Abstract
Humanity is facing an increasing burden of chronic disease and an ageing population that will lead to more years lived with disability. Dealing with these issues is difficult, especially if we consider the deterioration of social ties and the decline in social connectedness, which may also impact on health and wellbeing. However, research on the association between social ties and health outcomes has been characterized by conceptual difficulties, controversy and simplistic models. Here, we (1) review the literature on the associations between social ties and health outcomes, (2) identify various mechanisms through which these associations may arise and (3) propose a model on which future research activity could be based. We observe that social ties are an important contributor to health outcomes that may rival the effects of many traditional risk factors including smoking, alcohol consumption and physical activity. A complex network of behavioural, psychological and physiological mechanisms drives the health of individuals, and sociostructural factors will either facilitate or impede desired health outcomes within community ecosystems. The GENIAL [genomics-environment-vagus nerve-social interaction-allostatic regulation-longevity] model is proposed, and important mediators and moderators are characterized along a pathway to wellbeing and longevity. A major regulatory role is given to the vagus nerve—indexed by heart rate variability—as it is responsible for a host of psychological and physiological processes that influence social ties, subsequent health and wellbeing. Future research needs to move beyond the disciplinary dilemma, initiate multidisciplinary exchange and facilitate new lines of interdisciplinary enquiry. We further argue that extending beyond the self by focusing on relationships with others and our connections to the environment will aid a much-needed transition to a more caring and understanding world.
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References
Cohen S. Social relationships and health. Am Psychol. 2004;59(8):676–84.
Berkman LF, Glass T, Brissette I, Seeman TE. From social integration to health: Durkheim in the new millennium. Soc Sci Med. 2000;51(6):843–57.
Diener E. Subjective well-being. Psychol Bull. 1984;95(3):542–75.
Seligman M. Flourish: a visionary new understanding of happiness and well-being. New York: Simon and Schuster; 2012.
Ryff CD. Psychological well-being revisited: advances in the science and practice of eudaimonia. Psychother Psychosom. 2014;83(1):10–28.
Friedman HS, Kern ML. Personality, well-being, and health. Annu Rev Psychol. 2014;65(1):719–42.
Ford BQ, Shallcross AJ, Mauss IB, Floerke VA, Gruber J. Desperately seeking happiness: valuing happiness is associated with symptoms and diagnosis of depression. J Soc Clin Psychol. 2014;33(10):890–905.
Mauss IB, Tamir M, Anderson CL, Savino NS. Can seeking happiness make people unhappy? Paradoxical effects of valuing happiness. Emotion. 2011;11(4):807–15.
Forgas JP. Don’t worry, be sad! On the cognitive, motivational, and interpersonal benefits of negative mood. Curr Dir Psychol Sci. 2013;22(3):225–32.
Kashdan T, Biswas-Diener R. The upside of your dark side: why being your whole self–not just your “good” self–drives success and fulfillment. New York: Plume Books; 2015. p. 1.
Kashdan T, Rottenberg J. Psychological flexibility as a fundamental aspect of health. Clin Psychol Rev. 2010;30(7):865–78.
Fredrickson BL, Losada MF. Positive affect and the complex dynamics of human flourishing. Am Psychol. 2005;60(7):678–86.
Fredrickson BL. Updated thinking on positivity ratios. Am Psychol. 2013;68(9):814–22.
Brown NJL, Sokal AD, Friedman HL. The complex dynamics of wishful thinking: the critical positivity ratio. Am Psychol. 2013;68(9):801–13.
Brown NJL, Sokal AD, Friedman HL. The persistence of wishful thinking. Am Psychol. 2014;69(6):629–32.
Quinn C, Harris A, Kemp AH. The interdependence of subtype and severity: contributions of clinical and neuropsychological features to melancholia and non-melancholia in an outpatient sample. J Int Neuropsychol Soc. 2012;18(2):361–9.
Quinn CR, Harris A, Felmingham K, Boyce P, Kemp AH. The impact of depression heterogeneity on cognitive control in major depressive disorder. Aust N Z J Psychiatry. 2012;46(11):1079–88.
Robinson D. Aristotle’s psychology. New York: Columbia University Press; 1999.
Ryan RM, Deci EL. On happiness and human potentials: a review of research on hedonic and eudaimonic well-being. Annu Rev Psychol. 2001;52(1):141–66.
