Skip to main content
SpringerLink
Log in
Book cover

Comprehensive Clinical Plasma Medicine pp 163–183Cite as

Cold Atmospheric Plasma (CAP) Combined with Chemo-Radiation and Cytoreductive Surgery: The First Clinical Experience for Stage IV Metastatic Colon Cancer

  • Chapter
  • First Online:

Abstract

The authors report the first clinical experience using CAP for Stage IV metastatic colon cancer. The report describes the patient’s history, chemotherapy, radiation, surgical treatment and ex-vivo and intra-operative treatment of the tumor and normal tissue with CAP. Evaluation of intra-operative temperature, oxygen and end tidal CO2 measurements during the surgery and post-surgery analysis of tissue treated by cold plasma. In vivo studies suggest that TRAIl-R1 expression increases in the CAP treated liver tissues, suggesting that the death receptor molecule may be involved in inducing apoptosis. Three-month postoperative CT scan of the abdomen and pelvis revealed no evidence of recurrent tumor at the resected and cold plasma treatment sites.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62:10–29.

    Article  Google Scholar 

  2. Chu DZ, Lang NP, Thompson C, Osteen PK, Westbrook KC. Peritoneal Carcinomatosis in non gynecologic malignancy. Cancer. 1989;63:364–7.

    Article  CAS  Google Scholar 

  3. Sadeghi B, Arvieux C, Glehen O, et al. Peritoneal carcinomatosis from non-gynecologic Smalignancies. Results from the EVOCAPE 1 multicentric prospective study. Cancer. 2000;88:358–63.

    Article  CAS  Google Scholar 

  4. Glehen O, Osinky D, Cotte E, Kwiatkowski F, Freyer G, Issac S, Trillet-lenoir V, Sayag-beaujard AC, Francois Y, Vignal J, et al. Intraperitoneal chemohyperthermia using a closed abdominal procedure and cytoreductive surgery for the treatment of peritoneal carcinomatosis: morbidity and mortality analysis of 216 concsecutive procedures. Ann Surg Oncol. 2003;10(8):863–9.

    Article  CAS  Google Scholar 

  5. Glockzin G, Rochon J, Arnold D, Sa L, Klebl F, Zeman F, Koller M, Schlitt HJ, Piso P. A prospective multicenter phase II study evaluating multimodality treatment of patients with peritoneal carcinomatosis arising from appendiceal and colorectal cancer: the combatac trial. BMC Cancer. 2013;13:67. https://doi.org/10.1186/1471-2407-13-67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Jayne DG, Fook S, Loi C, Seow-Choen F. Peritoneal carcinomatosis from colorectal cancer. Br J Surg. 2002;89:1545–50.

    Article  CAS  Google Scholar 

  7. Piso P, Arnold D. Multimodal treatment approaches for peritoneal carcinosis in colorectal cancer. Dtsch Arztebl Int. 2011;108(47):802–8.

    PubMed  PubMed Central  Google Scholar 

  8. Kulu Y, Muller-stich B, Buchler MW, Ulrich A. Surgical treatment of peritoneal carcinomatosis: current treatment modalities. Langenbeck's Arch Surg. 2013;399(1):41–53.

    Article  Google Scholar 

  9. Franko J, Shi Q, Goldman CD, et al. Treatment of Colorectal peritoneal carcinomatosis with systemic chemotherapy: a pooled analysis of north central cancer treatment group phase III trials n9741 and n9841. J Clin Oncol. 2012;30:263–7. https://doi.org/10.1016/ejso2013.06.001.

    Article  PubMed  Google Scholar 

  10. Verwaal VJ, van Ruth S, de Bree E, et al. Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer. J Clin Oncol. 2003;21:3737–43.

    Article  Google Scholar 

  11. Riss S, Mohamed F, Dayal S, Cecil T, Stift A, Bachleitner-Hofmann T, Moran B. Peritoneal Metasases from colorectal cancer: patient selection for cytoreductive surgery and Hyperthermic Intraperitoneal chemotherapy. Eur J Surg Oncol. 2013;39(9):931–7.

    Article  CAS  Google Scholar 

  12. Elias D, Gilly F, Quenet F, et al. Peritoneal colorectal carcinomatosis treated with surgery and Perioperative Intraperitoneal Chemotherapy: Retrospective analysis of 523 patients from a multicentric French study. J Clin Oncol. 2010;28:63–8.

    Article  Google Scholar 

  13. Laroussi M, Kong M, Morfill G, Stolz W, editors. Plasma medicine. Cambridge; 2012.

    Google Scholar 

  14. Friedman A, Friedman G. Plasma medicine. Hoboken: Wiley; 2013.

    Google Scholar 

  15. Keidar M, Beilis II. Plasma Engineering: application in aerospace, nanotechnology and bionanotechnology. Oxford: Elsevier; 2013.

    Google Scholar 

  16. Morfill GE, Kong MG, Zimmermann JL. Focus on plasma medicine. Review. New J Phys. 2009;11:115011.

    Article  Google Scholar 

  17. Keidar M. Plasma for cancer treatment. Plasma Source Sci Technol. 2015;24:033001.

    Article  Google Scholar 

  18. Fridman G, Friedman G, Gutsol A, Shekhter AB, Vasilets VN, Fridman A. Applied plasma medicine. Plasma Process Polym. 2008;5:503.

    Article  CAS  Google Scholar 

  19. Vandamme M, Robert E, Pesnel S, Barbosa E, Dozias S, Sobilo J, Lerondel S, Le Pape A, Pouvesle JM. Antitumor effect of plasma treatment on U87 Glioma Xenografts: preliminary results. Plasma Process Polym. 2010;7:264.

