Selected Settings of Clinical Plasma Treatment

  • T. Urayama
  • M. McGovern


This chapter introduces the Adtec MicroPlaSter and SteriPlas argon microwave plasma medical devices. The chapter covers the initial scientific research and general uses of plasma, first use in treatment of chronic wounds and a summary of the clinical evidence gathered in the clinical trials and post-market clinical studies.

Adtec has been actively involved in plasma research for over 15 years and the first plasma medical device to be used in clinical trials (MicroPlaSter beta) was developed in collaboration with the Max Planck Institute in Germany. This chapter includes information on the initial phase 1 and 2 clinical trials and the post-market clinical evidence gathered. The clinical evidence includes efficacy in microbial load reduction in chronic wounds, efficacy in treatment of surgical site infections and treatment of dermatological conditions such as Actinic Keratoses, Herpes Zoster and Hailey-Hailey disease. Over 10 years of clinical data has been gathered proving the clinical efficacy and safety of the microwave argon gas plasma technology used in the MicroPlaSter and SteriPlas products.


MicroPlaster SteriPlas Clinical trials Chronic wounds Surgical site infections Actinic keratoses Herpes zoster 



In writing this special issue, I would like to thank the Max—Planck Institute for Extraterrestrial Physics, Prof. G. Morfill, Dr. T. Shimizu, who collaborated on the research, and everyone else in the team.


