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Deep Multimodal Case–Based Retrieval for Large Histopathology Datasets

  • Oscar Jimenez-del-ToroEmail author
  • Sebastian Otálora
  • Manfredo Atzori
  • Henning Müller
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 10530)

Abstract

The current gold standard for interpreting patient tissue samples is the visual inspection of whole–slide histopathology images (WSIs) by pathologists. They generate a pathology report describing the main findings relevant for diagnosis and treatment planning. Searching for similar cases through repositories for differential diagnosis is often not done due to a lack of efficient strategies for medical case–based retrieval. A patch–based multimodal retrieval strategy that retrieves similar pathology cases from a large data set fusing both visual and text information is explained in this paper. By fine–tuning a deep convolutional neural network an automatic representation is obtained for the visual content of weakly annotated WSIs (using only a global cancer score and no manual annotations). The pathology text report is embedded into a category vector of the pathology terms also in a non–supervised approach. A publicly available data set of 267 prostate adenocarcinoma cases with their WSIs and corresponding pathology reports was used to train and evaluate each modality of the retrieval method. A MAP (Mean Average Precision) of 0.54 was obtained with the multimodal method in a previously unseen test set. The proposed retrieval system can help in differential diagnosis of tissue samples and during the training of pathologists, exploiting the large amount of pathology data already existing digital hospital repositories.

Notes

Acknowledgments

This work was partially supported by the Eurostars project E! 9653 SLDESUTO-BOX. The authors would like to thank pathologist Lis Vázquez for her counsel regarding the handling of the pathology reports.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Oscar Jimenez-del-Toro
    • 1
    • 2
    Email author
  • Sebastian Otálora
    • 1
    • 2
  • Manfredo Atzori
    • 1
  • Henning Müller
    • 1
    • 2
  1. 1.University of Geneva (UNIGE)GenevaSwitzerland
  2. 2.University of Applied Sciences Western Switzerland (HES-SO)SierreSwitzerland

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