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Preclinical PET and SPECT for Radionanomedicine

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Radionanomedicine

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

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Abstract

Quantitative evaluation of in vivo biodistribution is a prerequisite for the development of new targeted theranostic probes in nanomedicine. Here in this chapter the principles of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) were explained. These two modalities are now popularly used for small animal studies and yield valuable information of the biodistribution, pharmacokinetics and final fates of radionanomedicines injected systemically. Great penetration depth, no background signal and the high sensitivity of PET and SPECT are the advantages for accurate quantification of in vivo biodistribution. MRI as well as CT was added to these modalities and clarifies the anatomical details. Simultaneous or sequential acquisition of PET/CT or PET/MRI allow the understanding of the accurate anatomical distribution of the administered radiolabeled nanomaterials. In this chapter, basic technical aspects and the application to radionanomedicine of PET and SPECT are detailed.

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Authors and Affiliations

  1. Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea

    Hyung-Jun Im

  2. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea

    Gi Jeong Cheon

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  1. Hyung-Jun Im
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Correspondence to Hyung-Jun Im .

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  1. Department of Nuclear Medicine, Seoul National University, Seoul, Korea (Republic of)

    Dong Soo Lee

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Im, HJ., Cheon, G.J. (2018). Preclinical PET and SPECT for Radionanomedicine. In: Lee, D. (eds) Radionanomedicine. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-67720-0_15

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