    Article  CAS  Google Scholar 

  20. Keidar M, Walk R, Shashurin A, Srinivasan P, Sandler A, Dasgupta S, Ravi R, Guerrero-Preston R, Trink B. Cold plasma selectivity and the possibility of a paradigm shift in cancer therapy. Br J Cancer. 2011;105:1295.

    Article  CAS  Google Scholar 

  21. Vandamme M, Robert E, Lerondel S, Sarron V, Ries D, Dozias S, Sobilo J, Gosset D, Kieda C, Legrain B, Pouvesle J-M, Le Pape A. ROS implication in a new antitumor strategy based on non-thermal plasma. Int J Cancer. 2011;130:2185.

    Article  Google Scholar 

  22. Metelmann HR. What kind of impact is possible by plasma-jet in head and neck cancer?”, The 2nd International Workshop on Plasma for Cancer Treatment, Nagoya, Japan, March, 2015.

    Google Scholar 

  23. Canady J. “Development and clinical application of hybrid and cold atmospheric plasma combined with systemic chemotherapy and selective 3D conformal radiation therapy: A novel approach to the treatment of peritoneal metastases from colorectal cancer.” The 2nd International Workshop on Plasma for Cancer Treatment, Nagoya, Japan, March, 2015.

    Google Scholar 

  24. Metelmann HR, Nedrelow DS, Seebauer C, Schuster M, von Woedtke T, Weltmann K-D, Kindler S, Metelmann PH, Finkelstein SE, Von Hoff DD, Podmelle F. Head and neck cancer treatment and physical plasma. Clin Plasma Med. 2015;3:17–23.

    Article  Google Scholar 

  25. Lahiri BB, Bagavathiappan S, Jayakumar T, Philip J. Medical applications of infrared thermography: a review. Infrared Phys Technol. 2012;55(4):221–35.

    Article  Google Scholar 

  26. Ray S, et al. Establishment of human ultra-low passage colorectal cancer cell lines using spheroids from fresh surgical specimens suitable for in vitro and in vivo studies. J Cancer. 2012;3:196–206.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Jerome Canady Research Institute for Advanced Biological and Technological Sciences, Translational and Molecular Center, Takoma Park, MD, USA

    Jerome Canady M.D., Warren Rowe Ph.D., Alexey Shashurin Ph.D., Sterlyn Jones, Kimberly Wiley M.D., Giacomo Basadonna M.D., Ph.D., Robert Dewitty M.D. & Michael Keidar Ph.D.

  2. Plasma Medicine Life Sciences, Takoma Park, MD, USA

    Jerome Canady M.D., Taisen Zhuang Ph.D., Shruti Wigh & Dereck Chiu

  3. Department of Mechanical and Aerospace Engineering, School of Engineering and Applied Science, The George Washington University, Washington, DC, USA

    Jerome Canady M.D.

  4. Department of Surgery, Baton Rouge General Hospital (Bluebonnet), Baton Rouge, LA, USA

    Steven Gordon M.D.

  5. George Washington University, Washington, DC, USA

    Alexey Shashurin Ph.D. & Michael Keidar Ph.D.

  6. Department of Radiology, Washington Hospital Center, Washington, DC, USA

    Emil Cohen M.D.

  7. Department of Pathology and Surgery, Howard University Hospital, Washington, DC, USA

    Tammy Naab M.D. & Robert Dewitty M.D.

  8. Department of Otolaryngology, Rambam Medical Center, Haifa, Israel

    Barry Trink Ph.D.

  9. Medical Oncology Section, Cancer for Center and Blood Disorder, Bethesda, MD, USA

    Victor Priego M.D.

  10. Cancer Center @ Gaithersburg, Radiation Oncology, Gaithersburg, MD, USA

    Anu Gupta M.D.

  11. Department of Surgery, University of Massachusetts School of Medicine, Worcester, MA, USA

    Giacomo Basadonna M.D., Ph.D.

Authors
  1. Jerome Canady M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Steven Gordon M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Taisen Zhuang Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shruti Wigh
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Warren Rowe Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Alexey Shashurin Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Dereck Chiu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Sterlyn Jones
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Kimberly Wiley M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Emil Cohen M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Tammy Naab M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Barry Trink Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Victor Priego M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Anu Gupta M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. Giacomo Basadonna M.D., Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. Robert Dewitty M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. Michael Keidar Ph.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jerome Canady M.D. .

Editor information

Editors and Affiliations

  1. University Medicine Greifswald, Department of Oral and Maxillofacial Surgery/Plastic Surgery, Greifswald, Germany

    Hans-Robert Metelmann

  2. Leibniz Institute for Plasma Science and Technology (INP Greifswald) and University Medicine Greifswald Institute for Hygiene and Environmental Medicine, Greifswald, Germany

    Thomas von Woedtke

  3. Leibniz Institute for Plasma Science and Technology (INP Greifswald), Greifswald, Germany

    Klaus-Dieter Weltmann

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG, part of Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Canady, J. et al. (2018). Cold Atmospheric Plasma (CAP) Combined with Chemo-Radiation and Cytoreductive Surgery: The First Clinical Experience for Stage IV Metastatic Colon Cancer. In: Metelmann, HR., von Woedtke, T., Weltmann, KD. (eds) Comprehensive Clinical Plasma Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-67627-2_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-67627-2_9

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-67626-5

  • Online ISBN: 978-3-319-67627-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation