Abstract
Cold spraying (CS) offers many advantages in front of the conventional thermal spraying processes and is becoming competitive in several industrial sectors. The biomedical industry is a quite well-established field, but still there are many challenges to solve where improvements in surface engineering can play a great role. The use of coatings in biomaterials has been fundamental on the improvement of mechanical as well as biological properties, thus, ameliorating human quality life. Studies about cold-sprayed coatings are emerging in orthopedics industry (internal fixation systems and prosthesis) as well as for antibacterial purposes (in body and touch external surfaces). These works are very new, and most deal with the improvement of biocompatibility and bioactivity of hard tissue replacement. Several combinations of substrate and coating materials are attempted, even trying to overcome any limitation on the spraying of ductile materials; biocompatible metallic materials, bioactive ceramics and polymers, and combinations have been successfully deposited by this method. Therefore, research on biocoatings is in constant development with the aim to produce implant surfaces that provide a balance between cell adhesion and low cytotoxicity, mechanical properties, and functionalization.
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References
Akedo J (2006) Aerosol deposition of ceramic thick films at room temperature: densification mechanism of ceramic layers. J Am Ceram Soc 89:1834–1839. https://doi.org/10.1111/j.1551-2916.2006.01030.x
Akedo J (2008) Room temperature impact consolidation (RTIC) of fine ceramic powder by aerosol deposition method and applications to microdevices. J Therm Spray Technol 17:181–198. https://doi.org/10.1007/s11666-008-9163-7
AL-Mangour B, Dallala R, Zhim F et al (2013a) Fatigue behavior of annealed cold-sprayed 316L stainless steel coating for biomedical applications. Mater Lett 91:352–355. https://doi.org/10.1016/j.matlet.2012.10.030
AL-Mangour B, Mongrain R, Irissou E, Yue S (2013b) Improving the strength and corrosion resistance of 316L stainless steel for biomedical applications using cold spray. Surf Coat Technol 216:297–307. https://doi.org/10.1016/j.surfcoat.2012.11.061
Kang AS, Singh G, Chawla V (2013) Some problems associated with thermal sprayed HA coatings: a review. Int J Surf Eng Mater Technol 3(1):10–14
Arifin A, Sulong AB, Muhamad N et al (2014) Material processing of hydroxyapatite and titanium alloy (HA/Ti) composite as implant materials using powder metallurgy: a review. Mater Des 55:165–175. https://doi.org/10.1016/j.matdes.2013.09.045
Bae G, Kang K, Kim J-J, Lee C (2010) Nanostructure formation and its effects on the mechanical properties of kinetic sprayed titanium coating. Mater Sci Eng A 527:6313–6319. https://doi.org/10.1016/j.msea.2010.06.037
Balla VK, Bodhak S, Bose S, Bandyopadhyay A (2010) Porous tantalum structures for bone implants: fabrication, mechanical and in vitro biological properties. Acta Biomater 6:3349–3359
Bauer S, Schmuki P, von der Mark K, Park J (2013) Engineering biocompatible implant surfaces. Prog Mater Sci 58:261–326. https://doi.org/10.1016/j.pmatsci.2012.09.001
Binder K, Gottschalk J, Kollenda M et al (2011) Influence of impact angle and gas temperature on mechanical properties of titanium cold spray deposits. J Therm Spray Technol 20:234–242. https://doi.org/10.1007/s11666-010-9557-1
Bobyn JD, Stackpool GJ, Hacing SA, Tanzer M, Krygier JJ (1999) Characteristics of bone ingrowth and interface mechanics of a new porous tantalum biomaterial. J Bone Joint Surg Br 81:907–914
Bosco R, Van Den Beucken J, Leeuwenburgh S, Jansen J (2012) Surface engineering for bone implants: a trend from passive to active surfaces. Coat 2:95–119. https://doi.org/10.3390/coatings2030095