Liu B, Floud S, Pirie K, Green J, Peto R, Beral V, et al. Does happiness itself directly affect mortality? The prospective UK million women study. Lancet. 2016;387(10021):874–81.
Ryff CD, Singer BH, Dienberg Love G. Positive health: connecting well-being with biology. Philos Trans R Soc B. 2004;359(1449):1383–94.
Fredrickson BL, Grewen KM, Coffey KA, Algoe SB, Firestine AM, Arevalo JMG, et al. A functional genomic perspective on human well-being. Proc Natl Acad Sci. 2013;110(33):13684–9.
Fredrickson BL, Grewen KM, Algoe SB, Firestine AM, Arevalo JMG, Ma J, et al. Psychological well-being and the human conserved transcriptional response to adversity. PLoS ONE. 2015;10(3):e0121839.
Disabato DJ, Goodman FR, Kashdan TB, Short JL, Jarden A. Different types of well-being? A cross-cultural examination of hedonic and eudaimonic well-being. Psychol Assess. 2016;28(5):471–82.
Kok BE, Coffey KA, Cohn MA, Catalino LI, Vacharkulksemsuk T, Algoe SB, et al. How positive emotions build physical health: perceived positive social connections account for the upward spiral between positive emotions and vagal tone. Psychol Sci. 2013;24(7):1123–32.
Coyne JC. Highly correlated hedonic and eudaimonic well-being thwart genomic analysis. Proc Natl Acad Sci U S A. 2013;110(45):E4183.
Brown N, Lomas T, Eiroá-Orosa FJ. The Routledge international handbook of critical positive psychology. London: Routledge; 2017.
Dubois CM, Beach SR, Kashdan TB, Nyer MB, Park ER, Celano CM, et al. Positive psychological attributes and cardiac outcomes: associations, mechanisms, and interventions. Psychosomatics. 2012;53(4):303–18.
Boehm JK, Kubzansky LD. The heart’s content: the association between positive psychological well-being and cardiovascular health. Psychol Bull. 2012;138(4):655–91.
Kok BE, Fredrickson BL. Upward spirals of the heart: autonomic flexibility, as indexed by vagal tone, reciprocally and prospectively predicts positive emotions and social connectedness. Biol Psychol. 2010;85(3):432–6.
Steptoe A, Deaton A, Stone AA. Subjective wellbeing, health, and ageing. Lancet. 2015;385(9968):640–8.
Kern ML, Porta Della SS, Friedman HS. Lifelong pathways to longevity: personality, relationships, flourishing, and health. J Pers. 2013;82(6):472–84.
Martin LR, Friedman HS, Tucker JS, Tomlinson-Keasey C, Criqui MH, Schwartz JE. A life course perspective on childhood cheerfulness and its relation to mortality risk. Personal Soc Psychol Bull. 2002;28(9):1155–65.
Shakya HB, Christakis NA. Association of facebook use with compromised well-being: a longitudinal study. Am J Epidemiol. 2017;185(3):203–11.
McDool E, Powell P, Roberts J, Taylor K. Social media use and children’s wellbeing: IZA DP No. 10412. IZA Institute of Labor Economics; 2016.
Kross E, Verduyn P, Demiralp E, Park J, Lee DS, Lin N, et al. Facebook use predicts declines in subjective well-being in young adults. PLoS ONE. 2013;8(8):e69841.
Valtorta NK, Kanaan M, Gilbody S, Ronzi S, Hanratty B. Loneliness and social isolation as risk factors for coronary heart disease and stroke: systematic review and meta-analysis of longitudinal observational studies. Heart. 2016;102(13):1009–16.
Holt-Lunstad J, Smith TB, Layton JB. Social relationships and mortality risk: a meta-analytic review. PLoS Med. 2010;7(7):e1000316.
Holt-Lunstad J, Smith TB, Baker M, Harris T, Stephenson D. Loneliness and social isolation as risk factors for mortality: a meta-analytic review. Perspect Psychol Sci. 2015;10(2):227–37.
Yang YC, Boen C, Gerken K, Li T, Schorpp K, Harris KM. Social relationships and physiological determinants of longevity across the human life span. Proc Natl Acad Sci. 2016;113(3):578–83.
Steptoe A, Shankar A, Demakakos P, Wardle J. Social isolation, loneliness, and all-cause mortality in older men and women. Proc Natl Acad Sci. 2013;110(15):5797–801.
