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Introduction: How We Encountered TCTP and Our Purpose in Studying It

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TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 64))

Abstract

In this brief introduction, we describe our encounter with TCTP. Back in 2000, we discovered TCTP in two quite different ways: first, we looked at protein partners of TSAP6 and one of them was TCTP. Then, in collaboration with Sidney Brenner, we performed a high-throughput differential screening comparing the parental cancer cells with revertants. The results indicated that TCTP was of the most differentially expressed genes. These two approaches were carried out only months apart. They guided our research and led to the discoveries of drugs that inhibit the function of TCTP. Much of the preclinical data on sertraline as an inhibitor of TCTP in cancer were obtained with Judith Karp at Johns Hopkins. This drug is now given in combination with Ara-C to patients in a phase I clinical trial for Acute Myeloid Leukemia. We will here detail how all this happened in our lab while working around one central project: tumor reversion.

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Acknowledgements

This work was supported by grants from the French National Agency for Research (ANR, ANR-09-BLAN-0292) to AT, RA, and MV; European Union Network of Excellence CONTICANET to AT and RA; LabEx LERMIT to AT and RA; INCa Projets libres de Recherche 2013-1-PL BIO-10 “Biologie et Sciences du Cancer” to AT and RA; Ligue Nationale Contre le Cancer to AT and RA; Odyssea fund to RA.

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  1. Bâtiment B2M, Institut Gustave Roussy, Unité Inserm U981, 114 rue Édouard-Vaillant, 94805, Villejuif, France

    Adam Telerman

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Correspondence to Adam Telerman .

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  1. Bâtiment B2M, Institut Gustave Roussy, Villejuif, Val-de-Marne, France

    Adam Telerman

  2. Bâtiment B2M, Institut Gustave Roussy, Villejuif, Val-de-Marne, France

    Robert Amson

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Telerman, A., Amson, R. (2017). Introduction: How We Encountered TCTP and Our Purpose in Studying It. In: Telerman, A., Amson, R. (eds) TCTP/tpt1 - Remodeling Signaling from Stem Cell to Disease. Results and Problems in Cell Differentiation, vol 64. Springer, Cham. https://doi.org/10.1007/978-3-319-67591-6_1

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