Abstract
Toxicological outcomes arise from dose, effect, person exposed, route of exposure, and chemical structure. These aspects are discussed as well as examples of toxicology cases in the world and current solutions and standards addressing some of these issues. The story is set in Kenya where populations are exposed to high amounts of fluoride in the water.
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References
Lu FC, Kacew S. Lu’s basic toxicology: fundamentals, target organs and risk assessment: CRC Press; 2002.
Frumkin H. Environmental health: from global to local: John Wiley & Sons; 2016.
Mandrioli D, Silbergeld EK. Evidence from toxicology: the most essential science for prevention. Environ Health Perspect. 2016;124(1):6.
Liverman CT, Ingalls CE, Fulco CE, et al., editors. Institute of Medicine (US) Committee on toxicology and environmental health information resources for health professionals. Washington, DC: National Academies Press (US); 1997.
Agency for Toxic Substances and Disease Registry (ATSDR). Toxicological Profile for Manganese. U.S. Public Health Service, U.S. Department of Health and Human Services, Atlanta, GA; 2012. http://www.atsdr.cdc.gov/toxprofiles/index.asp
Leach RM, Harris ED. Manganese. In: O’Dell BL, Sunde RA, editors. Handbook of nutritionally essential minerals. New York: Marcel Dekker; 1997. p. 335–55.
Food and Nutrition Board, Institute of Medicine. Manganese. Dietary reference intakes for vitamin A, vitamin K, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press; 2001. p. 394–419.
Keen CL, Zidenberg-Cherr S. Manganese. In: Ziegler EE, Filer LJ, editors. Present knowledge in nutrition. 7th ed. Washington, DC: ILSI Press; 1996. p. 334–43.
Pal PK, Samii A, Calne DB. Manganese neurotoxicity: a review of clinical features, imaging and pathology. Neurotoxicology. 1999;20(2–3):227–38.
Aschner M, Aschner JL. Manganese neurotoxicity: cellular effects and blood-brain barrier transport. Neurosci Biobehav Rev. 1991;15(3):333–40.
Olson D. Mercury toxicity. 2016. http://emedicine.medscape.com/article/1175560-overview#a3
Agency for Toxic Substances and Disease Registry (ATSDR). Medical management guidelines for mercury. 2014. https://www.atsdr.cdc.gov/mmg/mmg.asp?id=106&tid=24
EPA. Health effects from exposure to mercury. https://www.epa.gov/mercury/health-effects-exposures-mercury
Rice D, Barone S Jr. Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models. Environ Health Perspect. 2000;108(Suppl 3):511–33.
Grandjean P. Methylmercury toxicity and functional programming. Reprod Toxicol. 2007;23(3):414–20.
Calderon R, Johnson C, Craun G, Dufour A, Karlin R, Sinks T, Valentine J. Health risks from contaminated water: do class and race matter? Toxicol Ind Health. 1993;9(5):879–900.
Evans GW, Kantrowitz E. Socioeconomic status and health: the potential role of environmental risk exposure. Annu Rev Public Health. 2002;23:303–31.
Ezzati M, Utziinger J, Cairncross S, Cohen AJ, Singer BH. Environmental risks in the developing world: exposure indicators of evaluating interventions, programmes, and policies. J Epidemiol Community Health. 2005;59:15–22.
Sigman H, Stafford S. Management of hazardous waste and contaminated land. Ann Rev Resour Econ. 2011;3:2–4.
WHO, World Health Organization. Global health and aging. National Institute for Aging, National Institute for Health; 2011. http://www.who.int/ageing/publications/global_health.pdf
WHO, World Health Organization. Tackling the global clean air challenge. 2011. http://www.who.int/mediacentre/news/releases/2011/air_pollution_20110926/en/index.html
Zolnikov TR, Blodgett Salafia E. Improved relationships in eastern Kenya from water interventions and access to water. Health Psychol. 2016;35(3):273.
The Guardian. Hundreds die in malaria outbreak in West Kenya. 1999. https://www.theguardian.com/world/1999/jul/22/3
Boleij JS, Ruigewaard P, Hoek F, Thairu H, Wafula E, Onyango F, De Koning H. Domestic air pollution from biomass burning in Kenya. Atmos Environ (1967). 1989;23(8):1677–81.
