Skip to main content

Abstract

The Doppler shift is a change in frequency that occurs when sound (or light) is emitted from, or bounced off of, a moving object. The role of Doppler ultrasound in thyroid imaging has recently experienced a significant change. The prior belief that power Doppler imaging plays an important role in the prediction of the likelihood of malignancy in a thyroid nodule has undergone a reassessment. Most of the prior guidelines for management of thyroid nodules considered vascularity as a risk factor for malignancy. More recent studies suggest that vascularity does not have a significant predictive value in most thyroid nodules. Most guidelines still recommend documentation of vascularity in all significant thyroid nodules but do not consider vascularity as a factor determining the need for biopsy. An absent flow pattern does not have sufficient predictive value to eliminate the need to biopsy an avascular solid nodule. Doppler imaging is useful in the evaluation of goiter, thyroid nodules, lymph nodes, and parathyroid glands.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Abbreviations

AACE:

American Association of Clinical Endocrinologists

AME:

Associazione Medici Endocrinologi

ATA:

American Thyroid Association

GD:

Graves’ disease

PI:

Pulsatility index

PPV:

Positive predictive value

PRF:

Pulse repetition frequency

PSV:

Peak systolic velocity

RAIU:

Radioactive iodine uptake

RI:

Resistive index

RR:

Relative risk

TBFA:

Thyroid blood flow area

References

  1. Cerbone G, Spiezia S, Colao A, Sarno D, et al. Power Doppler improves the diagnostic accuracy of color Doppler ultrasonography in cold thyroid nodules: follow-up results. Horm Res. 1999;52(1):19–24.

    CAS  PubMed  Google Scholar 

  2. Papini E, Guglielmi R, Bianchini A, Crescenzi A, et al. Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color Doppler features. J Clin Endocrinol Metab. 2002;87(5):1941–6.

    Article  CAS  PubMed  Google Scholar 

  3. Berni A, Tromba L, Falvo L, Marchesi M, et al. Malignant thyroid nodules: comparison between color Doppler diagnosis and histological examination of surgical samples. Chir Ital. 2002;54(5):643–7.

    PubMed  Google Scholar 

  4. Frates MC, Benson CB, Doubilet PM, Cibs ES, Marqusee E. Can color Doppler sonography aid in the prediction of malignancy of thyroid nodules? J Ultrasound Med. 2003;22:127–31.

    Article  PubMed  Google Scholar 

  5. Appetecchia M, Solivetti FM. The association of colour flow Doppler sonography and conventional ultrasonography improves the diagnosis of thyroid carcinoma. Horm Res. 2006;66(5):249–56.

    CAS  PubMed  Google Scholar 

  6. Moon HJ, Kwak JY, Kim MJ, et al. Can vascularity at power Doppler US help predict thyroid malignancy? Radiology. 2010;255(1):260–9.

    Article  PubMed  Google Scholar 

  7. Chammas MC, Gerhard R, de Oliveira IR, et al. Thyroid nodules: evaluation with power Doppler and duplex Doppler ultrasound. Otolaryngol Head Neck Surg. 2005;132(6):874–82.

    Article  PubMed  Google Scholar 

  8. Chammas MC. Why do we have so many controversies in thyroid nodule Doppler US? Radiology. 2011;259(1):304.

    Article  PubMed  Google Scholar 

  9. Rosario P, Silva A, Borges M, Calsolari MI. Doppler ultrasound of additional value to gray-scale ultrasound in differentiating malignant and benign thyroid nodules? Arch Endocrinol Metab. 2015;59(1):79–83.

    Article  PubMed  Google Scholar 

  10. Bakhshaee M, Davoudi Y, Mehrabi M, et al. Vascular pattern and spectral parameters of power Doppler ultrasound as predictors of malignancy risk in thyroid nodules. Laryngoscope. 2008;118(12):2182–6.

    Article  PubMed  Google Scholar 

  11. Algin O, Algin E, Gokalp G, et al. Role of duplex power Doppler ultrasound in differentiation between malignant and benign thyroid nodules. Korean J Radiol. 2010;11(6):594–602.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Ma JJ, Ding H, BH X, Xu C, Song LJ, Huang BJ, Wang WP. Diagnostic performances of various gray-scale, color Doppler, and contrast-enhanced ultrasonography findings in predicting malignant thyroid nodules. Thyroid. 2014;24(2):355–63.

