Skip to main content

Robust Regression of Brain Maturation from 3D Fetal Neurosonography Using CRNs

  • Conference paper
  • First Online:

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 10554))

Abstract

We propose a fully three-dimensional Convolutional Regression Network (CRN) for the task of predicting fetal brain maturation from 3D ultrasound (US) data. Anatomical development is modelled as the sonographic patterns visible in the brain at a given gestational age, which are aggregated by the model into a single value: the brain maturation (BM) score. These patterns are learned from 589 3D fetal volumes, and the model is applied to 3D US images of 146 fetal subjects acquired at multiple, ethnically diverse sites, spanning an age range of 18 to 36 gestational weeks. Achieving a mean error of 7.7 days between ground-truth and estimated maturational scores, our method outperforms the current state-of-art for automated BM estimation from 3D US images.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Notes

  1. 1.

    This result refers to the RRF model which exclusively used brain features, and did not incorporate information about fetal size (i.e. head circumference).

References

  1. Toi, A., Lister, W.S., Fong, K.W.: How early are fetal cerebral sulci visible at prenatal ultrasound and what is the normal pattern of early fetal sulcal development? Ultrasound Obstet. Gynecol. 24(7), 706–715 (2004)

    Article  Google Scholar 

  2. Monteagudo, A., Timor-Tritsch, I.E.: Normal sonographic development of the central nervous system from the second trimester onwards using 2D, 3D and transvaginal sonography. Prenat. Diagn. 29(4), 326–339 (2009)

    Article  Google Scholar 

  3. Vinkesteijn, A., Mulder, P., Wladimiroff, J.: Fetal transverse cerebellar diameter measurements in normal and reduced fetal growth. Ultrasound Obstet. Gynecol. 15(1), 47–51 (2000)

    Article  Google Scholar 

  4. Pistorius, L.R., Stoutenbeek, P., Groenendaal, F., de Vries, L., Manten, G., Mulder, E., Visser, G.: Grade and symmetry of normal fetal cortical development: a longitudinal two- and three-dimensional ultrasound study. Ultrasound Obstet. Gynecol. 36(6), 700–708 (2010)

    Article  Google Scholar 

  5. Franke, K., Luders, E., May, A., Wilke, M., Gaser, C.: Brain maturation: predicting individual BrainAGE in children and adolescents using structural MRI. NeuroImage 63(3), 1305–1312 (2012)

    Article  Google Scholar 

  6. Toews, M., Wells, W.M., Zöllei, L.: A feature-based developmental model of the infant brain in structural MRI. In: Ayache, N., Delingette, H., Golland, P., Mori, K. (eds.) MICCAI 2012. LNCS, vol. 7511, pp. 204–211. Springer, Heidelberg (2012). doi:10.1007/978-3-642-33418-4_26

    Chapter  Google Scholar 

  7. Namburete, A.I.L., Stebbing, R.V., Kemp, B., Yaqub, M., Papageorghiou, A.T., Alison Noble, J.: Learning-based prediction of gestational age from ultrasound images of the fetal brain. Med. Image Anal. 21(1), 72–86 (2015)

    Article  Google Scholar 

  8. Štern, D., Payer, C., Lepetit, V., Urschler, M.: Automated age estimation from hand MRI volumes using deep learning. In: Ourselin, S., Joskowicz, L., Sabuncu, M.R., Unal, G., Wells, W. (eds.) MICCAI 2016. LNCS, vol. 9901, pp. 194–202. Springer, Cham (2016). doi:10.1007/978-3-319-46723-8_23

    Chapter  Google Scholar 

  9. Huber, P.J.: Robust estimation of a location parameter. Ann. Math. Stat. 35(1), 73–101 (1964)

    Article  MathSciNet  MATH  Google Scholar 

  10. Papageorghiou, A.T., Ohuma, E.O., Altman, D.G., Todros, T., Cheikh Ismail, L., Lambert, A., Jaffer, Y.A., Bertino, E., Gravett, M.G., Purwar, M., Noble, J.A., Pang, R., Victora, C.G., Barros, F.C., Carvalho, M., Salomon, L.J., Bhutta, Z.A., Kennedy, S.H., Villar, J.: International fetal and newborn growth consortium for the 21st century (INTERGROWTH-21st): international standards for fetal growth based on serial ultrasound measurements: the Fetal growth longitudinal study of the INTERGROWTH-21st project. Lancet 384(9946), 869–79 (2014)

    Article  Google Scholar 

  11. Tieleman, T., Hinton, G.: Lecture 6.5-RMSprop: divide the gradient by a running average of its recent magnitude. COURSERA Neural Networks Mach. Learn. 4, 26–31 (2012)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ana I. L. Namburete .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this paper

Cite this paper

Namburete, A.I.L., Xie, W., Noble, J.A. (2017). Robust Regression of Brain Maturation from 3D Fetal Neurosonography Using CRNs. In: Cardoso, M., et al. Fetal, Infant and Ophthalmic Medical Image Analysis. OMIA FIFI 2017 2017. Lecture Notes in Computer Science(), vol 10554. Springer, Cham. https://doi.org/10.1007/978-3-319-67561-9_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-67561-9_8

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-67560-2

  • Online ISBN: 978-3-319-67561-9

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics