Abstract
The amoeba and ciliates are protozoan parasites that have been causing illness in humans since antiquity. The most relevant foodborne parasites of these groups are Entamoeba histolytica and Balantidium coli. Entamoeba dispar has been identified mostly in asymptomatic patients however, reports demonstrating invasive amebiasis caused by E. dispar may indicate various levels of pathogenicity. In recent years, studies on the pathogenesis and immune responses to amoebiasis are providing insights on how to control this parasitosis that affects more than 50 million people annually.This chapter will address the various aspects of these parasites, from the biology, life cycle, clinical presentation, and treatment.
References
Acuna-Soto, R., Maguire, J. H., & Wirth, D. F. (2000). Gender distribution in asymptomatic and invasive amebiasis. The American Journal of Gastroenterology, 95, 1277–1283.
Anargyrou, K., Petrikkos, G. L., Suller, M. T., Skiada, A., Siakantaris, M. P., Osuntoyinbo, R. T., Pangalis, G., & Vaiopoulos, G. (2003). Pulmonary Balantidium coli infection in a leukemic patient. American Journal of Hematology, 73, 180–183.
Garcia, L and Bruckner, DA. (1993). Intestinal protozoa: Flagellates and ciliates. In L. S. Garcia & D. A. Bruckner (Eds.), Diagnostic medical parasitology (Vol. 3, pp. 31–44). Washington, DC: American Society for Microbiology.
Anonymous. (1997). WHO/PAHO/UNESCO report. A consultation with experts on amoebiasis. Mexico City, Mexico 28–29 January, 1997. Epidemiological Bulletin, 18, 13–14.
Arhets, P., Olivo, J. C., Gounon, P., Sansonetti, P., & Guillen, N. (1998). Virulence and functions of myosin II are inhibited by overexpression of light meromyosin in Entamoeba histolytica. Molecular Biology of the Cell, 9, 1537–1547.
Basset, D., Gaumerais, H., & Basset-Pougnet, A. (1986). Intestinal parasitoses in children of an Indian community of Bolivian altiplano. Bulletin De La Societe De Pathologie Exotique Et De Ses Filiales, 79, 237–246.
Bruckner, D. A. (1992). Amebiasis. Clinical Microbiology Reviews, 5, 356–369.
Butler, W. P. (1996). Dientamoeba fragilis. An unusual intestinal pathogen. Digestive Diseases and Sciences, 41, 1811–1813.
Campbell, D., Mann, B. J., & Chadee, K. (2000). A subunit vaccine candidate region of the Entamoeba histolytica galactose-adherence lectin promotes interleukin-12 gene transcription and protein production in human macrophages. European Journal of Immunology, 30, 423–430.
Castro, J., Vazquez-Iglesias, J. L., & rnal-Monreal, F. (1983). Dysentery caused by Balantidium coli – report of two cases. Endoscopy, 15, 272–274.
CDC. (2017). Amebiasis. https://wwwnc.cdc.gov/travel/yellowbook/2018/infectious-diseases-related-to-travel/amebiasis. Accessed Feb 2017.
Devera, R., Requena, I., Velasquez, V., Castillo, H., Guevara, R., De, S. M., Marin, C., & Silva, M. (1999). Balantidiasis in a rural community from bolivar state, Venezuela. Boletín Chileno de Parasitología, 54, 7–12.
Diana, E. (2003). Intestinal parasitoses: A history of scientific progress and endemic disease in society. In D. Dionisio (Ed.), Atlas of intestinal infections in AIDS (Vol. 1, pp. 7–34). Milano: Springer-Verlag Italia.
Espinosa-Cantellano, M., & Martinez-Palomo, A. (2000). Pathogenesis of intestinal amebiasis: From molecules to disease. Clinical Microbiology Reviews, 13, 318–331.
Evangelopoulos, A., Spanakos, G., Patsoula, E., Vakalis, N., & Legakis, N. (2000). A nested, multiplex, PCR assay for the simultaneous detection and differentiation of Entamoeba histolytica and Entamoeba dispar in faeces. Annals of Tropical Medicine and Parasitology, 94, 233–240.
Garcia, L. S. (1999). Flagellates and ciliates. Clinics in Laboratory Medicine, 19, 621–638. vii.
Garcia, L. S., Shimizu, R. Y., & Bernard, C. N. (2000). Detection of Giardia lamblia, Entamoeba histolytica/Entamoeba dispar, and Cryptosporidium parvum antigens in human fecal specimens using the triage parasite panel enzyme immunoassay. Journal of Clinical Microbiology, 38, 3337–3340.