    Article  PubMed  Google Scholar 

  13. Zhang B, Jiang Y, Liu J, et al. Utility of contrast-enhanced ultrasound for evaluation of thyroid nodules. Thyroid. 2010;20(1):51–7.

    Article  CAS  PubMed  Google Scholar 

  14. Cooper DS, Doherty GM, Haugen BR, et al. The American Thyroid Association Guidelines Task Force. Revised management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19:1167–214.

    Article  PubMed  Google Scholar 

  15. Gharib H, Papini E, Paschke R, Duick DS, et al. American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. Endocr Pract. 2010;16(Suppl 1):1–43.

    Article  PubMed  Google Scholar 

  16. Shin JH, Baek JH, Chung J, Ha EJ, et al. Ultrasonography diagnosis and imaging-based management of thyroid nodules: revised Korean Society of Thyroid Radiology consensus statement and recommendations. Korean J Radiol. 2016;17(3):370–95.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Haugen BR, Alexander EK, Bible KC, Doherty GM, et al. 2015 American Thyroid Association Management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1–133.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Gharib H, Papini E, Garber JR, Duick DS, et al. American Association of Clinical Endocrinologists, American College of Endocrinology, and Associazione Medici Endocrinologi medical guidelines for clinical practice for the diagnosis and management of thyroid nodules – 2016 update. Endocr Pract. 2016;22(5):622–39.

    PubMed  Google Scholar 

  19. Fukunari N, Nagahama M, Sugino K, et al. Clinical evaluation of color Doppler imaging for the differential diagnosis of thyroid follicular lesions. World J Surg. 2004;28(12):1261–5.

    Article  PubMed  Google Scholar 

  20. De Nicola H, Szejnfeld J, Logullo AF, et al. Flow pattern and vascular resistance index as predictors of malignancy risk in thyroid follicular neoplasms. J Ultrasound Med. 2005;24:897–904.

    Article  PubMed  Google Scholar 

  21. Levine RA. Value of Doppler ultrasonography in management of patients with follicular thyroid biopsies. Endocr Pract. 2006;12(3):270–4.

    Article  PubMed  Google Scholar 

  22. Iared W, Shigueoka DC, Cristófoli JC, et al. Use of color Doppler ultrasonography for the prediction of malignancy in follicular thyroid neoplasms: systematic review and meta-analysis. J Ultrasound Med. 2010;29(3):419–25.

    Article  PubMed  Google Scholar 

  23. Miyakawa M, Onoda N, Etoh M, et al. Diagnosis of thyroid follicular carcinoma by the vascular pattern and velocimetric parameters using high resolution pulsed and power Doppler ultrasonography. Endocr J. 2005;52(2):207–12.

    Article  PubMed  Google Scholar 

  24. Choi YJ, Yun JS, Kim DH. Clinical and ultrasound features of cytology diagnosed follicular neoplasm. Endocr J. 2009;56(3):383–9.

    Article  PubMed  Google Scholar 

  25. Trimboli P, Sorrenti S. Low value of color flow-Doppler in predicting malignancy of thyroid follicular neoplasms. Diagn Cytopathol. 2009;37(5):391–2.

    Article  PubMed  Google Scholar 

  26. Macedo TA, Chammas MC, Jorge PT, et al. Differentiation between the two types of amiodarone-associated thyrotoxicosis using duplex and amplitude Doppler sonography. Acta Radiol. 2007;48(4):412–21.

    Article  CAS  PubMed  Google Scholar 

  27. Bogazzi F, Bartelena L, Brogioni S, et al. Color flow Doppler sonography rapidly differentiates type I and type II amiodarone-induced thyrotoxicosis. Thyroid. 1997;7(4):541–5.

    Article  CAS  PubMed  Google Scholar 

  28. Eaton SE, Euinton HA, Newman CM, et al. Clinical experience of amiodarone-induced thyrotoxicosis over a 3-year period: role of colour-flow Doppler sonography. Clin Endocrinol. 2002;56(1):33–8.

