State-of-the-Art CMOS In Vitro Diagnostic Devices

  • Ka-Meng Lei
  • Pui-In Mak
  • Man-Kay Law
  • Rui Paulo Martins


CMOS technology enables low-cost and large-scale integration of transistors and physical sensing materials on tiny chips (e.g., <1 cm2), seamlessly combining the two key functions of biosensors: transducing and signal processing. Recent CMOS biosensors unified different transducing mechanisms (impedance, fluorescence, and nuclear spin), and readout electronics have demonstrated competitive sensitivity for in vitro diagnosis such as detection of DNA (down to 10 aM), protein (down to 10 fM), or bacteria/cell (single cell). Herein, we detail the recent advances of CMOS biosensors, centering on their key principles, requisites, and applications. They together may contribute to the advance of our healthcare system that should be decentralized by broadly utilizing point-of-care diagnostic tools.


Biosensor Cell Chemical CMOS Deoxyribonucleic acid (DNA) In vitro diagnosis Lab-on-a-chip Point of care Protein 


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Ka-Meng Lei
    • 1
  • Pui-In Mak
    • 2
  • Man-Kay Law
    • 1
  • Rui Paulo Martins
    • 2
    • 3
  1. 1.State-Key Laboratory of Analog and Mixed-Signal VLSIUniversity of MacauMacauChina
  2. 2.State-Key Laboratory of Analog and Mixed-Signal VLSI and FST-ECEUniversity of MacauMacauChina
  3. 3.Instituto Superior Técnico Universidade de LisboaLisbonPortugal

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