World Bank. Improved water resources. http://data.worldbank.org/indicator/SH.H2O.SAFE.ZS
Karanja NK, Njenga M, Kuria Gathuru P, Karanja A, Munyao P. Crop-livestock-waste interactions in Nakuru’s urban agriculture. In: Prain G, Karanja NK, Lee-Smith D, editors. African urban harvest: agriculture in the cities of Cameroon, Kenya and Uganda. New York and Ottawa: Springer and IDRC; 2010.
United Nations Environmental Protection. Environmental pollution and impacts on environmental health. 2017. http://www.unep.org/urban_environment/PDFs/DandoraWasteDump-ReportSummary.pdf
Kenya Law Resource Center. http://www.kenyalawresourcecenter.org/2011/07/management-of-hazardous-chemicals-and.html
Barczewski B. How well do environmental regulations work in Kenya?: a case study of the Thika highway improvement project. Center for Sustainable Urban Development; 2013.
World Health Organisation. Fluoride in drinking water. Geneva: World Health Organization; 2001. http://www.who.int/water_sanitation_health/publications/fluoride_drinking_water_full.pdf
World Health Organisation Expert Committee on Oral Health Status and Fluoride Use. Fluorides and oral health. WHO Technical Report Series No. 846. World Health Organisation, Geneva; 1994.
Nair KR, Manji F, Gitonga JN. The occurrence and distribution of fluoride in groundwaters of Kenya. East Afr Med J. 1984;61(7):503–12.
Toxicology Education Foundation. History of toxicology. 2016. http://toxedfoundation.org/history-of-toxicology/
Occupational Safety and Health Agency (OSHA). Circle chart. 2017. https://www.osha.gov/dte/grant_materials/fy10/sh-20839-10/circle_chart.pdf
Zolnikov TR. Limitations in small artisanal gold mining addressed by educational components paired with alternative mining methods. Sci Total Environ. 2012;419:1–6.
US EPA, United States Environmental Protection Agency. Mercury: health effects. http://www.epa.gov/mercury/effects.htm2011.
Poulin J, Gibb H, Pruss-Ustun A. Mercury: assessing the environmental burden of disease at national and local levels. In WHO Environmental burden of disease series 2008 (No. 16). OMS.
EPA. p,p’-Dichlorodiphenyltrichloroethane (DDT); CASRN 50-29-3. 1987. https://cfpub.epa.gov/ncea/iris/iris_documents/documents/subst/0147_summary.pdf
WHO. Nipah virus infection. 2017. http://www.who.int/csr/disease/nipah/en/
WHO. Toxic chemicals. 2017. http://www.who.int/heli/risks/toxics/chemicals/en/
Rietjens IM, Alink GM. Future of toxicology low-dose toxicology and risk−benefit analysis. Chem Res Toxicol. 2006;19(8):977–81.
Lin FF, Ai HT, Zhao HX, Lin J, Jhiang JY, et al. High fluoride and low iodine environment and subclinical cretinism in Xinjiang. Endem Dis Bull. 1991;6(2):62–7. [in Chinese]
Choi AL, Sun G, Zhang Y, Grandjean P. Developmental fluoride neurotoxicity: a systematic review and meta-analysis. Environ Health Perspect. 120:1362–8.
Jones S, Burt BA, Petersen PE, Lennon MA. The effective use of fluorides in public health. Bull World Health Organ. 2005;83(9):670–6.
Foo ML, McCullough EC, Foote RL, Pisansky TM, Shaw EG. Doses to radiation sensitive organs and structures located outside the radiotherapeutic target volume for four treatment situations. Int J Radiat Oncol Biol Phys. 1993;27(2):403–17.
Tølløfsrud PA, Kvittingen EA, Granum PE, Vøllo A. Botulism in newborn infants. Tidsskrift for den Norske laegeforening: tidsskrift for praktisk medicin, ny raekke. 1998;118(28):4355–6.
Massachusetts Deaths 2003 report. DPH, Center for Health Information, Statistics, Research and Evaluation; 2005.
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Zolnikov, T.R. (2018). Toxicology. In: Autoethnographies on the Environment and Human Health. Palgrave Macmillan, Cham. https://doi.org/10.1007/978-3-319-69026-1_7
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DOI: https://doi.org/10.1007/978-3-319-69026-1_7
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