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Retinal Prostheses: Other Therapies and Future Directions

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Retinal Prosthesis

Part of the book series: Essentials in Ophthalmology ((ESSENTIALS))

Abstract

Inherited and age-related retinal dystrophies, such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD), respectively, are a leading cause of irreversible vision loss. Various approaches aiming at restoring visual function in the blind are currently under development and evaluation: neuroprotection, gene and cell therapy, and retinal prostheses. In this review, we focus on recent advances in optogenetics and cell therapy, two therapeutic strategies that have the potential to restore vision in a broad spectrum of retinal degenerative diseases. We discuss major advantages of optogenetics and cell therapies as well as their current limitations.

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Authors and Affiliations

  1. Institut de la Vision, Sorbonne Universités, UPMC Univ Paris 6, INSERM UMRS_968, CNRS UMR 7210, Paris, France

    Olivier Goureau Ph.D., Antoine Chaffiol Ph.D., Gregory Gauvain Ph.D., Serge Picaud Ph.D., Jens Duebel Ph.D. & José-Alain Sahel M.D.

  2. Université Evry Val Essonne, ISTEM, Paris, France

    Christelle Monville Ph.D.

  3. Centre Hospitalier National d’Ophtalmologie des Quinze-Vingts, DHU Sight Restore, INSERM-DHOS CIC, Paris, France

    José-Alain Sahel M.D.

  4. Fondation Ophtalmologique Adolphe de Rothschild, Paris, France

    José-Alain Sahel M.D.

  5. Department of Ophthalmology, The University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA

    José-Alain Sahel M.D.

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  1. Olivier Goureau Ph.D.
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  2. Christelle Monville Ph.D.
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  3. Antoine Chaffiol Ph.D.
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Correspondence to Olivier Goureau Ph.D. or Jens Duebel Ph.D. .

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  1. Roski Eye Institute, Institute for Biomedical Therapeutics, University of Southern California, Los Angeles, California, USA

    Mark S. Humayun

  2. University of Washington Eye Institute, Seattle, Washington, USA

    Lisa C. Olmos de Koo

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Goureau, O. et al. (2018). Retinal Prostheses: Other Therapies and Future Directions. In: Humayun, M., Olmos de Koo, L. (eds) Retinal Prosthesis. Essentials in Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-319-67260-1_7

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  • Print ISBN: 978-3-319-67258-8

  • Online ISBN: 978-3-319-67260-1

  • eBook Packages: MedicineMedicine (R0)

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