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Spatiotemporal Analysis of Structural Changes of the Lamina Cribrosa

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Fetal, Infant and Ophthalmic Medical Image Analysis (OMIA 2017, FIFI 2017)

Part of the book series: Lecture Notes in Computer Science ((LNIP,volume 10554))

Abstract

Glaucoma, a progressive and degenerative disease of the optic nerve, is the second leading cause of blindness worldwide. Mechanical deformation of the lamina cribrosa (LC) under high intraocular pressure (IOP) can lead to axonal death of optic nerve fibers. To explore the effect of pressure on the LC, we utilize an experimental setup where longitudinal 3D optical coherence tomography (OCT) images are acquired at different levels of IOP administered via a well-controlled external force. Structural changes are measured via image deformations which map all observed images simultaneously into a common coordinate space. These deformations encode local patterns of structural and volume change across the image sequence, resulting in quantification of the spatiotemporal deformation pattern of the LC due to variation of pressure. We also describe a 3D segmentation algorithm to restrict our deformation analysis separately to the beams or pores of the LC. A single case study demonstrates the potential of the proposed methodology for non-invasive in-vivo analysis of LC dynamics in individual subjects.

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Author information

Authors and Affiliations

  1. Tandon School of Engineering, New York University, Brooklyn, NY, USA

    Charly Girot, James Fishbaugh & Guido Gerig

  2. Langone Medical Center, Department of Ophtalmology, NYU School of Medicine, New York, NY, USA

    Hiroshi Ishikawa, Gadi Wollstein & Joel Schuman

Authors
  1. Charly Girot
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  2. Hiroshi Ishikawa
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  3. James Fishbaugh
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  4. Gadi Wollstein
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  5. Joel Schuman
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  6. Guido Gerig
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Corresponding author

Correspondence to James Fishbaugh .

Editor information

Editors and Affiliations

  1. University College London, London, United Kingdom

    M. Jorge Cardoso

  2. McGill University, Montreal, Canada

    Tal Arbel

  3. University College London, London, United Kingdom

    Andrew Melbourne

  4. Medical University of Vienna, Vienna, Austria

    Hrvoje Bogunovic

  5. Eindhoven University of Technology, Eindhoven, The Netherlands

    Pim Moeskops

  6. Soochow University, Suzhou, China

    Xinjian Chen

  7. Medical University of Vienna, Vienna, Austria

    Ernst Schwartz

  8. University of Iowa, Iowa City, Iowa, USA

    Mona Garvin

  9. Imperial College London, London, United Kingdom

    Emma Robinson

  10. University of Dundee, Dundee, United Kingdom

    Emanuele Trucco

  11. University College London, London, United Kingdom

    Michael Ebner

  12. A*STAR Institute for Infocomm Research, Singapore, Singapore

    Yanwu Xu

  13. Imperial College London, London, United Kingdom

    Antonios Makropoulos

  14. University College London, London, United Kingdom

    Adrien Desjardin

  15. University College London, London, United Kingdom

    Tom Vercauteren

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© 2017 Springer International Publishing AG

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Girot, C., Ishikawa, H., Fishbaugh, J., Wollstein, G., Schuman, J., Gerig, G. (2017). Spatiotemporal Analysis of Structural Changes of the Lamina Cribrosa. In: Cardoso, M., et al. Fetal, Infant and Ophthalmic Medical Image Analysis. OMIA FIFI 2017 2017. Lecture Notes in Computer Science(), vol 10554. Springer, Cham. https://doi.org/10.1007/978-3-319-67561-9_21

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  • DOI: https://doi.org/10.1007/978-3-319-67561-9_21

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-67560-2

  • Online ISBN: 978-3-319-67561-9

  • eBook Packages: Computer ScienceComputer Science (R0)

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