Fetal Membranes-Derived Stem Cells Microenvironment

  • Phelipe Oliveira Favaron
  • Maria Angelica MiglinoEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1041)


Recently, the regenerative medicine has been trying to congregate different areas such as tissue engineering and cellular therapy, in order to offer effective treatments to overcome several human and veterinary medical problems. In this regard, fetal membranes have been proposed as a powerful source for obtainment of multipotent stem cells with low immunogenicity, anti-inflammatory properties and nontumorigenicity properties for the treatment of several diseases, including replacing cells lost due to tissue injuries or degenerative diseases. Morpho-physiological data have shown that fetal membranes, especially the yolk sac and amnion play different functions according to the gestational period, which are direct related to the features of the microenvironment that their cells are subject. The characteristics of the microenvironment affect or controls important cellular events involved with proliferation, division and maintenance of the undifferentiated stage or differentiation, especially acting on the extracellular matrix components. Considering the importance of the microenvironment and the diversity of embryonic and fetal membrane-derived stem cells, this chapter will addressed advances in the isolation, phenotyping, characteristics of the microenvironment, and applications of yolk sac and amniotic membrane-derived stem cells for human and veterinary regenerative medicine.


Yolk sac Amnion Amniotic membrane Mesenchymal stem cells Extracellular matrix Cell therapy 



The authors thank the several members from the School of Veterinary Medicine and Animal Science, University of Sao Paulo-USP, for collaboration and technical assistance.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Phelipe Oliveira Favaron
    • 1
  • Maria Angelica Miglino
    • 1
    Email author
  1. 1.Surgery DepartmentSchool of Veterinary Medicine and Animal Science, University of Sao PauloSao PauloBrazil

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