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Precision Molecular Pathology of Liver Cancer pp 17–32Cite as

Histologic Classification of Hepatocellular Carcinoma and Its Clinical Implications

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Abstract

This chapter focuses on the histologic classification of hepatocellular carcinoma (HCC) with an emphasis on the clinical implications of the various subtypes. Scirrhous, steatohepatitic, lymphoepithelioma-like, fibrolamellar, sarcomatoid, undifferentiated, and diffuse cirrhosis-like HCC along with a brief discussion of combined hepatocellular-cholangiocarcinoma will be discussed.

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References

  1. Krings G, Ramachandran R, Jain D, Wu TT, Yeh MM, Torbenson M, et al. Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma. Mod Pathol. 2013;26(6):782–91.

    Article  CAS  PubMed  Google Scholar 

  2. MacSween RNM, Burt AD, Portmann B, Ferrell LD. MacSween’s pathology of the liver. 6th ed. Edinburgh, New York: Churchill Livingstone/Elsevier; 2012. xiii, 1020 p.

    Google Scholar 

  3. Shafizadeh N, Kakar S. Diagnosis of well-differentiated hepatocellular lesions: role of immunohistochemistry and other ancillary techniques. Adv Anat Pathol. 2011;18(6):438–45.

    Article  CAS  PubMed  Google Scholar 

  4. International Consensus Group for Hepatocellular Neoplasia. The International Consensus Group for Hepatocellular Neoplasia. Pathologic diagnosis of early hepatocellular carcinoma: a report of the international consensus group for hepatocellular neoplasia. Hepatology. 2009;49(2):658–64.

    Article  Google Scholar 

  5. WHO classification of tumours of the digestive system. IARC Press; 2010.

    Google Scholar 

  6. Lim II, Farber BA, LaQuaglia MP. Advances in fibrolamellar hepatocellular carcinoma: a review. Eur J Pediatr Surg. 2014;24(6):461–6.

    Article  PubMed  Google Scholar 

  7. Salomao M, Yu WM, Brown RS, Emond JC, Lefkowitch JH. Steatohepatitic hepatocellular carcinoma (SH-HCC): a distinctive histological variant of HCC in hepatitis C virus-related cirrhosis with associated NAFLD/NASH. Am J Surg Pathol. 2010;34(11):1630–6.

    PubMed  Google Scholar 

  8. Yeh MM, Liu Y, Torbenson M. Steatohepatitic variant of hepatocellular carcinoma in the absence of metabolic syndrome or background steatosis: a clinical, pathological, and genetic study. Hum Pathol. 2015;46(11):1769–75.

    Article  PubMed  Google Scholar 

  9. Mitchell KA. Hepatocellular carcinoma: histologic considerations: pure, mixed, and motley. J Clin Gastroenterol. 2013;47(Suppl):S20–6.

    Article  PubMed  Google Scholar 

  10. Patel KR, Liu TC, Vaccharajani N, Chapman WC, Brunt EM. Characterization of inflammatory (lymphoepithelioma-like) hepatocellular carcinoma: a study of 8 cases. Arch Pathol Lab Med. 2014;138(9):1193–202.

    Article  PubMed  Google Scholar 

  11. Si MW, Thorson JA, Lauwers GY, DalCin P, Furman J. Hepatocellular lymphoepithelioma-like carcinoma associated with Epstein Barr virus: a hitherto unrecognized entity. Diagn Mol Pathol. 2004;13(3):183–9.

    Article  PubMed  Google Scholar 

  12. Shafizadeh N, Kakar S. Hepatocellular carcinoma: histologic subtypes. Surg Pathol Clin. 2013;6(2):367–84.

    Article  PubMed  Google Scholar 

  13. Jakate S, Yabes A, Giusto D, Naini B, Lassman C, Yeh MM, et al. Diffuse cirrhosis-like hepatocellular carcinoma: a clinically and radiographically undetected variant mimicking cirrhosis. Am J Surg Pathol. 2010;34(7):935–41.

    Article  PubMed  Google Scholar 

  14. Akiba J, Nakashima O, Hattori S, Tanikawa K, Takenaka M, Nakayama M, et al. Clinicopathologic analysis of combined hepatocellular-cholangiocarcinoma according to the latest WHO classification. Am J Surg Pathol. 2013;37(4):496–505.

    Article  PubMed  Google Scholar 

  15. Schlageter M, Terracciano LM, D’Angelo S, Sorrentino P. Histopathology of hepatocellular carcinoma. World J Gastroenterol. 2014;20(43):15955–64.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Maida M, Orlando E, Cammà C, Cabibbo G. Staging systems of hepatocellular carcinoma: a review of literature. World J Gastroenterol. 2014;20(15):4141–50.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Duseja A. Staging of hepatocellular carcinoma. J Clin Exp Hepatol. 2014;4(Suppl 3):S74–9.

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA

    Amy Leigh Collinsworth M.D.

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  1. Amy Leigh Collinsworth M.D.
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Correspondence to Amy Leigh Collinsworth M.D. .

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Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Rutgers Robert Wood Johnson Medical School and New Jersey Medical School, Newark, New Jersey, USA

    Chen Liu

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Collinsworth, A.L. (2018). Histologic Classification of Hepatocellular Carcinoma and Its Clinical Implications. In: Liu, C. (eds) Precision Molecular Pathology of Liver Cancer. Molecular Pathology Library. Springer, Cham. https://doi.org/10.1007/978-3-319-68082-8_2

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  • DOI: https://doi.org/10.1007/978-3-319-68082-8_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-68080-4

  • Online ISBN: 978-3-319-68082-8

  • eBook Packages: MedicineMedicine (R0)

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