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Exogenous Radionanomedicine: Inorganic Nanomaterials

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Radionanomedicine

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

Roles of nuclear medicine and molecular imaging in cancer diagnosis and therapy are constantly evolving. Single-photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging allows the investigation of not only morphological but also functional characteristics of tumor tissues and possess distinct advantageous characteristics, such as high specificity and sensitivity, excellent quantifiability and virtually no tissue penetration limit. Nanoparticles, as multifunctional materials, hold the potential of being surface-engineered, conjugated to numerous targeting agents while carrying therapeutic or diagnostic agents and, thus, can provide the platforms needed for enhancing imaging and therapy efficacy and specificity; hence a large number of nanocarriers have been radiolabeled with a vast array of SPECT and PET agents for preclinical studies. In this context, radiolabeled nanoparticles hold the potential to deeply impact the science of clinical practice, from disease diagnosis to patient management. This chapter provides a comprehensive overview of the methods of synthesis, radiolabeling and further applications of the most commonly used nanoparticles in radionanomedicine.

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Acknowledgements

This work was supported, in part, by the University of Wisconsin —Madison, the National Institutes of Health (NIBIB/NCI 1R01CA169365, 1R01EB021336, P30CA014520), the American Cancer Society (125246-RSG-13-099-01-CCE) and CNPq (Brazilian National Council for Scientific and Technological Development).

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Authors and Affiliations

  1. Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, 53705, USA

    Carolina A. Ferreira & Weibo Cai

  2. Department of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, 53705, USA

    Shreya Goel & Weibo Cai

  3. Departments of Radiology and Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, USA

    Weibo Cai

  4. University of Wisconsin Carbone Cancer Center, Madison, WI, 53792, USA

    Weibo Cai

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  1. Carolina A. Ferreira
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Correspondence to Shreya Goel or Weibo Cai .

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  1. Department of Nuclear Medicine, Seoul National University, Seoul, Korea (Republic of)

    Dong Soo Lee

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Ferreira, C.A., Goel, S., Cai, W. (2018). Exogenous Radionanomedicine: Inorganic Nanomaterials. In: Lee, D. (eds) Radionanomedicine. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-67720-0_2

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