Abstract
In retrospect, this book firstly reviewed recent CMOS biosensors for in vitro diagnosis according to their transducing mechanisms (Chap. 2). Among these, NMR-based detection is a promising transducing mechanism as it averts complex post-processing on the CMOS chip and surface modification process to immobilize the probe. Still, there exist some challenges such as magnetic field instability and arduous sample management inside the space-limiting magnet. Thus, the essences of the researches around this book are to implement the NMR system on CMOS chips and streamline the experimental procedure.
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References
D.A. Hall, J.S. Daniels, B. Geuskens, N. Tayebi, G.M. Credo, D.J. Liu, et al., A nanogap transducer array on 32nm CMOS for electrochemical DNA sequencing, in IEEE International Solid-State Circuits Conference (ISSCC) Digest of Technical Papers, 2016, pp. 288–289
L. Sandeau, C. Vuillaume, S. Contie, E. Grinenval, F. Belloni, H. Rigneault, et al., Large area CMOS bio-pixel array for compact high sensitive multiplex biosensing. Lab Chip 15(3), 877–881 (2015)
H. Norian, R.M. Field, I. Kymissis, K.L. Shepard, An integrated CMOS quantitative-polymerase-chain-reaction lab-on-chip for point-of-care diagnostics. Lab Chip 14(20), 4076–4084 (2014)
C. Toumazou, L.M. Shepherd, S.C. Reed, G.I. Chen, A. Patel, D.M. Garner, et al., Simultaneous DNA amplification and detection using a pH-sensing semiconductor system. Nat. Methods 10(7), 641–646 (2013)
Y. Huang, A.J. Mason, Lab-on-CMOS integration of microfluidics and electrochemical sensors. Lab Chip 13(19), 3929–3934 (2013)
R.R. Singh, L. Leng, A. Guenther, R. Genov, A CMOS-microfluidic chemiluminescence contact imaging microsystem. IEEE J. Solid State Circuits 47(11), 2822–2833 (2012)
X. Liu, L. Li, A.J. Mason, High-throughput impedance spectroscopy biosensor array chip. Philos. Trans. R. Soc. London, Ser. A 372(2012), 20130107 (2014)
G. Wang, D. Teng, Y.T. Lai, Y.W. Lu, Y. Ho, C.Y. Lee, Field-programmable lab-on-a-chip based on microelectrode dot array architecture. IET Nanobiotechnol. 8(3), 163–171 (2014)
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Lei, KM., Mak, PI., Law, MK., Martins, R.P. (2018). Conclusion and Outlook. In: Handheld Total Chemical and Biological Analysis Systems. Springer, Cham. https://doi.org/10.1007/978-3-319-67825-2_5
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DOI: https://doi.org/10.1007/978-3-319-67825-2_5
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