    Article  CAS  Google Scholar 

  29. Wong R, Cheung W, Stockigt JR, Topliss DJ. Heterogeneity of amiodarone-induced thyrotoxicosis: evaluation of colour-flow Doppler sonography in predicting therapeutic response. Intern Med J. 2003;33(9-10):420–6.

    Article  CAS  PubMed  Google Scholar 

  30. Loy M, Perra E, Melis A, Cianchetti ME, Piga M, Serra A, Pinna G, Mariotti S. Color-flow Doppler sonography in the differential diagnosis and management of amiodarone-induced thyrotoxicosis. Acta Radiol. 2007;48(6):628–34.

    Article  CAS  PubMed  Google Scholar 

  31. Bogazzi F, Bartelena L, Martino E. Approach to the patient with amiodarone-induced thyrotoxicosis. J Clin Endocrinol Metab. 2010;95(6):2529–35.

    Article  CAS  PubMed  Google Scholar 

  32. Erdogan MF, Güleç S, Tutar E, Başkal N, Erdogan G. A stepwise approach to the treatment of amiodarone-induced thyrotoxicosis. Thyroid. 2003;13(2):205–9.

    Article  CAS  PubMed  Google Scholar 

  33. Ralls PW, Mayekowa DS, Lee KP, et al. Color-flow Doppler sonography in Graves disease: thyroid inferno. Am J Roentgenol. 1988;150:781–4.

    Article  CAS  Google Scholar 

  34. Bahn RS, Burch HB, Cooper DS, et al. Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid. 2011;21(6):593–646.

    Article  CAS  Google Scholar 

  35. Kahaly GJ, Bartalena L, Hegedus L. The American Thyroid Association/American Association of Clinical Endocrinologists guidelines for hyperthyroidism and other causes of thyrotoxicosis: a European perspective. Thyroid. 2011;21(6):585–91.

    Article  PubMed  Google Scholar 

  36. Ross DS, Burch HB, Cooper DS, Greenlee MC, et al. 2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid. 2016;26(10):1343–421.

    Article  PubMed  Google Scholar 

  37. Kurita S, Sakurai M, Kita Y, et al. Measurement of thyroid blood flow area is useful for diagnosing the cause of thyrotoxicosis. Thyroid. 2005;15(11):1249–52.

    Article  CAS  PubMed  Google Scholar 

  38. Uchida T, Takeno K, Goto M, Kanno R, et al. Superior thyroid artery mean peak systolic velocity for the diagnosis of thyrotoxicosis in Japanese patients. Endocr J. 2010;57(5):439–43.

    Article  PubMed  Google Scholar 

  39. Hari Kumar KVS, Pasupuleti V, Jayaraman M, et al. Role of thyroid Doppler in differential diagnosis of thyrotoxicosis. Endocr Pract. 2009;15(1):6–9.

    Article  CAS  PubMed  Google Scholar 

  40. Gaberšček S, Osolnik J, Zaletel K, Pirnat E, Hojker S. An advantageous role of spectral Doppler sonography in the evaluation of thyroid dysfunction during the postpartum period. J Ultrasound Med. 2016;35(7):1429–36.

    Article  PubMed  Google Scholar 

  41. Ota H, Amino N, Morita S, et al. Quantitative measurement of thyroid blood flow for differentiation of painless thyroiditis from Graves’ disease. Clin Endocrinol. 2007;67:41–5.

    Article  Google Scholar 

  42. Bogazzi F, Vitti P. Could improved ultrasound and power Doppler replace thyroidal radioiodine uptake to assess thyroid disease? Nat Clin Pract Endocrinol Metab. 2008;4(2):70–1.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Robert A. Levine MD, FACE, ECNU .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this chapter

Cite this chapter

Levine, R.A. (2018). Doppler Ultrasound. In: Duick, D., Levine, R., Lupo, M. (eds) Thyroid and Parathyroid Ultrasound and Ultrasound-Guided FNA . Springer, Cham. https://doi.org/10.1007/978-3-319-67238-0_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-67238-0_3

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-67237-3

  • Online ISBN: 978-3-319-67238-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics