Key Roles of Reactive Oxygen and Nitrogen Species

  • David B. Graves
  • Georg Bauer


Reactive oxygen and nitrogen species (RONS) are formed in biologically significant quantities whenever cold atmospheric pressure plasma is established in or near air. RONS enter adjacent aqueous liquid solutions readily and can strongly affect cells and tissue, mainly through their influence on redox (‘oxidation-reduction’) biological processes. Understanding and controlling these interactions is essential to plasma biomedical interactions. Plasma biomedicine is therefore significantly based on the complex and multiple properties of free radicals and other reactive species in a biological context. This chapter briefly summarizes some of the key emerging concepts of RONS in plasma biomedicine as well as some of the classic references regarding the roles of RONS in aerobic biology and medicine.


Cold atmospheric pressure plasma Reactive oxygen and nitrogen species Redox biology Oxidative cancer therapy 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Chemical and Biomolecular EngineeringUniversity of CaliforniaBerkeleyUSA
  2. 2.Institute of Virology, Medical Center and Faculty of MedicineUniversity of FreiburgFreiburgGermany

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