Byrne GD, O’Neill L, Twomey B, Dowling DP (2013) Comparison between shot peening and abrasive blasting processes as deposition methods for hydroxyapatite coatings onto a titanium alloy. Surf Coat Technol 216:224–231. https://doi.org/10.1016/j.surfcoat.2012.11.048
Champagne V, Helfritch D (2013) A demonstration of the antimicrobial effectiveness of various copper surfaces. J Biol Eng 7:1–7
Chen MW, McCauley JW, Dandekar DP, Bourne NK (2006) Dynamic plasticity and failure of high-purity alumina under shock loading. Nat Mater 5:614–618
Chen Y, Bakshi SR, Agarwal A (2010) Correlation between nanoindentation and nanoscratch properties of carbon nanotube reinforced aluminum composite coatings. Surf Coat Technol 204:2709–2715. https://doi.org/10.1016/j.surfcoat.2010.02.024
Choudhuri A, Mohanty PS, Karthikeyan J (2009) Bio-ceramic composite coatings by cold spray technology. In: Proceedings of the international thermal spray conference, pp 391–396
Chun D-M, Ahn S-H (2011) Deposition mechanism of dry sprayed ceramic particles at room temperature using a nano-particle deposition system. Acta Mater 59:2693–2703. https://doi.org/10.1016/j.actamat.2011.01.007
Chun D-M, Choi J-O, Lee CS, Ahn S-H (2012) Effect of stand-off distance for cold gas spraying of fine ceramic particles (<5μm) under low vacuum and room temperature using nano-particle deposition system (NPDS). Surf Coat Technol 206:2125–2132. https://doi.org/10.1016/j.surfcoat.2011.09.043
Cinca N, Vilardell AM, Dosta S et al (2016) A new alternative for obtaining nanocrystalline bioactive coatings: study of hydroxyapatite deposition mechanisms by cold gas spraying. J Am Ceram Soc 99:1420–1428. https://doi.org/10.1111/jace.14076
Cizek J, Kovarik O, Siegl J et al (2013) Influence of plasma and cold spray deposited Ti layers on high-cycle fatigue properties of Ti6Al4V substrates. Surf Coat Technol 217:23–33. https://doi.org/10.1016/j.surfcoat.2012.11.067
Dikici B, Ozdemir I, Topuz M (2016) Cold spray deposition of SS316L powders on Al5052 substrates and their potential using for Biomedical applications. Int J Chem Mol Nucls Mater Metall Eng 10(4):483–487
El-Eskandrany MS, Al-Azmi A (2016) Potential applications of cold sprayed Cu50Ti20Ni30 metallic glassy alloy powders for antibacterial protective coating in medical and food sectors. J Mech Behav Biomed Mater 56:183–194. https://doi.org/10.1016/j.jmbbm.2015.11.030
Frattolin J, Barua R, Aydin H et al (2016) Development of a novel biodegradable metallic stent based on microgalvanic effect. Ann Biomed Eng 44:404–418. https://doi.org/10.1007/s10439-015-1458-5
Gardon M, Latorre A, Torrell M et al (2013) Cold gas spray titanium coatings onto a biocompatible polymer. Mater Lett 106:97–99. https://doi.org/10.1016/j.matlet.2013.04.115
Gardon M, Melero H, Garcia-Giralt N, Dosta S, Cano IG, Guilemany JM (2014) Enhancing the bioactivity of polymeric implants by means of cold gas spray coatings. J Biomed Mater Res Part B. 102(7):1537–1543
Gbureck U, Masten A, Probst J, Thull R (2003) Tribochemical structuring and coating of implant metal surfaces with titanium oxide and hydroxyapatite layers. Mater Sci Eng C 23:461–465. https://doi.org/10.1016/S0928-4931(02)00322-3
Gledhill H (2001) In vitro fatigue behaviour of vacuum plasma and detonation gun sprayed hydroxyapatite coatings. Biomaterials 22:1233–1240. https://doi.org/10.1016/S0142-9612(00)00273-8
Guilemany JM, Cinca N, Dosta S, Garcia I. (2014) Feasibility of cold gas spraying to produce high roughness high porous titanium coatings for metallic prosthesis. Thermal Spray Centre (CPT). Intellectual properties protection (iPP). Ref.1499 p 21
Guilemany JM, Dosta S, Cinca N, Fernández J, Garcia I. (2012) Feasibility of cold gas spraying to produce metal coatings onto activated polymeric substrates. Thermal Spray Centre (CPT). Intellectual properties protection (iPP). Ref.1240B p 10
Hahn B-D, Park D-S, Choi J-J et al (2009) Dense nanostructured hydroxyapatite coating on titanium by aerosol deposition. J Am Ceram Soc 92:683–687. https://doi.org/10.1111/j.1551-2916.2008.02876.x
