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TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease pp 137–148Cite as

Role and Fate of TCTP in Protein Degradative Pathways

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Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 64))

Abstract

This chapter focuses on published studies specifically concerning TCTP and its involvement in degradation or stabilization of various proteins, and also in its own degradation in different ways. The first part relates to the inhibition of proteasomal degradation of proteins. This can be achieved by masking ubiquitination sites of specific partners, by favoring ubiquitin E3 ligase degradation, or by regulating proteasome activity. The second part addresses the ability of TCTP to favor degradation of specific proteins through proteasome or macroautophagic pathways. The third part discusses about the different ways by which TCTP has been shown to be degraded.

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Abbreviations

Bre5:

Brefeldin A sensitivity 5

CMA:

Chaperone-mediated autophagy

DHA:

Dihydroartemisinin

HIF1α:

Hypoxia-inducible factor 1α

HRF:

Histamine releasing factor

Hsp27:

Heat shock protein 27

Mcl-1:

Myeloid cell leukemia 1

Mdm2:

Murine double minute 2

Mmi1:

Microtubule and mitochondria interacting protein

Mss4:

Mammalian suppressor of yeast Sec4

Mst-1:

Mammalian sterile twenty-1

NTHK1:

Tobacco histidine kinase-1

Pim-3:

Serine/threonine-protein kinase Pim-3

PRX1:

Peroxiredoxin-1

Rpn:

26S proteasome regulatory subunit

Rpt:

Proteasome regulatory particle base subunit

UPS:

Ubiquitin–proteasome system

TCTP:

Translationally controlled tumor protein

Ubp3:

ubiquitin specific protease 3

VHL:

von Hippel–Lindau protein

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Acknowledgements

This work was supported by grants from the CNRS, the University of Montpellier, and from the Labex LERMIT.

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Authors and Affiliations

  1. Université Montpellier, UMR 5235, cc107, 34095, Montpellier, France

    Michel Vidal

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  1. Michel Vidal
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Correspondence to Michel Vidal .

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  1. Bâtiment B2M, Institut Gustave Roussy, Villejuif, Val-de-Marne, France

    Adam Telerman

  2. Bâtiment B2M, Institut Gustave Roussy, Villejuif, Val-de-Marne, France

    Robert Amson

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Vidal, M. (2017). Role and Fate of TCTP in Protein Degradative Pathways. In: Telerman, A., Amson, R. (eds) TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease. Results and Problems in Cell Differentiation, vol 64. Springer, Cham. https://doi.org/10.1007/978-3-319-67591-6_6

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