Luo Y, Hawkley LC, Waite LJ, Cacioppo JT. Loneliness, health, and mortality in old age: a national longitudinal study. Soc Sci Med. 2012;74(6):907–14.
Hodge AM, English DR, Giles GG, Flicker L. Social connectedness and predictors of successful ageing. Maturitas. 2013;75(4):361–6.
Christakis NA, Fowler JH. The spread of obesity in a large social network over 32 years. N Engl J Med. 2007;357(4):370–9.
Bandura A. Health promotion by social cognitive means. Health Educ Behav. 2004;31(2):143–64.
Umberson D, Crosnoe R, Reczek C. Social relationships and health behavior across the life course. Annu Rev Sociol. 2010;36(1):139–57.
Friedman HS, Martin LR. The longevity project: surprising discoveries for health and long life from the landmark eight decade study. New York: Hudson Street Press; 2011.
Maunder R, Hunter J. Love, fear, and health: how our attachments to others shape health and health care. Toronto: University of Toronto Press; 2015.
Uchino BN, Bowen K, Carlisle M, Birmingham W. Psychological pathways linking social support to health outcomes: a visit with the “ghosts” of research past, present, and future. Soc Sci Med. 2012;74(7):949–57.
Hernandez LM, Blazer DG. The impact of social and cultural environment on health. In: Hernandez LM, Blazer DG, editors. Genes, behavior and the social environment: moving beyond the nature/nurture debate. Washington, DC: National Academies Press; 2006.
Wilson SM. An ecologic framework to study and address environmental justice and community health issues. Environ Justice. 2009;2(1):15–24.
Tay L, Tan K, Diener E, Gonzalez E. Social relations, health behaviors, and health outcomes: a survey and synthesis. Appl Psychol Health Well Being. 2012;5(1):28–78.
Uchino BN. Social support and health: a review of physiological processes potentially underlying links to disease outcomes. J Behav Med. 2006;29(4):377–87.
Durkheim E. Suicide: a study in sociology. Glencoe: Free Press; 1897. p. 1–427.
Eriksson M. Social capital and health – implications for health promotion. Glob Health Action. 2011;4(1):5611.
Bogg T, Roberts BW. Conscientiousness and health-related behaviors: a meta-analysis of the leading behavioral contributors to mortality. Psychol Bull. 2004;130(6):887–919.
Steel P, Schmidt J, Shultz J. Refining the relationship between personality and subjective well-being. Psychol Bull. 2008;134(1):138–61.
Jokela M, Batty GD, Nyberg ST, Virtanen M, Nabi H, Singh-Manoux A, et al. Personality and all-cause mortality: individual-participant meta-analysis of 3,947 deaths in 76,150 adults. Am J Epidemiol. 2013;178(5):667–75.
Mikulincer M, Shaver PR. Attachment in adulthood: structure, dynamics, and change. New York: Guilford Publications; 2007.
Puig J, Englund MM, Simpson JA, Collins WA. Predicting adult physical illness from infant attachment: a prospective longitudinal study. Health Psychol. 2013;32(4):409–17.
Bowlby J. Attachment and loss. 3. Loss. New York: Basic Books; 1980.
Bowlby J. Attachment and loss. 1. Attachment. New York: Basic Books; 1969.
Bowlby E. Attachment and Loss. 2. Separation: anger and anxiety. New York: Basic Books; 1998.
Vrtička P. The social neuroscience of attachment. In: Ibáñez A, Sedeño L, García AM, editors. Neuroscience and social science. New York: Springer; 2017.
Niedenthal PM, Brauer M, Robin L, Innes-Ker ÅH. Adult attachment and the perception of facial expression of emotion. J Pers Soc Psychol. 2002;82(3):419–33.
Lazarus R, Folkman S. Stress, appraisal, and coping. New York: Springer; 1984.
Keller A, Litzelman K, Wisk LE, Maddox T, Cheng ER, Creswell PD, et al. Does the perception that stress affects health matter? The association with health and mortality. Health Psychol. 2012;31(5):677–84.
Sheinbaum T, Kwapil TR, Ballespí S, Mitjavila M, Chun CA, Silvia PJ, et al. Attachment style predicts affect, cognitive appraisals, and social functioning in daily life. Front Psychol. 2015;6:296.
Lund R, Christensen U, Nilsson CJ, Kriegbaum M, Hulvej Rod N. Stressful social relations and mortality: a prospective cohort study. J Epidemiol Community Health. 2014;68(8):720–7.
