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Tumor Deposits; Mechanisms, Morphology, and Differential Diagnosis

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Tumor Deposits

Abstract

Free tumor deposits or satellites are tumor nodules with regular or irregular contours, located away from the primary tumor mass, but within the lymphatic draining area, devoid of the morphological features of a lymph node. The morphological differential diagnosis of these lesions is with metastatic lymph nodes and the ones with perinodal invasion in particular. In most of the cases, the interobserver agreement about the classification of the lesions as tumor deposits or metastatic lymph nodes seems to be substantial with κ analysis. The first morphological and clinical recognition of these lesions was in colorectal carcinomas, but later they were noted in association with the malignant tumors of different organs and systems like the head and neck or gastrectomy specimens. They are a part of the lymph node staging of the colorectal carcinomas since 2009. The information about the mechanism of metastasis as tumor deposits is sparse compared with lymph node metastasis or intravascular distant metastasis. Perineural, perivascular, and lymphatic metastatic routes are proposed for the mechanism of tumor spread as tumor deposits. The neurotrophic and angiotrophic extravascular migratory metastasis mechanisms are discussed. Nearly all the research about angiotrophic extravascular migratory metastasis is related to malignant melanomas; the mechanism is discussed along with the possible implications for carcinomas. The mechanisms of tumor deposit formation still require clarification, and some questions rallying for answers about the topic are presented.

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Authors and Affiliations

  1. Department of Pathology, Dokuz Eylul University, Inciralti Balcova/Izmir, Turkey

    Sulen Sarioglu

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  1. Sulen Sarioglu
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Sarioglu, S. (2018). Tumor Deposits; Mechanisms, Morphology, and Differential Diagnosis. In: Tumor Deposits. Springer, Cham. https://doi.org/10.1007/978-3-319-68582-3_2

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  • DOI: https://doi.org/10.1007/978-3-319-68582-3_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-68581-6

  • Online ISBN: 978-3-319-68582-3

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