Abstract
In this chapter we introduce the relevance of CAP for infection treatment and the role of this new tool in the management of multiresistant pathogens. Cap can be used for decolonization of patients e.g. with multiresistant Staphylococci (MRSA), enterococci (VRE) and gramnegative rods like ESBL-coli therewith demonstrating a role beside conventional antiseptics. It can be shown how CAP efficacy is related to the pathogen’s drug susceptibility and depends on gram stain behavior. Additionally, despite principal suitability killing all kind of tested pathogens that can be found in patients so far, clear differences in CAP efficacy towards different species can be elucidated and also significantly depending on the device type. To compare CAP devices testing susceptibility of a set of important pathogens is recommended, comparing also time and distance for successful treatment in vitro. The different test options are discussed in comparison with conventional drug susceptibility test methods (agar diffusion, bouillon dilution). Options and limitations of CAP application are presented to understand what we can await from practical use and where conventional treatment still is justified.
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Daeschlein, G. (2018). Antimicrobial Activity of Plasma. In: Metelmann, HR., von Woedtke, T., Weltmann, KD. (eds) Comprehensive Clinical Plasma Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-67627-2_6
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