Russ TC, Stamatakis E, Hamer M, Starr JM, Kivimaki M, Batty GD. Association between psychological distress and mortality: individual participant pooled analysis of 10 prospective cohort studies. BMJ. 2012;345:e4933.
Penwell LM, Larkin KT. Social support and risk for cardiovascular disease and cancer: a qualitative review examining the role of inflammatory processes. Health Psychol Rev. 2010;4(1):42–55.
Cacioppo JT, Hawkley LC. Social isolation and health, with an emphasis on underlying mechanisms. Perspect Biol Med. 2003;46(3):S39–52.
Sgoifo A, Koolhaas J, De Boer S, Musso E, Stilli D, Buwalda B, et al. Social stress, autonomic neural activation, and cardiac activity in rats. Neurosci Biobehav Rev. 1999;23(7):915–23.
Sgoifo A, Carnevali L, Grippo AJ. The socially stressed heart. Insights from studies in rodents. Neurosci Biobehav Rev. 2013;39:51–60.
Costoli T, Bartolomucci A, Graiani G, Stilli D, Laviola G, Sgoifo A. Effects of chronic psychosocial stress on cardiac autonomic responsiveness and myocardial structure in mice. Am J Physiol Heart Circ Physiol. 2004;286(6):H2133–40.
McEwen BS. Stress, adaptation, and disease: allostasis and allostatic load. Ann N Y Acad Sci. 1998;840(1):33–44.
Cohen S, Doyle WJ, Skoner DP, Rabin BS. Social ties and susceptibility to the common cold. JAMA. 1997;277:1940–4.
Steptoe A, Dockray S, Wardle J. Positive affect and psychobiological processes relevant to health. J Pers. 2009;77(6):1747–76.
Porges SW. Orienting in a defensive world: mammalian modifications of our evolutionary heritage. A polyvagal theory. Psychophysiology. 1995;32(4):301–18.
Porges SW. The polyvagal theory: phylogenetic substrates of a social nervous system. Int J Psychophysiol. 2001;42(2):123–46.
Porges SW. Social engagement and attachment: a phylogenetic perspective. Ann N Y Acad Sci. 2003;1008:31–47.
Porges SW. The polyvagal theory: neurophysiological foundations of emotions, attachment, communication, and self-regulation. New York: W.W. Norton & Company; 2011.
Thayer J, Lane RD. Claude Bernard and the heart-brain connection: further elaboration of a model of neurovisceral integration. Neurosci Biobehav Rev. 2009;33(2):81–8.
Thayer J, Hansen AL, Saus-Rose E, Johnsen BH. Heart rate variability, prefrontal neural function, and cognitive performance: the neurovisceral integration perspective on self-regulation, adaptation, and health. Ann Behav Med. 2009;37(2):141–53.
Thayer J, Ahs F, Fredrikson M, Sollers Iii JJ, Wager TD. A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health. Neurosci Biobehav Rev. 2012;36(2):747–56.
Smith R, Thayer J, Khalsa SS, Lane RD. The hierarchical basis of neurovisceral integration. Neurosci Biobehav Rev. 2017;75:274–96.
Mesulam MM. From sensation to cognition. Brain. 1998;121(Pt 6):1013–52.
Vrtička P, Vuilleumier P. Neuroscience of human social interactions and adult attachment style. Front Hum Neurosci. 2012;6:212.
Lieberman MD. Social cognitive neuroscience: a review of core processes. Annu Rev Psychol. 2007;58(1):259–89.
Fonagy P, Luyten P, Strathearn L. Borderline personality disorder, mentalization, and the neurobiology of attachment. Infant Ment Health J. 2011;32(1):47–69.
Diamond LM. Attachment style, current relationship security, and negative emotions: the mediating role of physiological regulation. J Soc Pers Relat. 2005;22(4):499–518.
Chunchai T, Samniang B, Sripetchwandee J, Pintana H, Pongkan W, Kumfu S, et al. Vagus nerve stimulation exerts the neuroprotective effects in obese-insulin resistant rats, leading to the improvement of cognitive function. Sci Rep. 2016;6(1):26866.
Samniang B, Shinlapawittayatorn K, Chunchai T, Pongkan W, Kumfu S, Chattipakorn SC, et al. Vagus nerve stimulation improves cardiac function by preventing mitochondrial dysfunction in obese-insulin resistant rats. Sci Rep. 2016;6(1):19749.
