarcoidosis in a patient with HIV after highly active antiretroviral therapy. Int J Dermatol. 2007;46:68–71.
Ramos-Casals M, Maña J, Nardi N, et al. Sarcoidosis in patients with chronic hepatitis C virus infection: analysis of 68 cases. Medicine (Baltimore). 2005;84(2):6.
Doherty CB, Rosen T. Evidence-based therapy for cutaneous sarcoidosis. Drugs. 2008;68:1361–83.
Lee JB, Koblenzer PS. Disfiguring cutaneous manifestation of sarcoidosis treated with thalidomide: a case report. J Am Acad Dermatol. 1998;39:835–8.
Georgiou S, Monastirli A, Pasmatzi E, et al. Cutaneous sarcoidosis: complete remission after oral isotretinoin therapy. Acta Derm Venereol. 1998;78:457–9.
Dhaille F, Viseux V, Caudron A, et al. Cutaneous sarcoidosis occurring during anti-TNF-alpha treatment: report of two cases. Dermatology. 2010;220:234–7.
Patterson JW, Fitzwater JE. Treatment of hypopigmented sarcoidosis with 8-methoxypsoralen and long wave ultraviolet light. Int J Dermatol. 1982;21:476–80.
Behbehani N, Jayakrishnan B, Khadadah M, et al. Long-term prognosis of sarcoidosis in Arabs and Asians: predictors of good outcome. Sarcoidosis Vasc Diffuse Lung Dis. 2006;23:209–14.
Studer EM, Calza AM, Saurat JH. Precipitating factors and associated diseases in 84 patients with granuloma annulare: a retrospective study. Dermatology. 1996;193:364–8.
Muhlemann MF, Williams DR. Localized granuloma annulare is associated with insulin-dependent diabetes mellitus. Br J Dermatol. 1984;111:325.
Wu W, Robinson-Bostom L, Kokkotou E, et al. Dyslipidemia in granuloma annulare: a case-control study. Arch Dematol. 2012;148:1131–6.
Li A, Hogan DJ, Sanusi ID, et al. Granuloma annulare and malignant neoplasms. Am J Dermatopathol. 2003;25:113–6.
Barksdale SK, Perniciaro C, Hailing KC, et al. Granuloma annulare in patients with malignant lymphoma: clinicopathologic study of thirteen new cases. J Am Acad Dermatol. 1994;31:42–8.
Evans MJ, Blessing K, Gray E. Pseudorheumatoid nodule (deep granuloma annulare) of childhood: clinicopathologic features of twenty patients. Pediatr Dermatol. 1994;11:6–9.
Chiang K, Bhalla R, Mesinkovska NA, et al. Periocular granuloma annulare: a case report and review of literature. Pediatr Dermatol. 2014;31:722–5.
Ratnavel RC, Norris PG. Perforating granuloma annulare: response to treatment with isotretinoin. J Am Acad Dermatol. 1995;32:126–7.
Simon M Jr, von den Driesch P. Antimalarials for control of disseminated granuloma annulare in children. J Am Acad Dermatol. 1994;31:1064–5.
Spadino S, Altomare A, Cainelli C, et al. Disseminated granuloma annulare: efficacy of cyclosporine therapy. Int J Immunopathol Pharmacol. 2006;19:433–8.
Peyri J, Moreno A. Marcoval: necrobiosis lipoidica. Semin Cutan Med Surg. 2007;26:87–9.
Boulton AJM, Cutfield RG, Abouganem D, et al. Necrobiosis lipoidica diabeticorum: a clinicopathologic study. J Am Acad Dermatol. 1988;18:530–7.
Quimby SR, Muller SA, Schroeter AL. The cutaneous immunopathology of necrobiosis lipoidica diabeticorum. Arch Dermatol. 1988;124:1364–71.
Uva L, Freitas J, Soares de Almeida L, et al. Squamous cell carcinoma arising in ulcerated necrobiosis lipoidica diabeticorum. Int Wound J. 2015;12:741–3.
Petzelbauer P, Wolff K, Tappeiner G. Necrobiosis lipoidica: treatment with systemic corticosteroids. Br J Dermatol. 1992;126:542–5.
Beattie PE, Dawe RS, Ibbotson SH, et al. UVA1 phototherapy for treatment of necrobiosis lipoidica. Clin Exp Dermatol. 2006;31:235–8.
Dogliotti M, Leibowitz M. Granulomatous ochronosis—a cosmetic-induced skin disorder in blacks. S Afr Med J. 1979;56:757–60.
Baumgartner M, Feldmann R, Breier F, et al. Sarcoidal granulomas in a cosmetic tattoo in association with pulmonary sarcoidosis. J Dtsch Dermatol Ges. 2010;8:900–2.
Collins P, Evans AT, Gray W, et al. Pulmonary sarcoidosis presenting as a granulomatous tattoo reaction. Br J Dermatol. 1994;130:658–62.
Suvanasuthi S, Wongpraparut C, Pattanaprichakul P, et al. Mycobacterium fortuitum cutaneous infection from amateur tattoo. J Med Assoc Thail. 2012;95:834–7.
Sherif S, Blakeway E, Fenn C, et al. A case of squamous cell carcinoma developing within a red-ink tattoo. J Cutan Med Surg. 2017;21:61–3. pii: 1203475416661311.
da Mota LM, Laurindo IM, dos Santos Neto LL. Demographic and clinical characteristics of a cohort of patients with early rheumatoid arthritis. Rev Bras Rheumatol. 2010;50:235–48.
Mebazaa A, Aounallah A, Naija N, et al. Dermatologic manifestations in inflammatory bowel disease in Tunisia. Tunis Med. 2012;90:252–7.
Wollina U, Haroske G. Pyoderma gangraenosum. Curr Opin Rheumatol. 2011;23:50–6.
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Kibbi, N., Kibbi, AG. (2018). Noninfectious Granulomas in Pigmented Skin. In: Orfanos, C., Zouboulis, C., Assaf, C. (eds) Pigmented Ethnic Skin and Imported Dermatoses. Springer, Cham. https://doi.org/10.1007/978-3-319-69422-1_29
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DOI: https://doi.org/10.1007/978-3-319-69422-1_29
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