Hailer NP, Lazarinis S, Mäkelä KT et al (2015) Hydroxyapatite coating does not improve uncemented stem survival after total hip arthroplasty!: an analysis of 116,069 THAs in the Nordic Arthroplasty Register Association (NARA) database. Acta Orthop 86:18–25. https://doi.org/10.3109/17453674.2014.957088
Hamweendo A., Popoola P. A. I., Botef I. (2014) Mathematical model for predicting process parameters in cold spray of porous Ti coatings. doi: 10.13140/2.1.2846.1123
Hasniyati M, Zuhailawati H, Sivakumar R et al (2015) Cold spray deposition of hydroxyapatite powder onto magnesium substrates for biomaterial applications. Surf Eng 31:867–874. https://doi.org/10.1179/1743294415Y.0000000068
Hasniyati MR, Zuhailawati H, Ramakrishnan S (2016) A statistical prediction of multiple responses using overlaid contour plot on hydroxyapatite coated magnesium via cold spray deposition. Procedia Chem 19:181–188. https://doi.org/10.1016/j.proche.2016.03.091
Heimann RB (2016) The challenge and promise of low-temperature bioceramic coatings: an editorial. Surf Coat Technol 301:1–5. https://doi.org/10.1016/j.surfcoat.2015.12.082
Ishikawa K, Miyamoto Y, Nagayama M, Asaoka K (1997) Blast coating method: new method of coating titanium surface with hydroxyapatite at room temperature. J Biomed Mater Res 38:129–134
Kang K, Bae G, Won J, Lee C (2012) Mechanical property enhancement of kinetic sprayed Al coatings reinforced by multi-walled carbon nanotubes. Acta Mater 60:5031–5039. https://doi.org/10.1016/j.actamat.2012.05.034
Ketola J (2014) Cold sprayed coatings in biomedicine, Master’s thesis, Tampere University of Technology
Kliemann J-O, Gutzmann H, Gärtner F et al (2011) Formation of cold-sprayed ceramic titanium dioxide layers on metal surfaces. J Therm Spray Technol 20:292–298. https://doi.org/10.1007/s11666-010-9563-3
Koivuluoto H (2010) Microstructural characteristics and corrosion properties of cold-sprayed coatings. Dissertation, Tampere University of Technology
Laonapakul T, Otsuka Y, Nimkerdphol AR, Mutoh Y (2012a) Acoustic emission and fatigue damage induced in plasma-sprayed hydroxyapatite coating layers. J Mech Behav Biomed Mater 8:123–133. https://doi.org/10.1016/j.jmbbm.2011.11.011
Laonapakul T, Rakngarm Nimkerdphol A, Otsuka Y, Mutoh Y (2012b) Failure behavior of plasma-sprayed HAp coating on commercially pure titanium substrate in simulated body fluid (SBF) under bending load. J Mech Behav Biomed Mater 15:153–166. https://doi.org/10.1016/j.jmbbm.2012.05.017
Lee JH, Jang HL, Lee KM, Baek H-R, Jin K, Hong KS et al (2013) In vitro and in vivo evaluation of the bioactivity of hydroxyapatite- coated polyetheretherketone biocomposites created by cold spray technology. Acta Biomater 9:6177–6187
Li C-J, Li W-Y (2003) Deposition characteristics of titanium coating in cold spraying. Surf Coat Technol 167:278–283. https://doi.org/10.1016/S0257-8972(02)00919-2
Li W-Y, Zhang C, Guo X et al (2007) Ti and Ti-6Al-4V coatings by cold spraying and microstructure modification by heat treatment. Adv Eng Mater 9:418–423. https://doi.org/10.1002/adem.200700022j
Liu X, Chu PK, Ding C (2010) Surface nano-functionalization of biomaterials. Mater Sci Eng R Rep 70:275–302. https://doi.org/10.1016/j.mser.2010.06.013
Liu Y, Dang Z, Wang Y et al (2014a) Hydroxyapatite/graphene-nanosheet composite coatings deposited by vacuum cold spraying for biomedical applications: inherited nanostructures and enhanced properties. Carbon 67:250–259. https://doi.org/10.1016/j.carbon.2013.09.088
Liu Y, Huang J, Li H (2014b) Nanostructural characteristics of vacuum cold-sprayed hydroxyapatite/graphene-nanosheet coatings for biomedical applications. J Therm Spray Technol 23:1149–1156. https://doi.org/10.1007/s11666-014-0069-2
Lozier A, Poopola OO, Mason JJ, Forstein M (2009) Bone fracture fixation system, US Papent no US 2009/0198286 A1