Jarczok MN, Koenig J, Mauss D, Fischer JE, Thayer J. Lower heart rate variability predicts increased level of C-reactive protein 4 years later in healthy, nonsmoking adults. J Intern Med. 2014;276(6):667–71.
Kemp AH, López SR, Passos VMA, Bittencourt MS, Dantas EM, Mill JG, et al. Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: a path modelling study. Biol Psychol. 2016;117:216–24.
Meyer-Lindenberg A, Tost H. Neural mechanisms of social risk for psychiatric disorders. Nat Neurosci. 2012;15(5):663–8.
Kumsta R, Heinrichs M. Oxytocin, stress and social behavior: neurogenetics of the human oxytocin system. Curr Opin Neurobiol. 2013;23(1):11–6.
Kogan A, Saslow LR, Impett EA, Oveis C, Keltner D, Rodrigues Saturn S. Thin-slicing study of the oxytocin receptor (OXTR) gene and the evaluation and expression of the prosocial disposition. Proc Natl Acad Sci. 2011;108(48):19189–92.
Bakermans-Kranenburg MJ, van Ijzendoorn MH. Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. Soc Cogn Affect Neurosci. 2008;3(2):128–34.
Rodrigues SM, Saslow LR, Garcia N, John OP, Keltner D. Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc Natl Acad Sci. 2009;106(50):21437–41.
Lucht MJ, Barnow S, Sonnenfeld C, Rosenberger A, Grabe HJ, Schroeder W, et al. Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Prog Neuro-Psychopharmacol Biol Psychiatry. 2009;33(5):860–6.
Kanthak MK, Chen FS, Kumsta R, Hill LK, Thayer J, Heinrichs M. Oxytocin receptor gene polymorphism modulates the effects of social support on heart rate variability. Biol Psychol. 2016;117:43–9.
Pearce E, Wlodarski R, Machin A, Dunbar RIM. Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality. Proc Natl Acad Sci U S A. 2017;8:201700712.
Dunbar RIM, Baron R, Frangou A, Pearce E, van Leeuwen EJC, Stow J, et al. Social laughter is correlated with an elevated pain threshold. Proc Biol Sci. 2012;279(1731):1161–7.
Weinstein D, Launay J, Pearce E, Dunbar RIM, Stewart L. Group music performance causes elevated pain thresholds and social bonding in small and large groups of singers. Evol Hum Behav. 2016;37(2):152–8.
Nummenmaa L, Tuominen L, Dunbar R, Hirvonen J, Manninen S, Arponen E, et al. Social touch modulates endogenous μ-opioid system activity in humans. NeuroImage. 2016;138:242–7.
Weaver ICG, Cervoni N, Champagne FA, D’alessio AC, Sharma S, Seckl JR, et al. Epigenetic programming by maternal behavior. Nat Neurosci. 2004;7(8):847–54.
King S, Dancause K, Turcotte-Tremblay A-M, Veru F, Laplante DP. Using natural disasters to study the effects of prenatal maternal stress on child health and development. Birth Defect Res C. 2013;96(4):273–88.
Cao-Lei L, Massart R, Suderman MJ, Machnes Z, Elgbeili G, Laplante DP, et al. DNA methylation signatures triggered by prenatal maternal stress exposure to a natural disaster: project ice storm. PLoS ONE. 2014;9(9):e107653.
Grizenko N, Fortier M-È, Gaudreau-Simard M, Jolicoeur C, Joober R. The effect of maternal stress during pregnancy on IQ and ADHD symptomatology. J Can Acad Child Adolesc Psychiatry. 2015;24(2):92–9.
Laplante DP, Brunet A, Schmitz N, Ciampi A, King S. Project ice storm: prenatal maternal stress affects cognitive and linguistic functioning in 5 1/2-year-old children. J Am Acad Child Adolesc Psychiatry. 2008;47(9):1063–72.
Dancause KN, Laplante DP, Fraser S, Brunet A, Ciampi A, Schmitz N, et al. Prenatal exposure to a natural disaster increases risk for obesity in 5½-year-old children. Pediatr Res. 2012;71(1):126–31.
Dancause KN, Veru F, Andersen RE, Laplante DP, King S. Prenatal stress due to a natural disaster predicts insulin secretion in adolescence. Early Hum Dev. 2013;89(9):773–6.
Kemp AH, Quintana DS. The relationship between mental and physical health: insights from the study of heart rate variability. Int J Psychophysiol. 2013;89(3):288–96.