Hindsbo, O., Nielsen, C. V., Andreassen, J., Willingham, A. L., Bendixen, M., Nielsen, M. A., & Nielsen, N. O. (2000). Age-dependent occurrence of the intestinal ciliate Balantidium coli in pigs at a Danish research farm. Acta Veterinaria Scandinavica, 41, 79–83.
Johnson, J. A., & Clark, C. G. (2000). Cryptic genetic diversity in Dientamoeba fragilis. Journal of Clinical Microbiology, 38, 4653–4654.
Karuna, T., & Khadanga, S. (2014). A rare case of urinary balantidiasis in an elderly renal failure patient. Trop Parasitol, 4, 47–49.
Keene, W. E., Petitt, M. G., Allen, S., & McKerrow, J. H. (1986). The major neutral proteinase of Entamoeba histolytica. The Journal of Experimental Medicine, 163, 536–549.
Kelsall, B. L., & Ravdin, J. I. (1993). Degradation of human IgA by Entamoeba histolytica. The Journal of Infectious Diseases, 168, 1319–1322.
Knight, R. (1978). Giardiasis, isosporiasis and balantidiasis. Clinics in Gastroenterology, 7, 31–47.
Ladas, S. D., Savva, S., Frydas, A., Kaloviduris, A., Hatzioannou, J., & Raptis, S. (1989). Invasive balantidiasis presented as chronic colitis and lung involvement. Digestive Diseases and Sciences, 34, 1621–1623.
Laughlin, R. C., & Temesvari, L. A. (2005). Cellular and molecular mechanisms that underlie Entamoeba histolytica pathogenesis: Prospects for intervention. Expert Reviews in Molecular Medicine, 7, 1–19.
Leber, A. L., & Novak, S. M. (2005). Intestinal and urogenital parasites. In P. R. Murray, B. EJ, J. H. Jorgensen, M. A. Pfaller, & R. H. Yolken (Eds.), Manual of Clinical Microbiology (Vol. 133, pp. 1990–2007). Washington: ASM Press.
Leippe, M., Andra, J., Nickel, R., Tannich, E., & Muller-Eberhard, H. J. (1994). Amoebapores, a family of membranolytic peptides from cytoplasmic granules of Entamoeba histolytica: Isolation, primary structure, and pore formation in bacterial cytoplasmic membranes. Molecular Microbiology, 14, 895–904.
Lösch, F. (1875). Massenhafte entwicklung von amobën im dickdarm. Archiv für pathologische anatomie und physiologie und für klinsche medicin, von Rudolf Virchow, 65, 196–121. Ref Type: Journal (Full).
Maleky, F. (1998). Case report of Balantidium coli in human from south of Tehran, Iran. Indian Journal of Medical Sciences, 52, 201–202.
Morgado, P., Manna, D., & Singh, U. (2016). Recent advances in Entamoeba biology: RNA interference, drug discovery, and gut microbiome. F1000Res. 5:2578.
Nakauchi, K. (1999). The prevalence of Balantidium coli infection in fifty-six mammalian species. The Journal of Veterinary Medical Science, 61, 63–65.
Ong, S. J., Cheng, M. Y., Liu, K. H., & Horng, C. B. (1996). Use of the ProSpecT microplate enzyme immunoassay for the detection of pathogenic and non-pathogenic Entamoeba histolytica in faecal specimens. Transactions of the Royal Society of Tropical Medicine and Hygiene, 90, 248–249.
Petri, W. A., Jr., Chapman, M. D., Snodgrass, T., Mann, B. J., Broman, J., & Ravdin, J. I. (1989). Subunit structure of the galactose and N-acetyl-D-galactosamine-inhibitable adherence lectin of Entamoeba histolytica. The Journal of Biological Chemistry, 264, 3007–3012.
Pillai, D. R., Keystone, J. S., Sheppard, D. C., MacLean, J. D., MacPherson, D. W., & Kain, K. C. (1999). Entamoeba histolytica and Entamoeba dispar: Epidemiology and comparison of diagnostic methods in a setting of nonendemicity. Clinical Infectious Diseases, 29, 1315–1318.
Ramirez, M. E., Perez, D. G., Nader, E., & Gomez, C. (2005). Entamoeba histolytica: Functional characterization of the −234 to −196 bp promoter region of the multidrug resistance EhPgp1 gene. Experimental Parasitology, 110, 238–243.
