Abstract
Many diagnostic methods using scintigraphic image sequence require decomposition of the sequence into tissue images and their time-activity curves. Standard procedure for this task is still manual selection of regions of interest (ROIs) which can be highly subjective due to their overlaps and poor signal-to-noise ratio. This can be overcome by automatic decomposition, however, the results may not have good physiological meaning. In this contribution, we aim to combine these approaches in semi-supervised procedure which is based on Bayesian blind source separation with the possibility of manual interaction after each run until an acceptable solution is obtained. The manual interaction is based on manual ROI placement and using its position to modify the corresponding prior parameters of the model. Performance of the proposed method is studied on real scintigraphic image sequence as well as on estimation of the specific diagnostic parameter on representative dataset of 10 scintigraphic sequences.
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References
Database of dynamic renal scintigraphy. http://dynamicrenalstudy.org. Accessed 28 Feb 2017
Aribi, Y., Hamza, F., Wali, A., Alimi, A.M., Guermazi, F.: An automated system for the segmentation of dynamic scintigraphic images. Appl. Med. Inform. 34(2), 1 (2014)
Aribi, Y., Wali, A., Alimi, A.M.: An intelligent system for renal segmentation. In: 2013 IEEE 15th International Conference on e-Health Networking, Applications & Services (Healthcom), pp. 11–15. IEEE (2013)
Bergmann, H., Dworak, E., König, B., Mostbeck, A., Šámal, M.: Improved automatic separation of renal parenchyma and pelvis in dynamic renal scintigraphy using fuzzy regions of interest. Eur. J. Nucl. Med. Mol. Imag. 26(8), 837–843 (1999)
Caglar, M., Gedik, G.K., Karabulut, E.: Differential renal function estimation by dynamic renal scintigraphy: influence of background definition and radiopharmaceutical. Nucl. Med. Commun. 29(11), 1002–1005 (2008)
Chen, L., Choyke, P.L., Chan, T.-H., Chi, C.-Y., Wang, G., Wang, Y.: Tissue-specific compartmental analysis for dynamic contrast-enhanced MR imaging of complex tumors. IEEE Trans. Med. Imag. 30(12), 2044–2058 (2011)
Durand, E., Blaufox, M.D., Britton, K.E., Carlsen, O., Cosgriff, P., Fine, E., Fleming, J., Nimmon, C., Piepsz, A., Prigent, A., et al.: International Scientific Committee of Radionuclides in Nephrourology (ISCORN) consensus on renal transit time measurements. In: Seminars in Nuclear Medicine, vol. 38, pp. 82–102. Elsevier (2008)
Garcia, E.V., Folks, R., Pak, S., Taylor, A.: Totally automatic definition of renal regions-of-interest from Tc-99m mag3 renograms: validation in patients with normal kidneys and in patients with suspected renal obstruction. Nucl. Med. Commun. 31(5), 366 (2010)
Lawson, R.S.: Application of mathematical methods in dynamic nuclear medicine studies. Phys. Med. Biol. 44(4), R57 (1999)
Šmídl, V., Quinn, A.: The Variational Bayes Method in Signal Processing. Springer, Heidelberg (2006)
Šmídl, V., Tichý, O.: Automatic regions of interest in factor analysis for dynamic medical imaging. In: 2012 9th IEEE International Symposium on Biomedical Imaging (ISBI), pp. 158–161. IEEE (2012)
Tichý, O., Šmídl, V.: Bayesian blind separation and deconvolution of dynamic image sequences using sparsity priors. IEEE Trans. Med. Imag. 34(1), 258–266 (2015)
Tichý, O., Šmídl, V.: Non-parametric Bayesian models of response function in dynamic image sequences. Comput. Vis. Image Underst. 151, 90–100 (2016)
Šámal, M., Nimmon, C.C., Britton, K.E., Bergmann, H.: Relative renal uptake and transit time measurements using functional factor images and fuzzy regions of interest. Eur. J. Nucl. Med. Mol. Imag. 25(1), 48–54 (1998)
Acknowledgements
This work was supported by the Grant Agency of the Czech Technical University in Prague, grant No. SGS17/193/OHK4/3T/14.
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Bódiová, L., Tichý, O., Šmídl, V. (2018). Semi-supervised Bayesian Source Separation of Scintigraphic Image Sequences. In: Tavares, J., Natal Jorge, R. (eds) VipIMAGE 2017. ECCOMAS 2017. Lecture Notes in Computational Vision and Biomechanics, vol 27. Springer, Cham. https://doi.org/10.1007/978-3-319-68195-5_6
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