Melero H, Fernández J, Dosta S, Guilemany JM (2011) Characterization of novel bioactive hydroxyapatite-TiO2 coatings obtained by high velocity oxy-fuel. In: Proceedings of the thermal spray conference, Hamburg, Germany
Moore B, Asadi E, Lewis G (2017) Deposition methods for microstructured and nanostructured coatings on metallic bone implants: a review. Adv Mater Sci Eng 2017:1–9. https://doi.org/10.1155/2017/5812907
Mukhopadhyay A, Joshi K, Dey A, Chakraborty R, Rav A, Biswas S et al (2010) Shock deformation of coarse grain alumina above Hugoniot elastic limit. J Mater Sci 45:3635–3651. https://doi.org/10.1007/s10853-010-4409-4
Noh JH, Kim DW, An JS, Chang HR, Kim DH, Hong KS, Chin DK (2012) Method for modifying the surface area of a bioinert material. US Patent 0009341 A1, 12 Jan 2012
Noorakma ACW, Zuhailawati H, Aishvarya V, Dhindaw BK (2013) Hydroxyapatite-coated magnesium-based biodegradable alloy: cold spray deposition and simulated body fluid studies. J Mater Eng Perform 22:2997–3004. https://doi.org/10.1007/s11665-013-0589-9
O’Hare P, Meenan BJ, Burke GA et al (2010) Biological responses to hydroxyapatite surfaces deposited via a co-incident microblasting technique. Biomaterials 31:515–522. https://doi.org/10.1016/j.biomaterials.2009.09.067
O’Neill L, O’Sullivan C, O’Hare P et al (2009) Deposition of substituted apatites onto titanium surfaces using a novel blasting process. Surf Coat Technol 204:484–488. https://doi.org/10.1016/j.surfcoat.2009.08.014
O’Sullivan C, O’Hare P, O’Leary ND et al (2010) Deposition of substituted apatites with anticolonizing properties onto titanium surfaces using a novel blasting process. J Biomed Mater Res B Appl Biomater 95B:141–149. https://doi.org/10.1002/jbm.b.31694
Park D-S, Kim I-S, Kim H, et al (2010) Improved biocompatibility of hydroxyapatite thin film prepared by aerosol deposition. J Biomed Mater Res B Appl Biomater n/a-n/a doi: https://doi.org/10.1002/jbm.b.31658
Price TS, Shipway PH, McCartney DG (2006) Effect of cold spray deposition of a titanium coating on fatigue behavior of a titanium alloy. J Therm Spray Technol 15:507–512. https://doi.org/10.1361/105996306X147108
Qiu D, Zhang M, Grøndahl L (2013) A novel composite porous coating approach for bioactive titanium-based orthopedic implants. J Biomed Mater Res 101A:862–872. https://doi.org/10.1002/jbm.a.34372
Ratner BD, Hoffman AS, Schoen FJ, Lemons JE (2013) Introduction – biomaterials science: an evolving, multidisciplinary endeavor. In: Ratner BD, Hoffman AS, Schoen FJ, Lemons JE (eds) Biomaterials science, 3rd edn. Academic Press, San Diego
Salim NT, Yamada M, Nakano H, Fukumoto M (2011) The synthesis of titanium dioxide (TiO2) powder for cold spray process. IOP Conf Series Mater Sci Eng 18:32019. https://doi.org/10.1088/1757-899X/18/3/032019
Sanpo N, Ang SM, Cheang P, Khor KA (2009a) Antibacterial property of cold sprayed chitosan-Cu/Al coating. J Therm Spray Technol 18:600–608. https://doi.org/10.1007/s11666-009-9391-5
Sanpo N, Hailan C, Loke K, Keng KP, Cheang P, Berndt CC, et al. (2010) Biocompatibility and antibacterial property of cold sprayed ZnO/titanium composite coating. In: Mendez-Vilas A (ed). Science and technology against microbial pathogens. Research, development and evaluation. In: proceedings of the international conference on antimicrobial research, World Scientific pp 140–44
Sanpo N, Saraswati, Lu TM, Cheang P (2008) Anti-bacterial property of cold sprayed ZnO-Al coating. In: Proceedings of the 2008 international conference on biomedical engineering and informatics, Sanya, Hainan, China
Sanpo N, Tan M, Cheang P, Khor KA (2009b) Antibacterial property of cold-sprayed HA-Ag/PEEK coating. J Therm Spray Technol 18:10–15
Saphronov V, Shishkovsky I (2015) Laser annealing for gas-dynamical spraying of HA coating upon a titanium surface. Crystals 5:447–457. https://doi.org/10.3390/cryst5040447