Rivera, W. L., Tachibana, H., Silva-Tahat, M. R., Uemura, H., & Kanbara, H. (1996). Differentiation of Entamoeba histolytica and E. Dispar DNA from cysts present in stool specimens by polymerase chain reaction: Its field application in the Philippines. Parasitology Research, 82, 585–589.
Rosenberg, I., Bach, D., Loew, L. M., & Gitler, C. (1989). Isolation, characterization and partial purification of a transferable membrane channel (amoebapore) produced by Entamoeba Histolytica. Molecular and Biochemical Parasitology, 33, 237–247.
Roy, S., Kabir, M., Mondal, D., Ali, I. K., Petri, W. A., Jr., & Haque, R. (2005). Real-time-PCR assay for diagnosis of Entamoeba histolytica infection. Journal of Clinical Microbiology, 43, 2168–2172.
Sanuki, J., Asai, T., Okuzawa, E., Kobayashi, S., & Takeuchi, T. (1997). Identification of Entamoeba Histolytica and E. Dispar cysts in stool by polymerase chain reaction. Parasitology Research, 83, 96–98.
Sargeaunt, P. G., Williams, J. E., & Grene, J. D. (1978). The differentiation of invasive and non-invasive Entamoeba histolytica by isoenzyme electrophoresis. Trans R Soc Trop Med Hyg. 72(5), 519–521.
Seijo, M. M., Gonzalez-Mediero, G., Santiago, P., Rodriguez De, L. A., Diz, J., Conde, C., & Visvesvara, G. S. (2000). Granulomatous amebic encephalitis in a patient with AIDS: Isolation of acanthamoeba sp. group II from brain tissue and successful treatment with sulfadiazine and fluconazole. Journal of Clinical Microbiology, 38, 3892–3895.
Solaymani-Mohammadi, S., Rezaian, M., Hooshyar, H., Mowlavi, G. R., Babaei, Z., & Anwar, M. A. (2004). Intestinal protozoa in wild boars (Sus Scrofa) in western Iran. Journal of Wildlife Diseases, 40, 801–803.
Vasilakopoulou, A., Dimarongona, K., Samakovli, A., Papadimitris, K., & Avlami, A. (2003). Balantidium coli pneumonia in an immunocompromised patient. Scandinavian Journal of Infectious Diseases, 35, 144–146.
Walderich, B., Weber, A., & Knobloch, J. (1997). Differentiation of Entamoeba histolytica and Entamoeba dispar from German travelers and residents of endemic areas. The American Journal of Tropical Medicine and Hygiene, 57, 70–74.
Weng, Y. B., Hu, Y. J., Li, Y., Li, B. S., Lin, R. Q., Xie, D. H., Gasser, R. B., & Zhu, X. Q. (2005). Survey of intestinal parasites in pigs from intensive farms in Guangdong Province, People's Republic of China. Veterinary Parasitology, 127, 333–336.
Ximénez, C., Cerritos, R., Rojas, L., Dolabella, S., Morán, P., Shibayama, M., González, E., Valadez, A., Hernández, E., Valenzuela, O., Limón, A., Partida, O., & Silva, E. F. (2010). Human amebiasis: breaking the paradigm? Int J Environ Res Public Health, 7(3), 1105–1120.
Zaki, M., & Clark, C. G. (2001). Isolation and characterization of polymorphic DNA from Entamoeba Histolytica. Journal of Clinical Microbiology, 39, 897–905.
Zhang, Z., Wang, L., Seydel, K. B., Li, E., Ankri, S., Mirelman, D., & Stanley, S. L., Jr. (2000). Entamoeba histolytica cysteine proteinases with interleukin-1 beta converting enzyme (ICE) activity cause intestinal inflammation and tissue damage in amoebiasis. Molecular Microbiology, 37, 542–548.
Zindrou, S., Orozco, E., Linder, E., Tellez, A., & Bjorkman, A. (2001). Specific detection of Entamoeba Histolytica DNA by hemolysin gene targeted PCR. Acta Tropica, 78, 117–125.
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Ortega, Y.R., Verastegui, M. (2018). Amoeba and Ciliates. In: Ortega, Y., Sterling, C. (eds) Foodborne Parasites. Food Microbiology and Food Safety(). Springer, Cham. https://doi.org/10.1007/978-3-319-67664-7_1
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DOI: https://doi.org/10.1007/978-3-319-67664-7_1
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