  1. 1.
    Shindo H, et al. High density plasma applied process technology: Realize Co. Ltd; 1993.Google Scholar
  2. 2.
    Jimbo Y, Kitamura Y, Kusaba K, Kikuchi M, Shindo H. Mode transition enhancement by permittivity of window materials in low frequency plasmas. Appl Phys Exp. 2009;2:016001.CrossRefGoogle Scholar
  3. 3.
    Ishihara D, Noma T, Sai M, Stauss S, Tomai T, Terashima K. Development of a dielectric barrier discharge (DBD) cryo-microplasma: generation and diagnostics. Plasma Source Sci Technol. 2008;17:035008.CrossRefGoogle Scholar
  4. 4.
    Ichiki T, Koidesawa T, Horiike Y. An atmospheric-pressure microplasma jet source for the optical emission spectroscopic analysis of liquid sample. Plasma Source Sci Technol. 2003;12:S16.CrossRefGoogle Scholar
  5. 5.
    Akitsu T, et al. Micro/nano plasma technology and its applications. Frankfurt: CMC; 2006.Google Scholar
  6. 6.
  7. 7.
    Shimizu T, Steffes B, Pompl R, Jamitzky F, Bunk W, Morfill GE, Ramrath K, Georgi M, Stolz W, Schmidt H-U, Urayama T, Fujii S. Characterization of microwave plasma torch for decontamination. Plasma Process Polym. 2008;5:577–82. Scholar
  8. 8.
    Sato T, Miyahara T, Doi A, Ochiai S, Urayama T, Nakatani T. Sterilization mechanism for Escherichia Coli by plasma flow at atmospheric pressure. Appl Phys Lett. 2006;89:73902.CrossRefGoogle Scholar
  9. 9.
    Sato T, Fujioka K, Ramasamy R, Urayama T, Fujii S. Sterilization efficacy of a coaxial microwave plasma flow at atmospheric pressure. IEEE Trans Ind Appl. 2006;42:399–404.CrossRefGoogle Scholar
  10. 10.
    Sato T, Doi A, Urayama T, Nakatani T, Miyahara T. Inactivation of Escherichia Coli by a coaxial microwave plasma flow. IEEE Trans Ind Appl. 2007;43:1159–63.CrossRefGoogle Scholar
  11. 11.
  12. 12.
  13. 13.
  14. 14.
    Top five treatment costs of skin diseases. American Academy of Dermatology Report 2005. Prepared by the Lewin Group.Google Scholar
  15. 15.
    Maisch T, Bosserhoff AK, Unger P, Heider J, Shimizu T, Zimmermann JL, Morfill GE, Landthaler M, Karrer S. Investigation of toxicity and mutagenicity of cold atmospheric argon plasma. Environ Mol Mutagen. 2017;58(3):172–7.CrossRefGoogle Scholar
  16. 16.
    Isbary G, Heinlin J, Shimizu T, Zimmermann JL, Morfill G, Schmidt H-U, Monetti R, Steffes B, Bunk W, Li Y, Klaempfl T, Karrer S, Landthaler M, Stolz W. Successful and safe use of 2 min cold atmospheric argon plasma in chronic wounds: results of a randomized controlled trial. Br J Dermatol. 2012;167(2):404–10.CrossRefGoogle Scholar
  17. 17.
    Ermolaeva SA, Varfolomeev AF, Yu M, Chernukha DS, Yurov MM, Vasiliev AA, Kaminskaya MMM, Romanova JM, Murashev AN, Selezneva II, Shimizu T, Sysolyatina EV, Shaginyan IA, Petrov OF, Mayevsky EI, Fortov VE, Morfill GE, Naroditsky BS, Gintsburg AL. Bactericidal effects of non-thermal argon plasma in vitro, in biofilms and in the animal model of infected wounds. J Med Microbiol. 2011;60:75–83.CrossRefGoogle Scholar
  18. 18.
    Booth R. Wounds UK 2015. Antibiofilm activity demonstrated following treatment with a novel plasma device (Poster presentation).Google Scholar
  19. 19.
    Westgate S. EWMA 2016. Antibiofilm activity demonstrated following treatment with a novel plasma device. Bremen (Poster presentation).Google Scholar
  20. 20.
    Rotering H. EWMA 2016. Cold atmospheric plasma- new options for infection control in wound management. Bremen (Oral presentation).Google Scholar
  21. 21.
    Rotering H. WUWHS 2016 cold atmospheric plasma- new treatment options for infected chronic implants. Florence (Oral presentation).Google Scholar
  22. 22.
    Isbary G, Morfill GE, Schmidt H-U, Georgi M, Ramrath K, Heinlin J, Karrer S, Landthaler M, Shimizu T, Steffes B, Bunk W, Monetti R, Zimmermann JL, Pompl R, Stolz W. A first prospective randomized controlled trial to decrease bacterial load using cold atmospheric argon plasma on chronic wounds in patients. Br J Dermatol. 2010;163(1):78–82.PubMedPubMedCentralGoogle Scholar
  23. 23.
    Arndt S, Unger P, Wacker E, Shimizu T, Heinlin J, Li Y-F, Hubertus T, Morfill GE, Zimmermann JL, Bosserhoff A-K, Karrer S. Cold Atmospheric plasma (CAP) Changes gene expression of key molecules of the wound healing machinery and improves wound healing in vitro and in vivo. PLoS One. 2013;8(11):e79325.CrossRefGoogle Scholar
  24. 24.
    Shimizu T, Nosenko T, Morfill GE, Sato T, Schmidt H-U, Urayama T. Characterization of low-temperature microwave plasma treatment with and without UV light for disinfection. Plasma Process Polym. 2010;7:288–93.CrossRefGoogle Scholar
  25. 25.
    Arndt S, Landthaler M, Zimmemann JL, Unger P, Wacker E, Shimizu T, Li YF, Morfill GE, Bosserhoff AK, Karrer S. Effects of cold atmospheric plasma (CAP) on ß-defensins, inflammatory cytokines, and apoptosis-related molecules in keratinocytes in vitro and in vivo. PLoS One. 2015;10(3):e0120041.CrossRefGoogle Scholar
  26. 26.
    Heinlin J, Zimmermann JL, Zeman F, Bunk W, Isbary G, Landthaler M, Maisch T, Monetti R, Morfill GE, Shimizu T, Steinbauer J, Stolz W, Karrer S. Randomized placebo-controlled human pilot study of cold atmospheric argon plasma on skin graft donor sites. Wound Repair Reg. 2013;21(6):800–7.CrossRefGoogle Scholar
  27. 27.
    Isbary G, Stolz W, Shimizu T, Monetti R, Bunk W, Schmidt H-U, Morfill GE, Klaempfl TG, Steffes B, Thomas HM, Heinlin J, Karrer S, Landthaler M, Zimmermann JL. Cold atmospheric argon plasma treatment may accelerate wound healing in chronic wounds: results of a retrospective in vivo randomized controlled study. Clin Plasma Med. 2013;1(2):25–30.CrossRefGoogle Scholar
  28. 28.
    Isbary G, Morfill G, Zimmermann J, Shimizu T, Stolz W. Cold atmospheric plasma: a successful treatment of lesions in Hailey-Hailey disease. Arch Dermatol. 2011;147(4):388–90.CrossRefGoogle Scholar
  29. 29.
    Isbary G, Shimizu T, Zimmermann J, Hubertus T, Morfill G, Stolz W. Cold atmospheric plasma for local infection control and subsequent pain reduction in a patient with chronic post operative ear infection. New Microbes New Infect. 2013;1(3):41–3.CrossRefGoogle Scholar
  30. 30.
    Isbary G, Shimizu T, Zimmermann JL, Heinlin J, Al-Zaabi S, Rechfeld M, Morfill GE, Karrer S, Stolz W. Randomized placebo-controlled clinical trial showed cold atmospheric argon plasma relieved acute pain and accelerated healing in herpes zoster. Clin Plasma Med. 2014;2(2):50–5.CrossRefGoogle Scholar
  31. 31.
    Kwang CL. Wounds UK 2015. Use of cold atmospheric plasma treatment in a chronic burn wound (Poster presentation).Google Scholar
  32. 32.
    Wirtz M, Stoffels I, Dissemond J, Schadendorf D, Roesch A. Actinic keratoses treated with cold atmospheric plasma. J Eur Acad Dermatol Venereol. 2018;32(1):e37–9. Scholar
  33. 33.
    Potera C. Antibiotic Resistance: biofilm dispersing agent rejuvenates older antibiotics. Environ Health Perspect. 2010;118(7):A288.CrossRefGoogle Scholar
  34. 34.
    Ousey K, Fumarola S, Cook L, Bianchi J. The Missing Link: the key to improved wound assessment. Case Study. Br J Nurs. London. 2012.
  35. 35.
    Heyman H, Van De Looverbosch DE, Meijer EP, Schols JM. Benefits of an oral nutritional supplement on pressure ulcer healing in long-term care residents. J Wound Care. 2008;17:476–8.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.ADTEC Europe LimitedMiddlesexUK
  2. 2.Adtec Europe LtdHounslowUK

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