Shtansky DV, Batenina IV, Yadroitsev IA et al (2012) A new combined approach to metal-ceramic implants with controllable surface topography, chemistry, blind porosity, and wettability. Surf Coat Technol 208:14–23. https://doi.org/10.1016/j.surfcoat.2012.07.008
Shukla V, Elliott G, Kear B, McCandlish L (2001) Hyperkinetic deposition of nanopowders by supersonic rectangular jet impingement. Script Mater 44:2179–2182
Singh RP (2011) Numerical evaluation, optimization and mathematical validation of cold spraying of hydroxyapatite using taguchi approach. Int J Eng Sci Technol 3:7006–7015
Singh RP, Batra U (2013) Effect of cold spraying parameters and their interaction an hydroxyapatite deposition. J Appl Fluid Mech 6(4):555–561
Sun J, Han Y, Cui K (2008) Innovative fabrication of porous titanium coating on titanium by cold spraying and vacuum sintering. Mater Lett 62:3623–3625. https://doi.org/10.1016/j.matlet.2008.04.011
Sun L, Berndt CC, Gross KA, Kucuk A (2001) Material fundamentals and clinical performance of plasma-sprayed hydroxyapatite coatings: a review. J Biomed Mater Res 58:570–592
Taha M, Chai F, Blanchemain N et al (2013) Validating the poly-cyclodextrins based local drug delivery system on plasma-sprayed hydroxyapatite coated orthopedic implant with toluidine blue O. Mater Sci Eng C 33:2639–2647. https://doi.org/10.1016/j.msec.2013.02.022
Tamai K, Kawate K, Kawahara I, Takakura Y, Sakaki K (2009) Inorganic antimicrobial coating for titanium alloy and its effect on bacteria. J Orthop Sci 14:204–209
Trentin A, Vezzu S, Rech S, Gulizia S and Jahedi M (2011) Biocompatibility of titanium coatings deposites on CoCr by cold spray. In: Proceedings of the international thermal spray conference, Hamburg, Germany
Van Steenkiste T, Gorkiewicz DW (2004) Analysis of tantalum coatings produced by the kinetic spray process. J Therm Spray Technol 13:265–273. https://doi.org/10.1361/10599630419418
Vilardell AM, Cinca N, Cano IG, et al (2016) Dense nanostructured calcium phosphate coating on titanium by cold spray. J Eur Ceram Soc doi: https://doi.org/10.1016/j.jeurceramsoc.2016.11.040
Vo P, Irissou E, Legoux J-G, Yue S (2013) Mechanical and microstructural characterization of cold-sprayed Ti-6Al-4V after heat treatment. J Therm Spray Technol 22:954–964. https://doi.org/10.1007/s11666-013-9945-4
Vucko MJ, King PC, Poole AJ et al (2012) Cold spray metal embedment: an innovative antifouling technology. Biofouling 28:239–248. https://doi.org/10.1080/08927014.2012.670849
Wang J, DiPietro J, Bostrom M et al (2014) Clinical and radiographic outcomes with a hydroxyapatite and porous coated cup design. Adv Orthop Surg 2014:1–5. https://doi.org/10.1155/2014/302969
Wong W., Rezaeian A., Yue S., Wong W., Rezaeian A., Yue S. (2009) Effects of gas temperature, gas pressure, and particle characteristics on cold sprayed pure titanium coatings, International Thermal Spray Conference (ITSC) 2009 American Society for Metals doi: https://doi.org/10.1361/cp2009itsc0231
Zhang L, Zhang WT (2011) Numerical investigation on particle velocity in cold spraying of hydroxyapatite coating. Adv Mater Res 18:717–722
Zhang S (2011) Biological and Biomedical coatings handbook, vol 2. Taylor & Francis, Boca Raton
Zhao L, Chu PK, Zhang Y, Wu Z (2009) Antibacterial coatings on titanium implants. J Biomedl Mater Res Part B 91B:470–480
Zhou X (2012) Hydroxyapatite/titanium composite coating for biomedical applications. Dissertation, University of Michigan
Zhou X, Mohanty P (2012) Electrochemical behavior of cold sprayed hydroxyapatite/titanium composite in hanks’ solution. Electrochim Acta 65:134–140
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Dosta, S., Cinca, N., Vilardell, A.M., Cano, I.G., Guilemany, J.M. (2018). Cold Spray Coatings for Biomedical Applications. In: Cavaliere, P. (eds) Cold-Spray Coatings. Springer, Cham. https://doi.org/10.1007/978-3-319-67183-3_19
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