Thayer J, Yamamoto SS, Brosschot JF. The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. Int J Cardiol. 2010;141(2):122–31.
Brosschot JF, Verkuil B, Thayer J. Exposed to events that never happen: generalized unsafety, the default stress response, and prolonged autonomic activity. Neurosci Biobehav Rev. 2017;74(Part B):287–96.
Kemp AH. Heart rate variability, affective disorders and health. In: Baune BT, Tully PJ, editors. Cardiovascular diseases and depression. Cham: Springer; 2016. p. 167–85.
Kok BE, Fredrickson BL. Evidence for the upward spiral stands steady: a response to Heathers, Brown, Coyne, and Friedman (2015). Psychol Sci. 2015;26(7):1144–6.
Okbay A, Baselmans BML, De Neve J-E, Turley P, Nivard MG, Fontana MA, et al. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. Nat Genet. 2016;48(6):624–33.
Cole SW, Hawkley LC, Arevalo JMG, Cacioppo JT. Transcript origin analysis identifies antigen-presenting cells as primary targets of socially regulated gene expression in leukocytes. Proc Natl Acad Sci. 2011;108(7):3080–5.
Brown NJL, MacDonald DA, Samanta MP, Friedman HL, Coyne JC. A critical reanalysis of the relationship between genomics and well-being. Proc Natl Acad Sci. 2014;111(35):12705–9.
Brown NJL, MacDonald DA, Samanta MP, Friedman HL, Coyne JC. More questions than answers: continued critical reanalysis of Fredrickson et al.’s studies of genomics and well-being. PLoS ONE. 2016;11(6):e0156415.
Fredrickson BL. Selective data analysis in Brown et al.’s continued critical reanalysis. PLoS ONE. 2016;11(8):e0160565.
Pavlov V, Tracey K. The vagus nerve and the inflammatory reflex-linking immunity and metabolism. Nat Rev Endocrinol. 2012;8(12):743–54.
Tracey KJ. Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest. 2007;117(2):289–96.
Tracey KJ. The inflammatory reflex. Nature. 2002;420(6917):853–9.
Kemp AH, Quintana DS, Kuhnert R-L, Griffiths K, Hickie IB, Guastella AJ. Oxytocin increases heart rate variability in humans at rest: implications for social approach-related motivation and capacity for social engagement. PLoS ONE. 2012;7(8):e44014.
Norman GJ, Berntson GG, Cacioppo JT, Morris JS, Malarkey WB, Devries AC. Oxytocin increases autonomic cardiac control: moderation by loneliness. Biol Psychol. 2011;86(3):174–80.
Jandackova VK, Britton A, Malik M, Steptoe A. Heart rate variability and depressive symptoms: a cross-lagged analysis over a 10-year period in the Whitehall II study. Psychol Med. 2016;46(10):2121–31.
Kemp AH, Quintana DS, Gray MA, Felmingham KL, Brown K, Gatt JM. Impact of depression and antidepressant treatment on heart rate variability: a review and meta-analysis. Biol Psychiatry. 2010;67(11):1067–74.
Kemp AH, Brunoni AR, Santos IS, Nunes MA, Dantas EM, Carvalho de Figueiredo R, et al. Effects of depression, anxiety, comorbidity, and antidepressants on resting-state heart rate and its variability: an ELSA-Brasil cohort baseline study. Am J Psychiatr. 2014;171(12):1328–34.
Brunoni AR, Kemp AH, Dantas EM, Goulart AC, Nunes MA, Boggio PS, et al. Heart rate variability is a trait marker of major depressive disorder: evidence from the sertraline vs. electric current therapy to treat depression clinical study. Int J Neuropsychopharmacol. 2013;16(9):1937–49.
Kemp AH, Quintana DS, Quinn CR, Hopkinson P, Harris AWF. Major depressive disorder with melancholia displays robust alterations in resting state heart rate and its variability: implications for future morbidity and mortality. Front Psychol. 2014;5:1387.
Berthoud H-R. The vagus nerve, food intake and obesity. Regul Pept. 2008;149(1–3):15–25.
Tracey KJ, Pavlov VA. The vagus nerve and the inflammatory reflex–linking immunity and metabolism. Nat Rev Endocrinol. 2012;8(12):743–54.
Follesa P, Biggio F, Gorini G, Caria S, Talani G, Dazzi L, et al. Vagus nerve stimulation increases norepinephrine concentration and the gene expression of BDNF and bFGF in the rat brain. Brain Res. 2007;1179:28–34.
