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Implantable Microsystems for Personalised Anticancer Therapy

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Book cover CMOS Circuits for Biological Sensing and Processing

Abstract

The Implantable Microsystems for Personalised Anti-Cancer Therapy (IMPACT) project aims to produce an implantable wireless sensor device for monitoring tumour physiology. Real-time measurements will be used to improve radiotherapy by allowing treatment to be responsively delivered at the most effective time and location. We are developing miniaturised microfabricated sensors for measuring local oxygen concentration and pH within the tumour, using technologies that are amenable to integration on CMOS. In addition, we have established proof of concept for a range of electrochemical biosensors that can respond to enzyme biomarkers. Together these sensors will allow comprehensive monitoring of tissue physiology before and after radiotherapy treatment. For clinical use, the complete system will be equipped with circuits for wireless power and communications and packaged in biocompatible materials. This is a very challenging application for sensors integrated on CMOS. Here we provide a brief background to medical aspects of the work and describe our progress towards solving the engineering challenges it has presented.

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Acknowledgements

This work was supported by the funding from the UK Engineering and Physical Sciences Research Council, through the Implantable Microsystems for Personalised Anti-Cancer Therapy (IMPACT) programme grant (EP/K034510/1).

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Authors and Affiliations

  1. School of Engineering, University of Edinburgh, King’s Buildings, Colin Maclaurin Road, Edinburgh, EH9 3DW, UK

    Jamie R. K. Marland, Ewen O. Blair, Brian W. Flynn, Liyu Huang, Stewart Smith, Andreas Tsiamis & Alan F. Murray

  2. School of Chemistry, University of Edinburgh, Joseph Black Building, David Brewster Road, Edinburgh, EH9 3FJ, UK

    Eva González-Fernández & Matteo Staderini

  3. Cancer Research UK Edinburgh Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XR, UK

    Ian H. Kunkler

  4. Division of Pathology Laboratories, University of Edinburgh, Western General Hospital, Crewe Road South, Edinburgh, EH4 2XU, UK

    Carol Ward

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  1. Jamie R. K. Marland
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    Srinjoy Mitra

  2. School of Engineering, University of Glasgow, Glasgow, United Kingdom

    David R. S. Cumming

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Marland, J.R.K. et al. (2018). Implantable Microsystems for Personalised Anticancer Therapy. In: Mitra, S., Cumming, D. (eds) CMOS Circuits for Biological Sensing and Processing. Springer, Cham. https://doi.org/10.1007/978-3-319-67723-1_11

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