Perspectives in Immunology of Wound Healing

  • Kai Masur
  • Sander Bekeschus


Cold plasmas are partially ionised gases at low temperatures containing biologically active components—mostly reactive oxygen species (ROS), which also play an essential role in natural processes such as immune defence. Furthermore, those plasma generated ROS act commonly with other plasma components such as UV radiation, mild heat and electrical fields. Cold plasmas influence the cellular redox balance and can be adjusted depending on composition and treatment time so that cells are either stimulated or harmed. However, the sensitivities of the treated cells differ greatly from one another—which is dependent on different antioxidative potentials of the different cell types, as well as their ability to regenerate. Cold plasmas are useful for killing bacteria—multiresistant pathogens as well as non-resistant strains. It has been shown that a balanced plasma treatment of human cells can also lead to their stimulation. Therefore, a well-adjusted plasma composition can mediate an improved microenvironment by generating bactericidal conditions as well as positively influencing microcirculation of the plasma treated tissues. Furthermore, cold plasma treatment promotes an increased oxygen saturation and an improved supply with nutrition. Therefore, cold plasmas are useful to support wound healing by accelerating cell proliferation and triggering immune processes. This chapter will discuss the parallels between immune system responses and the effects of cold atmospheric pressure plasmas on cells and tissues.


Cold plasma Reactive oxygen species Wound healing Oxidative burst 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Associated Research Group “Plasma Wound Healing”Centre for Innovation Competence (ZIK) PlasmatisGreifswaldGermany
  2. 2.Young Research Group “Plasma Redox Effects”Centre for Innovation Competence (ZIK) PlasmatisGreifswaldGermany

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