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Immunomodulatory Drugs and Monoclonal Antibodies

  • Howard A. Liebman
Chapter

Abstract

Autoimmune disorders result for either congenital or acquired defects in central or peripheral immune tolerance. A genetic propensity may underlie the development of most such disorders, but an external trigger may be required for the eventual development of the autoimmune disease. The development of pharmacologic agents to treat such disorders by inducing self-tolerance has progressed over the last 60 years. Historically termed immunosuppressive agents, it is now understood that they may modulate the immune system varied and unexpected ways. While many of the original immune-modulatory agents were cytotoxic drugs developed to treat lymphoid and myeloid malignancies, newer agents target specific immune cell populations, immune signaling pathways, immune cellular trafficking, and signaling molecules such as chemokines and cytokines. In particular, monoclonal antibodies that inhibit cytokine or cytokine receptors have become important immune-modulating agents in autoimmune disease.

Keywords

Autoimmunity Immune modulation Immunosuppression 

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Jane Anne Nohl Division of Hematology and Center for the Study of Blood DiseasesKeck School of Medicine of the University of Southern CaliforniaLos AngelesUSA
  2. 2.Norris Cancer CenterLos AngelesUSA

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