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Radiolabeling Method: Core/Surface Labeling, Chemical and Physical Labeling

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Radionanomedicine

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

Radiolabeled nanomaterials can be used for diagnosis, therapy and theranostics of certain diseases. The core concept of radionanomedicine relies on efficient and reliable radiolabeling methods, to bind appropriate isotope with well-functionalized nanoparticles (NPs), and the use of tracer amounts of radiolabeled NPs. In this chapter, we focused on the three issues of producing radiolabeled NPs: choosing appropriate radionuclides for labeling, construction of well-functionalized NPs with surface modification and different labeling methods of NPs with radionuclides. Firstly, choosing ideal isotope starts from understanding the characteristics of each isotopes, such as half-life, decay energy and availability, and understanding of purpose of the study. Secondly, to increase the specific delivery of NPs to the target tissues while decreasing the nonspecific binding to normal tissues well functionalized NPs are necessary, which can be achieved by surface modification. Especially, micelle encapsulation method is an efficient method for producing multifunctional NPs. Finally, ideal labeling method should be adopted, which should not only be quick, easy, and highly efficient but also should not change the biological properties of target molecules. Both intrinsic and extrinsic radiolabeling methods should be chosen in the base of thorough understanding of pros and cons of each labeling methods. In conclusion, the development of the methods to enable surface labeling with ligands and chelators should be solved first. The development of the imaging methods to track the in vivo administered radiolabeled NPs is the next issue to be addressed. With the improvement of above-mentioned issues, radiolabeled NPs can be successfully translated to clinical use.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, 03080, Republic of Korea

    Dong Soo Lee, Minseok Suh & Yun-Sang Lee

  2. Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 03080, Republic of Korea

    Dong Soo Lee, Minseok Suh & Yun-Sang Lee

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    Dong Soo Lee

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Lee, D.S., Suh, M., Lee, YS. (2018). Radiolabeling Method: Core/Surface Labeling, Chemical and Physical Labeling. In: Lee, D. (eds) Radionanomedicine. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-67720-0_11

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