Plasticity of the Muscle Stem Cell Microenvironment

  • Ivana Dinulovic
  • Regula Furrer
  • Christoph HandschinEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1041)


Satellite cells (SCs) are adult muscle stem cells capable of repairing damaged and creating new muscle tissue throughout life. Their functionality is tightly controlled by a microenvironment composed of a wide variety of factors, such as numerous secreted molecules and different cell types, including blood vessels, oxygen, hormones, motor neurons, immune cells, cytokines, fibroblasts, growth factors, myofibers, myofiber metabolism, the extracellular matrix and tissue stiffness. This complex niche controls SC biology—quiescence, activation, proliferation, differentiation or renewal and return to quiescence. In this review, we attempt to give a brief overview of the most important players in the niche and their mutual interaction with SCs. We address the importance of the niche to SC behavior under physiological and pathological conditions, and finally survey the significance of an artificial niche both for basic and translational research purposes.


Skeletal muscle Muscle regeneration Satellite cells Stem cell-niche Muscular dystrophies Extracellular matrix 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Ivana Dinulovic
    • 1
  • Regula Furrer
    • 1
  • Christoph Handschin
    • 1
    Email author
  1. 1.BiozentrumUniversity of BaselBaselSwitzerland

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