Biggio F, Gorini G, Utzeri C, Olla P, Marrosu F, Mocchetti I, et al. Chronic vagus nerve stimulation induces neuronal plasticity in the rat hippocampus. Int J Neuropsychopharmacol. 2009;12(9):1209.
Gomez-Pinilla F. The influences of diet and exercise on mental health through hormesis. Ageing Res Rev. 2008;7(1):49–62.
Groves DA, Brown VJ. Vagal nerve stimulation: a review of its applications and potential mechanisms that mediate its clinical effects. Neurosci Biobehav Rev. 2005;29(3):493–500.
Vonck K, Raedt R, Naulaerts J, De Vogelaere F, Thiery E, Van Roost D, et al. Vagus nerve stimulation…25 years later! What do we know about the effects on cognition? Neurosci Biobehav Rev. 2014;45:63–71.
Stilling RM, Dinan TG, Cryan JF. Microbial genes, brain & behaviour-epigenetic regulation of the gut-brain axis. Genes Brain Behav. 2013;13(1):69–86.
Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, et al. Ingestion of lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011;108(38):16050–5.
Carter JB, Banister EW, Blaber AP. Effect of endurance exercise on autonomic control of heart rate. Sports Med. 2003;33(1):33–46.
Ling C, Rönn T. Epigenetic adaptation to regular exercise in humans. Drug Discov Today. 2014;19(7):1015–8.
Thayer J, Sternberg E. Beyond heart rate variability: vagal regulation of allostatic systems. Ann N Y Acad Sci. 2006;1088(1):361–72.
Huston JM, Tracey KJ. The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway and implications for therapy. J Intern Med. 2010;269(1):45–53.
Thayer J, Lane RD. The role of vagal function in the risk for cardiovascular disease and mortality. Biol Psychol. 2007;74(2):224–42.
Thayer J, Loerbroks A, Sternberg EM. Inflammation and cardiorespiratory control: the role of the vagus nerve. Respir Physiol Neurobiol. 2011;178(3):387–94.
Barberis SD, et al. A pluralist framework for the philosophy of social neuroscience. In: Ibáñez A, Sedeño L, García AM, editors. Neuroscience and social science. New York: Springer; 2017.
Fredrickson BL, Grewen KM. A functional genomic perspective on human well-being. Proc Natl Acad Sci U S A. 2013;110:13684–9.
Kiecolt-Glaser JK, McGuire L, Robles TF, Glaser R. Emotions, morbidity, and mortality: new perspectives from psychoneuroimmunology. Annu Rev Psychol. 2002;53(1):83–107.
Stapelberg NJ, Neumann DL, Shum DHK, McConnell H, Hamilton-Craig I. A topographical map of the causal network of mechanisms underlying the relationship between major depressive disorder and coronary heart disease. Aust N Z J Psychiatry. 2011;45(5):351–69.
Box G, Draper NR. Empirical model-building and response surfaces. New York: Wiley; 1987.
Twenge JM, Foster JD. Birth cohort increases in narcissistic personality traits among American college students, 1982–2009. Soc Psychol Personal Sci. 2010;1(1):99–106.
Statistical bulletin: families and households in the UK; 2016. www.ons.gov.uk.
Vespa J, Lewis JM, Kreider RM. America’s families and living arrangements: 2012 [Internet]. census.gov; 2013 [cited 2017 Apr 25]. https://www.census.gov/prod/2013pubs/p20-570.pdf.
Siegler V. Measuring national well-being-an analysis of social capital in the UK. Office of National Statistics; 2015.
Beutel ME, Klein EM, Brähler E, Reiner I, Jünger C, Michal M, et al. Loneliness in the general population: prevalence, determinants and relations to mental health. BMC Psychiatry. 2017;17(1):97.
Lau J. Social intelligence and the next generation. London: National Service Citizen; 2016.
Jackson J, Cochran SD. Loneliness and psychological distress. J Psychol. 1991;125(3):257–62.
Cacioppo JT, Hughes ME, Waite LJ, Hawkley LC, Thisted RA. Loneliness as a specific risk factor for depressive symptoms: cross-sectional and longitudinal analyses. Psychol Aging. 2006;21(1):140–51.
Chesney E, Goodwin GM, Fazel S. Risks of all-cause and suicide mortality in mental disorders: a meta-review. World Psychiatry. 2014;13(2):153–60.
