Abstract
Measuring the distribution of major brain tissues using magnetic resonance (MR) images has attracted extensive research efforts. Due to its remarkable success, deep learning-based image segmentation has been applied to this problem, in which the size of patches usually represents a tradeoff between complexity and accuracy. In this paper, we propose the multi-size-and-position neural network (MSPNN) for brain MR image segmentation. Our contributions include (1) jointly using U-Nets trained on large patches and back propagation neural networks (BPNNs) trained on small patches for segmentation, and (2) adopting the convolutional auto-encoder (CAE) to restore MR images before applying them to BPNNs. We have evaluated this algorithm against five widely used brain MR image segmentation approaches on both synthetic and real MR studies. Our results indicate that the proposed algorithm can segment brain MR images effectively and provide precise distribution of major brain tissues.
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Tohka, J., Krestyannikov, E., Dinov, I.D., Graham, A.M., Shattuck, D.W., Ruotsalainen, U., Toga, A.W.: Genetic algorithms for finite mixture model based voxel classification in neuroimaging. IEEE Trans. Med. Imaging 26(5), 696–711 (2007)
Zhang, T., Xia, Y., Feng, D.D.: Hidden Markov random field model based brain MR image segmentation using clonal selection algorithm and Markov chain Monte Carlo method. Biomed. Signal Process. Control 12(1), 10–18 (2014)
Tzikas, D.G., Likas, A.C., Galatsanos, N.P.: The variational approximation for Bayesian inference. IEEE Signal Process. Mag. 25(6), 131–146 (2008)
Dubey, Y.K., Mushrif, M.M., Mitra, K.: Segmentation of brain MR images using rough set based intuitionistic fuzzy clustering. Biocybern. Biomed. Eng. 36(2), 413–426 (2016)
Ouarda, A., Fadila, B.: Improvement of MR brain images segmentation based on interval type-2 fuzzy C-Means. In: Third World Conference on Complex Systems (2016)
Ji, Z., Xia, Y., Sun, Q., Chen, Q., Xia, D., Feng, D.D.: Fuzzy local Gaussian mixture model for brain MR image segmentation. IEEE Trans. Inf Technol. Biomed. 16(3), 339–347 (2012). A Publication of the IEEE Engineering in Medicine & Biology Society
Su, C.M., Chang, H.H.: A level set based deformable model for segmentation of human brain MR images. In: IEEE International Conference on Biomedical Engineering and Informatics, pp. 105–109 (2014)
Zhang, W., Li, R., Deng, H., Wang, L., Lin, W., Ji, S., Shen, D.: Deep convolutional neural networks for multi-modality isointense infant brain image segmentation. Neuroimage 108, 214–224 (2015)
Brébisson, A.D., Montana, G.: Deep neural networks for anatomical brain segmentation. In: Computer Vision and Pattern Recognition Workshops, pp. 20–28 (2015)
Moeskops, P., Viergever, M.A., Mendrik, A.M., Vries, L.S.D., Benders, M.J.N.L., Išgum, I.: Automatic segmentation of MR brain images with a convolutional neural network. IEEE Trans. Med. Imaging 35(5), 1252–1261 (2016)
Long, J., Shelhamer, E., Darrell, T.: Fully convolutional networks for semantic segmentation. In: IEEE Conference on Computer Vision and Pattern Recognition, pp. 1337–1342 (2015)
Nie, D., Wang, L., Gao, Y., Sken, D.: Fully convolutional networks for multi-modality isointense infant brain image segmentation. In: IEEE International Symposium on Biomedical Imaging, pp. 1342–1345 (2016)
Chen, H., Dou, Q., Yu, L., Qin, J., Heng, P.A.: VoxResNet: deep voxelwise residual networks for brain segmentation from 3D MR images. Neuroimage (2017)
Ronneberger, O., Fischer, P., Brox, T.: U-Net: convolutional networks for biomedical image segmentation. In: International Conference on Medical Image Computing and Computer-Assisted Intervention, pp. 234–241 (2015)
Rumelhart, D., Mcclelland, J.: Parallel Distributed Processing: Explorations in the Microstructure of Cognition: Foundations. MIT Press, Cambridge (1986)
Masci, J., Meier, U., Dan, C., Schmidhuber, J.: Stacked convolutional auto-encoders for hierarchical feature extraction. In: International Conference on Artificial Neural Networks, pp. 52–59 (2011)
Dale, A.M., Liu, A.K., Fischl, B.R., Buckner, R.L., Belliveau, J.W., Lewine, J.D., Halgren, E.: Dynamic statistical parametric mapping: combining fMRI and MEG for high-resolution imaging of cortical activity. Neuron 26(1), 55–67 (2000)
Smith, S.M., Jenkinson, M., Woolrich, M.W., Beckmann, C.F., Behrens, T.E.J., Johansen-Berg, H., Bannister, P.R., Luca, M.D., Drobnjak, I., Flitney, D.E.: Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 23(Suppl. 1), S208–S219 (2004)
Collins, D.L., Zijdenbos, A.P., Kollokian, V., Sled, J.G., Kabani, N., Holmes, C.J., Evans, A.C.: Design and construction of a realistic digital brain phantom. IEEE Trans. Med. Imaging 17(3), 463–468 (1998)
School, M.G.H.H.M.: The Internet Brain Segmentation Repository (IBSR). http://www.cma.mgh.harvard.edu/ibsr/index.html
Rohlfing, T.: Image similarity and tissue overlaps as surrogates for image registration accuracy: widely used but unreliable. IEEE Trans. Med. Imaging 31(2), 153–163 (2012)
Bharatha, A., Hirose, M., Hata, N., Warfield, S.K., Ferrant, M., Zou, K.H., Suarez-Santana, E., Ruiz-Alzola, J., Amico, A.D., Cormack, R.A.: Evaluation of three-dimensional finite element-based deformable registration of pre- and intra-operative prostate imaging. Med. Phys. 28(12), 2551–2560 (2001)
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This work was supported by the National Natural Science Foundation of China under Grants 61471297.
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Wei, J., Xia, Y. (2017). Multi-scale Networks for Segmentation of Brain Magnetic Resonance Images. In: Cardoso, M., et al. Deep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support . DLMIA ML-CDS 2017 2017. Lecture Notes in Computer Science(), vol 10553. Springer, Cham. https://doi.org/10.1007/978-3-319-67558-9_36
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DOI: https://doi.org/10.1007/978-3-319-67558-9_36
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