Mental Health Foundation. The fundamental facts about mental illness. London: Mental Health Foundation; 2015.
Bloom DE, Cafiero E, Jané-Llopis E, Abrahams-Gessel S, Bloom LR, Fathima S, et al. The global economic burden of noncommunicable diseases. PGDA working papers. Program on the global demography of aging; 2012.
OECD. Mental health and work: United Kingdom. Paris: OECD Publishing; 2014.
Patel V, Maj M, Flisher AJ, De Silva MJ, Koschorke M, Prince M, et al. Reducing the treatment gap for mental disorders: a WPA survey. World Psychiatry. 2010;9(3):169–76.
Wang PS, Berglund PA, Olfson M, Kessler RC. Delays in initial treatment contact after first onset of a mental disorder. Health Serv Res. 2004;39(2):393–416.
Institute of Medicine (US) Committee on Quality of Health Care in America. Crossing the quality chasm: a new health system for the 21st century. Washington, DC: National Academies Press; 2001.
Nesse RM. Natural selection and the elusiveness of happiness. Philos Trans R Soc Lond B. 2004;359(1449):1333–47. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1693419/pdf/15347525.pdf
Gable SL, Haidt J. What (and why) is positive psychology? Rev Gen Psychol. 2005;9(2):103–10.
Sheldon KM, King L. Why positive psychology is necessary. Am Psychol. 2001;56(3):216–7.
Lyubomirsky S, Sheldon K, Schkade D. Pursuing happiness: the architecture of sustainable change. Rev Gen. 2005;9:111–31.
Parks AC, Biswas-Diener R. Positive interventions: past, present and future. In: Mindfulness, acceptance, and positive psychology. Oakland: Context Press; 2013.
Bragg R, Leck C. Good practice in social prescribing for mental health: The role of nature-based interventions. Natural England Commissioned Reports; 2016.
Song C, Ikei H, Miyazaki Y. Physiological effects of nature therapy: a review of the research in Japan. Int J Environ Res Public Health. 2016;13(8):781.
Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: global burden of disease study. Lancet. 1997;349(9063):1436–42.
Murray CJ, Lopez AD. Alternative projections of mortality and disability by cause 1990–2020: global burden of disease study. Lancet. 1997;349(9064):1498–504.
Lopez AD, Project DCP. Global burden of disease and risk factors. Oxford: Oxford University Press; 2006. p. 1.
Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE, et al. Global burden of disease attributable to mental and substance use disorders: findings from the global burden of disease study 2010. Lancet. 2013;382(9904):1575–86.
GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the global burden of disease study 2013. Lancet. 2014;385(9963):117–71.
Vos T, Barber RM, Bell B, Bertozzi-Villa A. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the global burden of disease study 2013. Lancet. 2015;386:743–800.
GBD 2015 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the global burden of disease study 2015. Lancet. 2016;388(10053):1603–58.
Shahady EJ. Barriers to care in chronic disease: how to bridge the treatment gap. Consultant. 2006;46:1149–52.
Eichstaedt JC, Schwartz HA, Kern ML, Park G, Labarthe DR, Merchant RM, et al. Psychological language on twitter predicts county-level heart disease mortality. Psychol Sci. 2015;26(2):159–69.
Nelson B, McGorry PD, Wichers M, Wigman JTW, Hartmann JA. Moving from static to dynamic models of the onset of mental disorder. JAMA Psychiat. 2017;74(5):528–34.
Wang H, Yu M, Ochani M, Amella CA, Tanovic M, Susarla S, et al. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature. 2003;421(6921):384–8.
Christakis NA, Fowler JH. Social contagion theory: examining dynamic social networks and human behavior. Stat Med. 2013;32(4):556–77.
Acknowledgements
Contributions to an early draft of this manuscript from several students (Ingrid Bjerknes Røyne and Jasmine Marie Rollings), enrolled in the taught Masters (MSc) programme in Psychology at Swansea University, are gratefully acknowledged. Constructive criticism from two anonymous reviewers was also particularly helpful in the development of the ideas presented herein.
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Kemp, A.H., Arias, J.A., Fisher, Z. (2017). Social Ties, Health and Wellbeing: A Literature Review and Model. In: Ibáñez, A., Sedeño, L., García, A. (eds) Neuroscience and Social Science. Springer, Cham. https://doi.org/10.1007/978-3-319-68421-5_17
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